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Cell Culture Technology for Pharmaceutical and Cell-Based Therapies

Edited by Sadettin Ozturk, Wei-Shou Hu

Contributors: Sadettin Ozturk, Amy Y. Shen, A. Burgener, Francesc Godia, Sarah W. Harcum, Christel Fenge, Ninging Ma, Mark Riley, An-Ping Zeng, Liangzhi Xie, Dhinakar S. Kompala, Thomas Seewoester, Ron Bates, Chandra M. Dwivedi, Kim Nelson, Alain R. Bernard, Laura A. Palomares, E.S. Tzanakakis, A. Mantalaris, Jing- xiu Bi, Jordi Joan Cairo, Jeffrey J. Chalmers, M. E. M. Cromwell, Sandino Estrada-Mondaca, Mike Mollet, Octavio T. Ramirez, C. M. Verfaillie, J. H. D. Wu, Weichang Zhou, Jana Van de Goor, Lisa Zheng, Arthur E. Reyes, Lynne A. Krummen, M. Butler

Published August 30th 2005 by CRC Press – 776 pages

Series: Biotechnology and Bioprocessing

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Description

Edited by two of the most distinguished pioneers in genetic manipulation and bioprocess technology, this bestselling reference presents a comprehensive overview of current cell culture technology used in the pharmaceutical industry. Contributions from several leading researchers showcase the importance of gene discovery and genomic technology development in the production of biotechnology products, tissue engineering, and cell-based therapies. Offering detailed guidance, they cover the steps leading up to the creation of viable therapies including host cell selection, cloning and gene amplification, bioreactor design and operation, protein purification, optimization, scale-up, and facility design.

Reviews

"…The editors have brought together an outstanding group of experts from both private industry and academia….recommend[ed]."

-Doody's Reviews

Contents

Preface. Cell Culture Technology: An Overview. Recombinant DNA Technology and Cell Line Development. Medium Development. Cell Metabolism. Protein Glycosylation. Cell Culture Bioreactors. Aeration, Mixing and Hydrodynamics in Bioreactors. Instrumentation and Process Control. Cell Culture Kinetics and Modeling. Fed-Batch Cultivation Of Mammalian Cells For Production Of Recombinant Proteins. Optimization of High Density Perfusion Bioreactors. Cell Separation And Product Capture. Downstream Processing. Formulation, Finishing, and Packaging. Validation Of Cell Culture Based Processes & Qualification Of Associated Equipment And Facility. Facility Design. Transient Expression of Proteins. Large-Scale Propagation of Insect Cells. Advances In Adult Stem Cell Culture. Ex Vivo Culture Of Hematopoietic And Mesenchymal Stem Cells For Tissue Engineering And Cell-Based Therapies.

Name: Cell Culture Technology for Pharmaceutical and Cell-Based Therapies (Hardback) – CRC Press 
Description: Edited by Sadettin Ozturk, Wei-Shou HuContributors: Sadettin Ozturk, Amy Y. Shen, A. Burgener, Francesc Godia, Sarah W. Harcum, Christel Fenge, Ninging Ma, Mark Riley, An-Ping Zeng, Liangzhi Xie, Dhinakar S. Kompala, Thomas Seewoester, Ron Bates, Chandra M. Dwivedi, Kim Nelson, Alain R. Bernard, Laura A. Palomares, E.S. Tzanakakis, A. Mantalaris, Jing- xiu Bi, Jordi Joan Cairo, Jeffrey J. Chalmers, M. E. M. Cromwell, Sandino Estrada-Mondaca, Mike Mollet, Octavio T. Ramirez, C. M. Verfaillie, J. H. D. Wu, Weichang Zhou, Jana Van de Goor, Lisa Zheng, Arthur E. Reyes, Lynne A. Krummen, M. Butler. Edited by two of the most distinguished pioneers in genetic manipulation and bioprocess technology, this bestselling reference presents a comprehensive overview of current cell culture technology used in the pharmaceutical industry. Contributions from...
Categories: Biotechnology, Biopharmaceutics, Biochemistry