1st Edition

An Introduction to Biomedical Optics

By Robert Splinter, Brett A. Hooper Copyright 2007
    624 Pages 30 B/W Illustrations
    by CRC Press

    Many universities now offer a course in biomedical optics, but lack a textbook specifically addressing the topic. Intended to fill this gap, An Introduction to Biomedical Optics is the first comprehensive, introductory text describing both diagnostic and therapeutic optical methods in medicine. It provides the fundamental background needed for graduate students in biomedical and electrical engineering, physics, biology, and medicine to learn about several biomedical optics issues.

    The textbook is divided into three main sections: general optics theory, therapeutic applications of light, and diagnostic optical methods. Each chapter has different levels of detail to build students' knowledge from one level to the next. The first section covers the history of optics theory and the basic science behind light-tissue interactions. It also introduces the relevant approaches and approximations used to describe light propagation in turbid biological media. In the second section, the authors look more closely at light-tissue interactions and their applications in different medical areas, such as wound healing and tissue welding. The final section examines the various diagnostic methods that are employed using optical techniques. Throughout the text, the authors employ numerical examples of clinical and research requirements.

    Fulfilling the need for a concise biomedical optics textbook, An Introduction to Biomedical Optics addresses the theory and applications of this growing field.

    GENERAL BIOMEDICAL OPTICS THEORY
    Introduction to the Use of Light for Diagnostic and Therapeutic Modalities
    What Is Biomedical Optics?
    Biomedical Optics Timeline
    Elementary Optical Discoveries
    Historical Events in Therapeutic and Diagnostic Use of Light
    Light Sources
    Current State of the Art
    Summary
    Additional Reading
    Problems

    Review of Optical Principles: Fundamental Electromagnetic Theory and Description of Light Sources
    Definitions in Optics
    Kirchhoff's Laws of Radiation
    Electromagnetic Wave Theory
    Light Sources
    Applications of Various Lasers
    Summary
    Additional Reading
    Problems

    Review of Optical Principles: Classical Optics
    Geometrical Optics
    Other Optical Principles
    Quantum Physics
    Gaussian Optics
    Summary
    Additional Reading
    Problems

    Review of Optical Interaction Properties
    Absorption and Scattering
    Summary
    Additional Reading
    Problems

    Light-Tissue Interaction Variables
    Laser Variables
    Tissue Variables
    Light Transportation Theory
    Light Propagation under Dominant Absorption
    Summary
    Nomenclature
    Additional Reading
    Problems

    Light-Tissue Interaction Theory
    Approximations of the Equation of Radiative Transport
    Summary
    Additional Reading
    Problems

    Numerical and Deterministic Methods in Light-Tissue Interaction Theory
    Numerical Method to Solve the Equation of Radiative Transport
    Measurement of Optical Parameters
    Temperature Effects of Light-Tissue Interaction
    Summary
    Additional Reading
    Problems

    Light-Tissue Interaction Mechanisms and Applications: Photophysical
    Range of Photophysical Mechanisms
    Photoablation
    Photoacoustics
    Birefringence Effects
    Polarization Effects
    Optical Activity
    Evanescent Wave Interaction in Biomedical Optics
    Phase Interference Effects
    Spectroscopy
    Endoscopy
    Summary
    Additional Reading
    Problems

    Light-Tissue Interaction Mechanisms and Applications: Photochemical
    Basic Photochemical Principles
    Photochemical Effects
    Summary
    Additional Reading
    Problems

    Light-Tissue Interaction Mechanisms and Applications: Photobiological
    Photobiological Biostimulation
    Photobiological Effects
    Excitation of Chromophores
    Optic Nerve-Cell Depolarization under the Influence of Light (Vision)
    Summary
    Additional Reading
    Problems

    THERAPEUTIC APPLICATIONS OF LIGHT
    Therapeutic Applications of Light: Photophysical
    Delivery Considerations
    Pulsed Laser Use in Cardiology
    Dentistry and Oral Surgery
    Ophthalmology
    Optical Tweezers
    Summary
    Additional Reading
    Problems

    Therapeutic Applications of Light: Photochemical
    Vascular Welding
    Cosmetic Surgery
    Oncology
    Summary
    Additional Reading
    Problems

    Therapeutic Applications of Light: Photobiological
    Cardiology & Cardiovascular Surgery
    Soft tissue Treatment
    Dermatology
    Fetal Surgery
    Gastroenterology
    General Surgery
    Gynecology
    Neurosurgery
    Ophthalmology
    Pulmonology & Otorhinolaryngology
    Otolaryngology, Ear-Nose, and Throat (ENT) and Maxillofacial Surgery
    Podiatry
    Urology
    Summary
    Additional Reading
    Problems

    DIAGNOSTIC APPLICATIONS OF LIGHT
    Diagnostic Methods Using Light: Photophysical
    Optical Microscopy
    Various Microscopic Techniques
    Near-Field Scanning Optical Microscope
    Spectroscopy
    Holographic Imaging
    Polarization Imaging
    Transillumination Imaging
    Optical Coherence Tomography
    Ballistic Photon Imaging
    Reflectometry
    Evanescent Wave Imaging Applications
    Medical Thermography
    Photoacoustic Imaging
    Tera Hertz Imaging
    Summary
    Additional Reading
    Problems

    Diagnostic Methods Using Light: Photochemical
    Fluorescence Imaging
    Ratio Fluorescence Microscopy
    Raman Spectroscopy with NSOM Employed
    Optical "Tongue"
    Summary
    Additional Reading
    Problems

    Diagnostic Methods Using Light: Photobiological
    Immuno Staining ("Functional Imaging")
    Immunofluorescence
    Diagnostic Applications of Spectroscopy
    Fiberoptic Sensors
    Optical Coherence Tomography in Dentistry
    Optical Biopsy
    Determination of Blood Oxygenation
    Electroluminescent Electro-Physiologic Mapping
    Quantum Dots as Biological Fluorescent Markers
    Compilation of the Optical Requirements for Wavelength Selection Based on the Desired Effects
    Summary
    Additional Reading
    Problems

    Biography

    Robert Splinter, Brett A. Hooper

    "An outstanding feature of the book is its carefully designed structure which makes it abundantly clear where required material is located . . . one should commend the high standard of production of the book; it is well laid out . . . Overall it is considered that acquisition of this book will be an excellent investment for anyone who wishes to gain an appreciation of the principles and applications of biomedical optics."

    – Professor K. A. Shore, University of Wales, in Contemporary Physics, November 2007