1st Edition

Biotechnology of Plasma Proteins

By Roger L. Lundblad Copyright 2013
460 Pages 20 B/W Illustrations
by CRC Press

460 Pages
by CRC Press

The fractionation of human blood plasma can be considered to be a mature industry, with the basic technology, alcohol fractionation, dating back at least to the 1940s. Many of the products described in the current work have been approved biologics since the 1950s. The information gathered from the development of plasma proteins has proved vital to the development of recombinant therapeutic... Read more

Blood, Plasma, Cells, and Other Biological Fluids

Plasma Fractionation and Plasma Protein Products

Methods for the Analysis of Plasma and Plasma Protein Fractions

Albumin
Structure of Albumin
In Vitro Chemical Modification of Albumin
Albumin as a Carrier
Ligand-Binding by Albumin
Purification and Characterization of HSA for Clinical Use
Biological Activity of Albumin
Enzymatic Activity of Albumin
Clinical Use of Albumin
Albumin as Diagnostic/Biomarker
Pharmacokinetics of Albumin
Analytical Methods for Albumin Including Use of Albumin as Standard for Analytical Methods
Albumin as Excipient
Conclusion
References

Plasma Immunoglobulins

Factor VIII and von Willebrand Factor
von Willebrand Factor
Economic Issues Impacting the Hemophilia Business
Conclusions and Future Directions
References

Plasma Proteinase Inhibitors
Antithrombin
α1-Antitrypsin (α1-Antiprotease Inhibitor, SERPINA1)
Heparin Cofactor II (SERPIND1)
α2-Macroglobulin
Tissue Factor Pathway Inhibitor
α2-Antiplasmin
C1-Inhibitor (C1-Esterase Inhibitor)
Plasminogen Activator Inhibitor-1
Protein C Inhibitor (Plasminogen Activator Inhibitor-3)
References

Vitamin K-Dependent Proteins

Miscellaneous Plasma Proteins
Fibrinogen
Fibrin Sealant
Autologous Fibrin Sealant
Fibrinogen and Tissue Soldering
Thrombin and Fibrin Foam
Fibrinogen Plastics
Thrombin
Plasminogen and Plasmin
Butyrylcholinesterase
Fibronectin
References

Biography

Roger L. Lundblad