3D Cell-Based Biosensors in Drug Discovery Programs: Microtissue Engineering for High Throughput Screening, 1st Edition (e-Book) book cover

3D Cell-Based Biosensors in Drug Discovery Programs

Microtissue Engineering for High Throughput Screening, 1st Edition

By William S. Kisaalita

CRC Press

404 pages

Purchasing Options:$ = USD
Paperback: 9781138112025
pub: 2017-06-13
Currently out of stock
Hardback: 9781420073492
pub: 2010-06-22
eBook (VitalSource) : 9780429146770
pub: 2010-06-22
from $39.98

FREE Standard Shipping!


Advances in genomics and combinatorial chemistry during the past two decades inspired innovative technologies and changes in the discovery and pre-clinical development paradigm with the goal of accelerating the process of bringing therapeutic drugs to market. Written by William Kisaalita, one of the foremost experts in this field, 3D Cell-Based Bio

Table of Contents

Introduction. Biosensors and Bioassays. Target-Driven Drug Discovery. 3D versus 2D Cultures. Comparative Genomics and Proteomics. Comparative Structure and Function. Emerging Design Principles. Chemical Microenvironmental Factors. Spatial and Temporal Microenvironmental Factors. Material Physical Property and Force Microenvironmental Factors. Proteomics as a Promising Tool in the Search for 3D Biomarkers. Readout Present and Near Future. Ready-to-Use Commercial 3D Plates. Technology Deployment Challenges and Opportunities. Challenges to Adopting 3D Cultures in HTS Programs. Cases for 3D Cultures in Drug Discovery. Ideal Case Study Design. Appendices. Index.

About the Author

William S. Kisaalita, PhD is professor and former coordinator of graduate engineering programs at the University of Georgia, where he also directs the Cellular Bioengineering Laboratory. The main research focus of his laboratory is cell-surface interactions with applications in cell-based biosensing in drug discovery. He has published more than 80 peer reviewed and trade press papers and made more than 100 poster and podium presentations. He has received numerous instructional awards including membership in the University of Georgia Teaching Academy. He is a member of ACS, AAAS, ASEE, and SBS. Dr. Kisaalita serves on the editorial boards of The Open Biotechnology Journal and The Journal of Community Engagement and Scholarship.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biotechnology
MEDICAL / Pharmacology
SCIENCE / Biotechnology