A Manual of Neonatal Intensive Care: 5th Edition (Paperback) book cover

A Manual of Neonatal Intensive Care

5th Edition

By Janet M Rennie, Giles Kendall

CRC Press

424 pages | 100 B/W Illus.

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Paperback: 9780340927717
pub: 2013-07-29
Hardback: 9781138456990
pub: 2017-07-28
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pub: 2013-07-30
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Highly Commended, BMA Medical Book Awards 2014

The fifth edition of this highly successful and well-regarded book continues to provide those working in neonatal intensive care units with precise instructions on the diagnosis and management of common neonatal problems. This edition has been extensively updated and revised, while retaining the background physiology, key references, and diagrams that made previous editions so successful.

Several new chapters have been added, including the subjects of fetal medicine, antenatal diagnosis, and obstetrics for the neonatologist. Using a clear, accessible style, this edition features discussions of evidence-based medicine and the introduction of additional easy-to-digest lists. The text has been made more internationally applicable, including a re-focus of the chapter on organization of neonatal care away from UK-specific admission criteria and more towards general reasons for admitting a baby to the intensive care ward.

A Manual for Neonatal Intensive Care provides invaluable guidance for trainees in pediatrics, neonatology, and neonatal nursing and forms a useful ready-reference for the practicing pediatrician and nurse.


" … very well covered in a style that is easy to access, with some excellent diagrams illustrating the text well. The layout of the book is very well structured, making quick reference easy. It is the type of book that a practitioner can dip into quickly to access information about a topic and gain a basic concept in a short space of time."

—Sarah Carey, Deputy Sister, Peterborough City Hospital

"This is a well-balanced text that is user-friendly on the shop floor and provides a good level of explanatory detail. … . Every neonatal unit and paediatric trainee should have a copy of this book – it is a definitive text. Highly Commended."

—2014 BMA Medical Book Awards

" … a good starting point for nurses new to the neonatal setting as it gives good advice about aspects of care and basic information about most of the scenarios likely to be encountered in an easy to understand language. This is a delightful book to have in the neonatal unit library for all staff to access."

Practising Midwife

Table of Contents

Epidemiology and neonatal outcomes

Epidemiology: definitions in perinatal medicine

Neonatal outcomes


Further reading

Web links

Organization of neonatal care

Organization of neonatal care: definition of levels of care

Provision of intensive care facilities


Clinical governance, risk management and legal aspects of neonatal practice

Clinical Governance

Serious untoward incident (SUI) reporting and investigation

Medical negligence



Further reading

Maternal-fetal medicine for the neonatologist

Prenatal diagnosis of fetal disease

Maternal conditions affecting the fetus

Hypertension in pregnancy

Multiple pregnancy

Immunological conditions

Placental insufficiency

Preterm membrane rupture

Prelabour rupture of the membranes at term

Induction of labour

Intrapartum monitoring

Mode of delivery

Further information

Further reading

Genetic disease

Good ‘handles’ for genetic diagnosis

Further reading

Web links

Neonatal resuscitation and stabilization

Physiological adaptation at birth

Neonatal resuscitation

Resuscitation equipment

Practice of neonatal resuscitation

Special situations in neonatal resuscitation

Problems with resuscitation

First-hour care after resuscitation


Further reading

Nursing, monitoring and transport of the sick neonate

Thermal control

Minimal handling


Clinical and laboratory monitoring


Physical examination of the newborn

Timing of the examination

Physical examination of the newborn


Further reading

Congenital anomalies and common postnatal problems

Common findings in day-to-day practice


Further reading

Web link

Fluid and electrolyte balance

Neonatal renal function and physiology




Hydrogen ions and bicarbonate

Calcium and phosphate


Practical fluid and electrolyte management


Further reading

Neonatal enteral nutrition

Infant nutrient requirements

Which milk to give?

Anti-infection agents

Healthy LBW babies

Sick LBW babies


Further reading

Web link

Parenteral nutrition

Composition of parenteral nutrition solutions

Intravenous feeding solutions

Route of infusion

Monitoring of i.v. feeding

Complications of PN


Further reading

Acute disorders of the respiratory tract

Respiratory physiology

Differential diagnosis of neonatal respiratory disease

Respiratory distress syndrome (RDS); hyaline membrane disease (HMD)

Treatment of RDS

Continuous positive airways pressure (CPAP)

Mechanical ventilation: intermittent positive pressure ventilation


Sudden deterioration on IPPV

Gradual deterioration on IPPV

Transient tachypnoea of the newborn

Meconium aspiration

Pulmonary interstitial emphysema (PIE), pneumothorax, pneumomediastinum

Massive pulmonary haemorrhage

Persistent pulmonary hypertension of the newborn (PPHN)

Pulmonary hypoplasia

Congenital malformations affecting the respiratory tract


Further reading

Chronic lung disease

Interventions for chronic lung disease

Wilson–Mikity syndrome


Further reading

Apnoeic attacks

Definition of apnoea and periodic breathing

Clinically significant apnoea

Recurrent apnoea of prematurity





Further reading


Infection control in neonatal units

Host defences in the newborn and the inflammatory response

Bacterial infection in the newborn

Maintenance of homeostasis

Virus infections

Congenital infections

Effect of perinatal maternal infections


Further reading

Neurological problems

Assessment of the nervous system

Convulsions in the newborn

Hypoxic ischaemic encephalopathy (HIE)

Focal vascular lesions

Extracranial haemorrhage

Intracranial haemorrhage

Preterm white matter injury/periventricular leukomalacia (PVL)

Neonatal hypotonia

Nerve palsies

Central nervous system malformations

Metabolic disorders, including glucose homeostasis and inborn errors of metabolism

Glucose metabolism in the newborn

Clinical causes of hypoglycaemia

Unusual cases of neonatal hypoglycaemia

Neonatal hyperglycaemia

Inborn errors of metabolism

Causes of severe early metabolic disease


Further reading

Endocrine disorders


Congenital adrenal hyperplasia

Thyroid problems

Further reading

Neonatal jaundice and liver disease


Bilirubin biochemistry

Bilirubin encephalopathy (kernicterus)

Differential diagnosis of neonatal jaundice

Causes of unconjugated hyperbilirubinaemia

Breast feeding and jaundice

Some specific causes of unconjugated hyperbilirubinaemia

Prolonged neonatal jaundice

Prolonged unconjugated hyperbilirubinaemia

Conjugated hyperbilirubinaemia

Treatment of neonatal jaundice

Gastroenterological problems

Basic physiology of the fetal and neonatal gut

Cleft lip and palate

Oesophageal atresia and trachea-oesophageal fistula

Intestinal obstruction



Necrotizing enterocolitis

Isolated bowel perforation

Short bowel syndrome

Gastro-oesophageal reflux

The baby with persistent vomiting

Persisting diarrhea

Haematemesis, melaena and bloody stools in the newborn

Hirschprung’s disease


Further reading

Congenital heart disease in the neonatal period

The fetal circulation

Changes in the circulation at birth

Presentation of heart disease


Heart murmurs in asymptomatic babies

CHD presenting as shock with acidosis

CHD presenting as heart failure

Treatment of heart failure in the newborn

Individual conditions which can cause heart failure or shock

Cyanotic heart disease

Arrhythmias in the neonatal period


Arrhythmias in the neonatal period

Neonatal haematology

Anaemia in the neonate

Haemolytic disease of the newborn

Guidelines for DAT+ babies

Bleeding and bruising

Neonatal thrombosis


Web links

Genitourinary problems


Renal failure

Urinary tract infection

Congenital nephrotic syndrome

Renal malformations

Genitourinary tract anomalies


Further reading

Eye disorders

Retinopathy of prematurity

Buphthalmos (neonatal glaucoma)





Further reading

Skin disorders

Common benign neonatal skin disorders

Other miscellaneous neonatal skin conditions

Birthmarks and vascular disorders

Further reading

Orthopaedic and bone disorders



Skeletal malformations

Further reading

Neonatal abstinence syndrome

Maternal opiate abuse


Further reading

Procedures and iatrogenic complications

Neonatal procedures

Blood sampling and cannulation

Management of extravasation injury

Umbilical catherization

Intraosseous lines

Endotracheal intubation

Urine collection


Further reading

Appendix 1 Growth charts

Appendix 2 Assessing the ill neonate

Respiratory severity scoring

Clinical Risk Index for Babies – CRIB II score


Appendix 3 Normal blood pressure

Term neonates

Preterm infants


Appendix 4 The neonatal ECG

Rate and rhythm

The axis

Information about the atria

Information about the ventricles

Appendix 5 Normal biochemical values in the newborn

Appendix 6 Haematological values in the newborn


Appendix 7 Normal CSF values in the newborn

Traumatic lumbar puncture


About the Authors

Janet M Rennie, Consultant and Senior Lecturer in Neonatal Medicine, Elizabeth Garrett Anderson Obstetric Hospital, University College London Hospitals, UK

Giles Kendall, Academic Clinical Lecturer in Neonatal Neuroimaging and Neuroprotection, UCL Elizabeth Garrett Anderson Institute for Women's Health and University College London Hospitals, UK

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / General
MEDICAL / Perinatology & Neonatology