Advances in genomics and combinatorial chemistry during the past two decades inspired innovative technologies and changes in the discovery and pre-clinical development paradigm with the goal of accelerating the process of bringing therapeutic drugs to market. Written by William Kisaalita, one of the foremost experts in this field, 3D Cell-Based Bio
Introduction. Biosensors and Bioassays. Target-Driven Drug Discovery. 3D versus 2D Cultures. Comparative Genomics and Proteomics. Comparative Structure and Function. Emerging Design Principles. Chemical Microenvironmental Factors. Spatial and Temporal Microenvironmental Factors. Material Physical Property and Force Microenvironmental Factors. Proteomics as a Promising Tool in the Search for 3D Biomarkers. Readout Present and Near Future. Ready-to-Use Commercial 3D Plates. Technology Deployment Challenges and Opportunities. Challenges to Adopting 3D Cultures in HTS Programs. Cases for 3D Cultures in Drug Discovery. Ideal Case Study Design. Appendices. Index.