1st Edition

Cell Death The Role of PARP

Edited By Csaba Szabo Copyright 2000
352 Pages
by CRC Press

352 Pages
by CRC Press

Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in mammalian cells, a novel role was proposed for this enzyme, mediating a suicidal mechanism triggered by... Read more
Preface
Cell Death by Energy Depletion: Discovery and Early Developments, Nathan Berger
Oxidative Stress and PARS Activation, James Kirkland
Nitrosative Stress and PARS Acitvation, J. Zhang, Solomon Snyder, and Guilford Pharmaceuticals, Inc.
PARS in Regulating Cell Necrosis and Apoptosis, Laszlo Virag and Csaba Szabo
PARS in Mediating Neuronal Injury in Stroke and Neurotrauma, Matthias Endres and Michael Moschowitz
PARS in Mediating Chronic Neurodegeneration, Valina Dawson and Ted Dawson
PARS Activation and Myocardial Reperfusion Injury, Basilia Zingarelli and Christoph Thiemermann
Role of PARS Activation in the Pathophysiology of Endotoxic and Hemorrhagic Shock, Csaba Szabo
Role of PARS Activation in Diabetes, Hubert Kolb
PARS Activation and Arthritas, H. Kroger
PARS Activation and Inflammatory Bowel Disease, Andrew Salzman
PARS in Regulating Macrophage Activation and Gene Expression, J. Draper
Pharmacological Inhibitors of PARS, E. Kun

Biography

Csaba Szabo