Provides an overview of the structure, transcription regulation and binding characteristics of cellular adhesion molecules and their ligands in the maintenance of function, immunological reactions and inflammatory processes with organ systems. The text examines the role of adhesion molecules in biological processes such as morphogenesis, blood coagulation, tumour metastasis, bone tissue remodelling and transplant rejection.
". . .an overwhelming compilation of facts and detailed information. . ..it should be available in the library of every medical school. "
Traffic signals on endothelium for lymphocyte recirculation and leucocyte emigration; strategies to inhibit cellular adhesion molecules; measurement of adhesion molecules in biological fluids; circulating adhesion receptors in health and disease; adhesion molecules as signal transduction molecules; adhesion molecules as mechanorecpetors; morphogenesis of epithelial cells; adhesion molecules in immunoregulation; regulation of endothelial selections and their ligands; role of chemoattractants in neurotrophil recruitment to sites of inflammation; adhesion molecules in lymphocyte-mediated; P-selectin and its ligands - structure and function; use of host adhesion molecules by infecting agents; modulation of leucocyte trafficking in infectious diseases; adhesion molecules in atherosclerosis; adhesion molecules in bone remodelling; adhesion molecules in tumour growth and metastasis; adhesion molecules in reperfusion injury; cellular adhesion molecules in neurology; adhesion molecules in inflammatory lung injury; role of adhesion molecules in intestinal inflammation; adhesion molecules in rheumatic disease; adhesion molecules in the immunopathogenesis of skin disease; adhesion molecules in renal diseases; adhesion molecules and artificial membranes; cellular and extracellular matrix adhesion in organ transplantation; adhesion molecules in defense of the peritoneum.