A Century of Mendelism in Human Genetics: 1st Edition (Hardback) book cover

A Century of Mendelism in Human Genetics

1st Edition

Edited by Milo Keynes, A. W. F. Edwards, Robert Peel

CRC Press

180 pages | 12 Color Illus. | 2 B/W Illus.

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pub: 2004-03-15
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Description

In 1901 William Bateson, Professor of Biology at Cambridge, published a renewed version of a lecture which he had delivered the year before to the Royal Horticultural Society in London (reprinted in the book as an appendix). In this lecture he recognized the importance of the work completed by Gregor Mendel in 1865, and brought it to the notice of the scientific world. Upon reading Bateson's paper, Archibald Garrod realized the relevance of Mendel's laws to human disease and in 1902 introduced Mendelism to medical genetics.

The first part of A Century of Mendelism in Human Genetics takes a historical perspective of the first 50 years of Mendelism, including the bitter argument between the Mendelians and the biometricians. The second part discusses human genetics since 1950, ending with a final chapter examining genetics and the future of medicine. The book considers the genetics of both single-gene and complex diseases, human cancer genetics, genetic linkage, and natural selection in human populations.

Besides being of general medical significance, this book will be of particular interest to departments of genetics and of medical genetics, as well as to historians of science and medicine.

Reviews

“… it brings together a dozen (mostly brief) essays by some of the most distinguished figures in human genetics. … As a group, the essays are notable both for their attention to the history of their field and for their sensitive treatment of delicate questions of gen-environment interaction and biochemical individuality. …”

—Nathaniel Comfort, History of Medicine, Johns Hopkins University, Baltimore, Maryland, in The Quartely Review of Biology, December 2006

Table of Contents

THE FIRST FIFTY YEARS OF MENDELISM

The Introduction of Mendelism into Human Genetics

Galton’s Theory of Ancestral Inheritance

The Reception of Mendelism by the Biometricians and the Early Mendelians

Mendelism and Man 1918 – 1939

The Darwin Lecture: William Bateson, Archibald Garrod and the Nature of the “Inborn”

HUMAN GENETICS FROM 1950

Linkage and Allelic Association

Malaria and Darwinian Selection in Human Populations

Chromosomal Genetics and Evolution

Mendelian Disorders in Man: The Development of Human Genetics

The Genetics of Complex Diseases

Human Cancer Genetics

Genetics and the Future of Medicine

APPENDIX

Subject Categories

BISAC Subject Codes/Headings:
MED039000
MEDICAL / History
SCI029000
SCIENCE / Life Sciences / Genetics & Genomics