1st Edition

Advanced Pharmaceutics Physicochemical Principles

By Cherng-ju Kim Copyright 2004
512 Pages 270 B/W Illustrations
by CRC Press

512 Pages
by CRC Press

Discussing a comprehensive range of topics, Advanced Pharmaceutics: Physicochemical Principles reviews all aspects of physical pharmacy. The book explains the basic, mechanistic, and quantitative interpretation skills needed to solve physical pharmacy related problems. The author supplies a strong fundamental background and extensively covers thermodynamics, ionic equilibria, solutions and... Read more
THERMODYNAMICS
Ideal Gases
Real Gases
Thermodynamics
Free Energy

IONIC EQUILIBRIUM
Strong Acids and Bases
Monoprotic Weak Acids and Weak Bases
Polyprotic Weak Acids and Weak Bases
Sparingly Soluble Salts

SOLUTIONS AND DISTRIBUTION
Solutions of Solids and Non-volatile Liquids in Liquids
Solutions of Volatile Liquids in Liquids
Solutions of Gases in Liquids (Henry's Law)
Colligative Properties
Distribution Law (Partition Coefficient)

SURFACE CHEMISTRY AND COLLOIDS
Adsorption from Solutions
Liquid-Liquid Systems (Emulsions)
Solid-Liquid Systems (Suspensions)

KINETICS
Pathways of Drug Degradation
Single and Multiple Reactions, Elementary Reactions, Molecularity, and Order of Reactions
Irreversible Reactions
Determination of the Order of Reaction and Its Rate Constant
Other Irreversible Reactions
Reversible Reactions
Reversible and Series Reactions (Eigenvalue Method)
Use of Laplace Transform for Differential Rate Equations
Enzyme-Substrate Reactions
Acid-Base Catalyzed Degradation Kinetics
Oxidation (Free Radical Reaction)
Degradation Kinetics in Inclusion Complexes, Micelles, and Liposomes
Temperature Effects on Reaction Rate Constants

DIFFUSION
Diffusion
Diffusion Through a Membrane
Diffusion in a Monolithic Matrix
Diffusion in a Membrane-Matrix System
Diffusion During the Swelling of Matrix
Diffusion in a Matrix Erosion/Degradation
Diffusion in a Matrix Swelling/Erosion
Diffusion with Chemical Reaction in a Membrane
Surface Area and Concentration Gradient Systems
Osmotically Controlled Systems

POLYMER SCIENCE
Classification of Polymers
Molecular Weight and Molecular Weight Distribution of Polymers
Characterization of Polymers
Polymer Synthesis
Natural Polymers and Their Modification
INDEX

Biography

Cherng-ju Kim

"The book contains 22 chapters and covers a very wide range of topics. With a few exceptions, these contributions are from leaders in the field of drug delivery. The ideas and results presented are all extremely creative and interesting. This reviewer would recommend this book as it presents a broad selection of some very interesting directions that polymer drug delivery will be taking in the near future."
-Lisa Brannon-Peppas, PhD, The Department of Biomedical Engineering, The University of Texas at Austin