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Cancer Epigenetics

Edited by Trygve Tollefsbol

Published September 19th 2008 by CRC Press – 472 pages

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Description

During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy.

Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy.

Discusses the Latest Advances in the Role of Epigenetics in Tumor Initiation, Progression, and Metastasis

With stand-alone chapters written by research pioneers in the field, this definitive resource covers—

  • DNA methylation and cancer
  • Histone modifications in cancer
  • Emerging areas of cancer epigenetics
  • Epigenetics in the diagnosis, prognosis, and therapy of cancer
  • Future directions in epigenetic cancer research

    • Bringing together different topics into a single compilation, this text is a prime resource for those with interests ranging from the basic mechanisms of tumor biology to cancer therapy. It also serves as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer. This seminal work answers the call for a thorough and authoritative reference that covers the critical and contemporary aspects of this revolutionary field.

    Reviews

    "This book is an indispensable reference for those with interests from the basic mechanisms of tumor biology to cancer therapy. Serving as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer, this seminal work answers the call for a thorough and authoritative reference that covers the critical and contemporary aspects of this revolutionary field."

    – In Anticancer Research, 2009, Vol. 29

    Contents

    The Role of Epigenetics in Cancer, T.O. Tollefsbol

    Section 1:  DNA Methylation and Cancer

    DNA Hypomethylation in Cancer, P.L. Molloy

    DNA Hypermethylation in Oncogenesis, J.T. DeAngelis, J.B. Berletch, L.G. Andrews, and T.O. Tollefsbol

    Imprinting Alterations in Tumorigenesis, J. Bernier-Latmani and P. Shaw

    Proteins that Modulate DNA Methylation Aberrations in Cancer, S. L. Walthall, S.M.O. Phipps, L.G. Andrews, and T. O. Tollefsbol

    The Role of DNA Methylation in Cancer Progression, S.-W. Choi and S. Friso

    Section 2:  Histone Modifications in Cancer

    Alterations in Histone Acetylation in Tumorigenesis, S.N. Saldanha and T.O. Tollefsbol

    Histone Methylation and the Initiation of Cancer, S. Huang

    The Role of Sirtuins in Aging and Tumorigenesis, X. Zhang, T. I. Hseih, S. V. Nicosia, and W. Bai

    Proteins that Alter Histone Modifications in Cancer, A. Ao and J. Lu

    Dietary and Environmental Influences on Histone Modifications in Cancer, S.N. Saldanha, V. Nandakumar, A. Elgavish, and T. O. Tollefsbol

    Section 3:  Other Epigenetic Aspects of Cancer

    Noncoding RNAs in Cancer, M. Szymanski and J. Barciszewski

    Cancer-linked DNA Hyper- and Hypomethylation: Chromosome Positional Effects, M. Ehrlich

    Chromatin Remodeling and Cancer, S. Pennings and R.R. Meehan

    Poly-ADP-ribosylation in Cancer, R.N. Sharan

    Polycomb Group Proteins in Tumorigenesis, H.E.C. Niessen and J.W. Voncken

    Cancer and Aging: The Epigenetic Connection, C.A. Cooney

    Section 4:  Epigenetics in the Diagnosis, Prognosis and Therapy of Cancer

    DNA Methylation in Tumor Diagnosis, K. Ramachandran, E. Gordian and R. Singal

    DNA Methylation Profiles as Prognostic Markers for Cancer, S. Thiagalingam and P. Papageorgis

    Diagnosing Cancer Using Histone Modification Analysis, M. Verma and D. Kumar

    Histone Modifications in Cancer Biology and Prognosis, M.A. McBrian, D. B. Seligson, and S. K. Kurdistani

    Histone Deacetylase Inhibitors in Cancer Therapy, A.M. Sargeant, S.K. Kulp, Y.-S. Lu, A.-L. Cheng, and C.-S. Chen

    Methylation Changes in Neoplasia: Diagnostic and Therapeutic Implications, E. Hatzimichael, J. Stebbing, and T. Crook

    Clinical Trials and Approved Drugs for Epigenetic Cancer Therapy, D.M.E.I. Hellebrekers and M. van Engeland

    Section 5:  Future Directions

    Future Directions in Epigenetic Cancer Research , J. Peedicayil

    Name: Cancer Epigenetics (Hardback) – CRC Press 
    Description: Edited by Trygve Tollefsbol. During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging...
    Categories: Molecular Biology, Genetics, Oncology