240 Pages
52 B/W Illustrations
by
CRC Press
240 Pages
by
CRC Press
Also available as eBook on:
The ballooning body of research devoted to hyaluronan (HA) reflects its enormous potential for various medical applications. There have been many successes of varying degrees in the development of medical products based on HA, but also some setbacks. While there is obviously ample information available on the chemistry and various properties of this macromolecule, Practical Aspects of Hyaluronan... Read more
OVERVIEW
Discovery
Primary Structure
Molecular Formula
Member of Glycosaminoglycans
HA Structures of Higher Orders
Viscosity, Molecular Weight, and Structures
Source and Isolation
Distribution and Catabolism
Influence on Cell Behavior
Chemical Modification
HA-Based Medical Products
Ever-Growing Interest
References
CHEMISTRY
Chemistry in Structural Investigation
Chromogenic Reactions
Chemistry of HA Degradation
Chemistry in Isotopic Labeling
Synthesis of Fluorescent HA
Biotinylated HA
HA Derivatives with Various Side Chains
HA-Drug Conjugation
Chemical Crosslinking of HA
Preparation of Oligosaccharides
Sulfation of HA
Summary of Methods of Chemical Modification
References
RHEOLOGICAL PROPERTIES OF HYALURONAN AS RELATED TO ITS STRUCTURE, SIZE, AND CONCENTRATION
Some Basic Concepts of Intrinsic Viscosity
Hydrodynamic Volume and Molecular Structures
Absolute Viscosity Measured at Steady State
Viscoelasticity
References
STANDARDS, TESTS, AND ANALYTICAL METHODS
Standards and Specifications
Analyses of HA Structure, Size, and Quantity
Natural Polymeric Impurities
Other Bioassays
Lipoteichoic Acid
Chemical Methods of Radiolabeling
References
SAFETY OF HYALURONAN-BASED MEDICAL PRODUCTS IN THEIR INDICATED APPLICATIONS
General Safety Considerations
Safety Information from Specific Human Use
References
CLINICAL PERFORMANCE, MECHANISM OF ACTION, AND PRODUCT CHARACTERISTICS
Ophthalmic Surgeries
Injections for Osteoarthritic Knees
Adhesion Prevention and Wound Healing
Tissue Augmentation
Dental and Bone Application
References
INDEX
Discovery
Primary Structure
Molecular Formula
Member of Glycosaminoglycans
HA Structures of Higher Orders
Viscosity, Molecular Weight, and Structures
Source and Isolation
Distribution and Catabolism
Influence on Cell Behavior
Chemical Modification
HA-Based Medical Products
Ever-Growing Interest
References
CHEMISTRY
Chemistry in Structural Investigation
Chromogenic Reactions
Chemistry of HA Degradation
Chemistry in Isotopic Labeling
Synthesis of Fluorescent HA
Biotinylated HA
HA Derivatives with Various Side Chains
HA-Drug Conjugation
Chemical Crosslinking of HA
Preparation of Oligosaccharides
Sulfation of HA
Summary of Methods of Chemical Modification
References
RHEOLOGICAL PROPERTIES OF HYALURONAN AS RELATED TO ITS STRUCTURE, SIZE, AND CONCENTRATION
Some Basic Concepts of Intrinsic Viscosity
Hydrodynamic Volume and Molecular Structures
Absolute Viscosity Measured at Steady State
Viscoelasticity
References
STANDARDS, TESTS, AND ANALYTICAL METHODS
Standards and Specifications
Analyses of HA Structure, Size, and Quantity
Natural Polymeric Impurities
Other Bioassays
Lipoteichoic Acid
Chemical Methods of Radiolabeling
References
SAFETY OF HYALURONAN-BASED MEDICAL PRODUCTS IN THEIR INDICATED APPLICATIONS
General Safety Considerations
Safety Information from Specific Human Use
References
CLINICAL PERFORMANCE, MECHANISM OF ACTION, AND PRODUCT CHARACTERISTICS
Ophthalmic Surgeries
Injections for Osteoarthritic Knees
Adhesion Prevention and Wound Healing
Tissue Augmentation
Dental and Bone Application
References
INDEX
Biography
J.W. Kuo
