1st Edition

Molecular, Cellular, and Tissue Engineering

1892 Pages 461 B/W Illustrations
by CRC Press

1892 Pages 461 B/W Illustrations
by CRC Press

Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition , sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering. Molecular, Cellular, and Tissue Engineering , the fourth volume of the handbook, presents material... Read more

MOLECULAR BIOLOGY

Historical Perspective and Basics of Molecular Biology; Nathan R. Domagalski and Michael Domach

Biomolecular Interactions; Gordon Rule

Recent Advances in DNA Separations: Plasmid Purification, Rapid Electrophoresis, and Affinity-Based Recovery; James W. Schneider and Jeffrey M. Savard

Systems and Technology Involving Bacteria; Nicole Bleckwenn and William Bentley

Expression in Mammalian Cells; Tina Sauerwald and Michael Betenbaugh

DNA Vaccines Production and Engineering; Michael M. Domach, Jonathan W. Meade, and Mohammad A. Ataai

TRANSPORT PHENOMENA AND BIOMIMETIC SYSTEMS

Biomimetic Systems: Concepts, Design, and Emulation; Robert J. Fisher

Transport/Reaction Processes in Biology and Medicine; E. N. Lightfoot

Microvascular Heat Transfer; James W. Baish

Fluid Dynamics for Bio Systems: Fundamentals and Model Analysis; Robert A. Peattie and Robert J. Fisher

Animal Surrogate Systems; Michael L. Shuler, Sarina G. Harris, Xinran Li, and Mandy B. Esch

Arterial Wall Mass Transport: The Possible Role of Blood Phase Resistance in the Localization of Arterial Disease; John M. Tarbell and Yuchen Qiu

Transport Phenomena and the Microenvironment; Robert J. Fisher and Robert A. Peattie

Transport and Drug Delivery through the Blood–Brain Barrier and Cerebrospinal Fluid; Bingmei M. Fu

Interstitial Transport in the Brain: Principles for Local Drug Delivery; W. Mark Saltzman

Surfactant Transport and Fluid–Structure Interactions during Pulmonary Airway Reopening; David Martin, Anne-Marie Jacob, and Donald P. Gaver III

PHYSIOLOGICAL MODELING, SIMULATION, AND CONTROL

Modeling Strategies and Cardiovascular Dynamics; Joseph L. Palladino, Gary M. Drzewiecki, and Abraham Noordergraaf

Compartmental Models of Physiological Systems; Claudio Cobelli, Giovanni Sparacino, Maria Pia Saccomani, Gianna Maria Toffolo, and Andrea Caumo

Cardiovascular Models and Control; Madhusudan Natarajan, Fernando Casas, and W.D. Timmons

Respiratory Models and Control; Chi-Sang Poon

Biomimetic Approaches to Physiological Control; James J. Abbas and Amit Abraham

Methods and Tools for Identification of Physiologic Systems; Vasilis Z. Marmarelis

Modeling Vascular Vibrations: Autoregulation and Vascular Sounds; Gary M. Drzewiecki, John K.-J. Li, and Abraham Noordergraaf

External Control of Movements; Dejan B. Popovic´ and Mirjana B. Popovic

The Fast Eye Movement Control System; John Denis Enderle

A Comparative Approach to Analysis and Modeling of Cardiovascular Function; John K.-J. Li, Ying Zhu, and Abraham Noordergraaf

A Biomedical and Biophysical Approach to the Science in Cardiopulmonary Resuscitation; Gerrit J. Noordergraaf, Igor W. F. Paulussen, Alyssa Venema, Gert Jan Scheffer, and Abraham Noordergraaf

Kinematic Modeling of Left Ventricular Diastolic Function; Leonid Shmuylovich, Charles S. Chung, and Sándor J. Kovács

STEM CELL ENGINEERING: AN INTRODUCTION

Engineering the Pluripotent Stem Cell Niche for Directed Mesoderm Differentiation; Céline L. Bauwens, Kelly A. Purpura, and Peter W. Zandstra

Cell Mechanobiology in Regenerative Medicine: Lessons from Cancer; Badriprasad Ananthanarayanan and Sanjay Kumar

Systems-Engineering Principles in Signal Transduction and Cell-Fate Choice; Karin J. Jensen, Anjun K. Bose, and Kevin A. Janes

Biomaterial Scaffolds for Human Embryonic Stem Cell Culture and Differentiation; Stephanie Willerth and David Schaffer

Stem Cells and Regenerative Medicine in the Nervous System; Shelly Sakiyama-Elbert

Stem Cells and Regenerative Medicine for Treating Damaged Myocardium; Rohini Gupta, Kunal Mehtani, Kimberly R. Kam, and Kevin E. Healy

Stem Cells and Hematopoiesis; Krista M. Fridley and Krishnendu Roy

Synthetic Biomaterials and Stem Cells for Connective Tissue Engineering; Ameya Phadke and Shyni Varghese

Derivation and Expansion of Human Pluripotent Stem Cells; Sean P. Palecek

Bioreactors for Stem Cell Expansion and Differentiation; Carlos A. V. Rodrigues, Tiago G. Fernandes, Maria Margarida Diogo, Cláudia Lobato da Silva, and Joaquim M. S. Cabral

TISSUE ENGINEERING

Strategic Directions; Peter C. Johnson

Silks; Monica A. Serban and David L. Kaplan

Calcium Phosphates; Kemal Sariibrahimoglu, Joop G.C. Wolke, Sander C.G. Leeuwenburgh, and John A. Jansen

Engineered Protein Biomaterials; Andreina Parisi-Amon and Sarah C. Heilshorn

Synthetic Biomaterials; Joshua S. Katz and Jason A. Burdick

Growth Factors and Morphogens: Signals for Tissue Engineering; A. Hari Reddi

Signal Expression in Engineered Tissues; Martha O. Wang and John P. Fisher

Pluripotent Stem Cells; Todd C. McDevitt and Melissa A. Kinney

Hematopoietic Stem Cells; Ian M. Kaplan, Sebastien Morisot, and Curt I. Civin

Mesenchymal Stem Cells; Pamela C. Yelick and Weibo Zhang

Nanobiomaterials for Tissue Engineering; Pramod K. Avti, Sunny C. Patel, Pushpinder Uppal, Grace O’Malley, Joseph Garlow, and Balaji Sitharaman

Biomimetic Approaches in Tissue Engineering; Indong Jun, Min Sup Kim, Ji-Hye Lee, Young Min Shin, and Heungsoo Shin

Molecular Biology Techniques; X.G. Chen, Y.L. Fang, and W.T. Godbey

Biomaterial Mechanics; Kimberly M. Stroka, Leann L. Norman, and Helim Aranda-Espinoza

Mechanical Conditioning; Elaine L. Lee and Horst A. von Recum

Micropatterned Biomaterials for Cell and Tissue Engineering; Murugan Ramalingam and Ali Khademhosseini

Drug Delivery; Prinda Wanakule and Krishnendu Roy

Gene Therapy; C. Holladay, M. Kulkarni, W. Minor, and Abhay Pandit

Nanotechnology-Based Cell Engineering Strategies for Tissue Engineering and Regenerative Medicine Applications; Joaquim Miguel Oliveira, João Filipe Mano, and Rui Luís Reis

Cell Encapsulation; Stephanie J. Bryant

Coculture Systems for Mesenchymal Stem Cells; Song P. Seto and Johnna S. Temenoff

Tissue Engineering Bioreactors; Sarindr Bhumiratana, Elisa Cimetta, Nina Tandon, Warren Grayson, Milica Radisic, and Gordana Vunjak-Novakovic

Shear Forces; Jose F. Alvarez-Barreto, Samuel B. VanGordon, Brandon W. Engebretson, and Vasillios I. Sikavitsas

Vascularization of Engineered Tissues; Monica L. Moya and Eric M. Brey

Biomedical Imaging of Engineered Tissues; Nicholas E. Simpson and Athanassios Sambanis

Multiscale Modeling of In Vitro Tissue Cultivation; Kyriacos Zygourakis

Bone Engineering; Lucas A. Kinard, Antonios G. Mikos, and F. Kurtis Kasper

Dental and Craniofacial Bioengineering; Hemin Nie and Jeremy J. Mao

Tendon and Ligament Engineering; Nicholas Sears, Tyler Touchet, Hugh Benhardt, and Elizabeth Cosgriff-Hernández

Cartilage Tissue Engineering; Emily E. Coates and John P. Fisher

TMJ Engineering; Michael S. Detamore

Interface Tissue Engineering; Helen H. Lu, Nora Khanarian, Kristen Moffat, and Siddarth Subramony

The Bioengineering of Dental Tissues; Rena N. D’Souza, Katherine R. Regan, Kerstin M. Galler, and Songtao Shi

Tissue Engineering of the Urogenital System; In Kap Ko, Anthony Atala, and James J. Yoo

Vascular Tissue Engineering; Laura J. Suggs

Neural Engineering; Yen-Chih Lin and Kacey G. Marra

Tumor Engineering: Applications for Cancer Biology and Drug Development; Joseph A. Ludwig and Emily Burdett

ARTIFICIAL ORGANS

Artificial Heart and Circulatory Assist Devices; Gerson Rosenberg

Cardiac Valve Prostheses; Arjunon, Neelakantan Saikrishnan, and Ajit P. Yoganathan

Artificial Lungs; Keith E. Cook, Timothy M. Maul, and William J. Federspiel

Blood Substitutes; Amy G. Tsai, Pedro Cabrales, and Marcos Intaglietta

Liver Support Systems; Matthew S. Chang and Robert S. Brown

Peritoneal Dialysis Equipment; Carlo Crepaldi, Francesca Katiana Martino, Maria Pia Rodighiero, and Claudio Ronco

Artificial Skin and Dermal Equivalents; Dennis P. Orgill, Raul Cortes, and Ioannis V. Yannas

DRUG DESIGN, DELIVERY SYSTEMS, AND DEVICES

Physiological Barriers to Drug Transport; Fan Yuan

Nucleic Acid Aptamers in Drug Delivery; Mark R. Battig, Jing Zhou, and Yong Wang

Dendrimers for Drug Delivery; Giridhar Thiagarajan and Hamidreza Ghandehari

Noninvasive Targeted Protein and Peptide Drug Delivery; Pradeep K. Karla, Durga K. Paturi, Nanda K. Mandava, Animikh Ray, Sulabh Patel, Ranjana Mitra, and Ashim K. Mitra

Environment-Responsive Hydrogels for Drug Delivery; Byung Kook Lee, Jong-Ryoul Kim, Kinam Park, and Yong Woo Cho

Biodegradable PLGA Scaffolds for Growth Factor Delivery; Yusef Khan and Cato Laurencin

PERSONALIZED MEDICINE

Physiogenomic Contours: The Application of Systems Biology for Engineering Personalized Health Care; Andreas Windemuth, Richard L. Seip, and Gualberto Ruaño

The Evolution of Massively Parallel Sequencing Technologies: Facilitating Advances in Personalized Medicine; Ian Toma, Georges St. Laurent, III, Samuel Darko, and Timothy A. McCaffrey

Computational Methods and Molecular Diagnostics in Personalized Medicine; Roland Valdes, Jr. and Mark W. Linder

Need for Point-of-Care Testing Devices for Cardiac Troponin in Patients with Acute Coronary Syndromes; Alan H.B. Wu and Amy E. Herr

ETHICS

An Introduction to Bioethics and Ethical Theory for Biomedical Engineers; D. John Doyle

Biography

Joseph D. Bronzino is the founder and president of the Biomedical Engineering Alliance and Consortium (BEACON) in Hartford, Connecticut. He earned a PhD in electrical engineering from Worcester Polytechnic Institute in Massachusetts. Dr. Bronzino has received the Millennium Award from IEEE/EMBS and the Goddard Award from Worcester Polytechnic Institute for Professional Achievement. He is the author of more than 200 articles and 11 books.

Donald R. Peterson is a professor of engineering and dean of the College of Science, Technology, Engineering, Mathematics, and Nursing at Texas A&M University–Texarkana. He earned a PhD in biomedical engineering from Worcester Polytechnic Institute in Massachusetts. Dr. Peterson’s recent research focuses on measuring and modeling human, organ, and/or cell performance, including exposures to various physical stimuli and the subsequent biological responses. Dr. Peterson has published more than 50 journal articles and 12 reference books.