A Primate Model for the Study of Colitis and Colonic Carcinoma describes recent observations of the prevalence, pathogenesis, natural history, and time-course of idiopathic colitis and colonic carcinoma in the Cotton-Top Tamarin (CTT) model. Results of colonoscopy and mucosal biopsy are shown to evaluate the therapeutic efficacy of new anti-colitic agents. The contributions of antigenic profiles as a function of disease state, occurrence of extra-intestinal manifestations, and possible causal agents of colitis are also discussed. Prevalence of spontaneous CTT colonic carcinoma is considered from genetic influence, from promotion by colitis, and through the use of diagnostic and prognostic tools such as flow cytometry. Changes in fecal steroids, serum markers, colonic glycoprotein, polyamine metabolism, and immunobiology of CTTs are discussed in regard to disease condition. The book is an essential reference on the CTT model for gastroenterologists, oncologists, and all researchers interested in digestive diseases.
Part 1: Historical Background of Callitrichids 1. The Columbian Cotton-Top Tamarin in the Wild 2. Breeding the Cotton-Top Tamarin - Saguinus oedipus - in Captivity 3. Callitrichid Nutrition. Inflammatory Bowel Disease in Callitrichids 4. Natural History, Time Course, and Pathogenesis of Idiopathic Colitis in Cotton-Top Tamarins - Saguinus Oedipus 5. The Prevalence of Idiopathic Colitis in the New England Regional Primate Research Center Cotton-Top Tamarin - Saguinus oedipus 6. An Antigenic Profile in Cotton-Top Tamarins-Saguinus oedipus. A Model for Human Inflammatory Bowel Disease and Colorectal Cancer 7. Extra-Intestinal Manifestations of Cotton-Top Tamarin Colitis 8. A Protocol to Evaluate the Efficacy of Anti-Colitic Agents Against Ulcerative Colitis in Cotton-Top Tamarins 9. Coronaviruses in Tamarin and Marmoset Colitis 10. Do Repeated Colonic Mucosal Biopsies Impact Mortality in Cotton-Top Tamarins? Colon Carcinoma in Saguinus oedipus 11. Spontaneous Colonic Carcinoma Observations in the Oak Ridge Associated Universities 26-year-old Cotton-Top Tamarin (Saguinus oedipus) Colony 12. Genetic Epidemiology of Colon 13. Prevalence of Colonic Carcinoma in Cotton-Top Tamarin Colonies Throughout the World 14. Early Colonic Carcinoma Development in Cotton-Top Tamarins: Evidence of Promotion by Colitic Episodes? 15. Death Rates with Age from All Causes and Colonic Carcinoma and Causes in Wild-Caught and Colony-Born Cotton-Top Tamarins 16. Tamarin Colon Cancer and Flow Cytometry. Physiologic Changes and Markers Associated with Colon Disease 17. Fecal Steroids in Tamarins and Marmosets 18. A Serum Marker for Colon Cancer Detection: The Use of the Cotton-Top Tamarin 19. Colonic Glycoprotein Heterogeneity in the Cotton-Top Tamarin: Glycoconjugate Modification Associated with the Nonhuman Primate Model of Inflammatory Bowel Disease and Colonic Cancer 20. Polyamine Metabolism in Colonic Diseases 21. Immunobiology of the Cotton-Top Tamarin 22. Scintigraphic Imaging of Tamarin Colectoral Cancer with Radiolabeled Monoclonal Antibodies. E. Summary 23. Future Directions for Colon Disease Research Using Cotton-Top Tamarins