Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery: 1st Edition (Hardback) book cover

Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery

1st Edition

Edited by Chengtie Wu, Jiang Chang, Yin Xiao

CRC Press

244 pages | 8 Color Illus. | 70 B/W Illus.

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Hardback: 9781466551992
pub: 2013-03-22
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pub: 2013-03-22
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Bioceramics play an important role in repairing and regenerating defective or damaged bone. Annually, more than 500,000 bone graft procedures are performed in the United States and approximately 2.2 million are conducted worldwide. Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery reviews the latest advances in the field of bioceramics. The book summarizes innovative concepts, bioceramic design, and methods for material synthesis and drug delivery.

Offering guidance for biomedical engineering researchers and material scientists, the book explores:

  • Novel mesoporous bioactive glasses and silicate-based ceramics for bone regeneration and drug delivery
  • Bioactive silicate ceramics, including their mechanical properties, interaction with bone-forming cells, and in vivo osteogenesis and angiogenesis
  • Silica nanospheres with a core-shell structure and their specific properties for controllable drug delivery
  • The 3D-printing technique to prepare advanced bioceramic scaffolds for bone tissue engineering applications—including the preparation, mechanical strength, and biological properties of 3D-printed porous scaffolds of calcium phosphate cement and silicate bioceramics
  • Biomimetic preparation and controllable crystal growth and biomineralization of bioceramics
  • Inorganic and organic composite materials and their unique biological, electrical, and mechanical properties that enable the design of excellent bone regeneration and gene delivery systems

A comprehensive survey of the research progress of bioceramics and their applications in bone repair and regeneration, this volume is designed to enhance study and career development for those in this field and to facilitate further research and opportunities for new solutions.

Table of Contents

Mesoporous Bioactive Glasses for Drug Delivery and Bone Tissue Regeneration; Chengtie Wu, Jiang Chang, and Yin Xiao

Preparation, Compositions, and Main Forms of MBG

Drug and Growth Factor Delivery of MBG

Bone Tissue Engineering of MBG

Silicate-Based Bioactive Ceramics for Bone Regeneration Application; Chengtie Wu, Yin Xiao, and Jiang Chang

Preparation and Characterization of Silicate Bioceramics

Physicochemical and Self-Setting Properties of Silicate Ceramics

Biological Response of Bone-Forming Cells to Silicate Ceramics

In Vivo Bone-Forming Ability of Silicate Bioceramics

Functional Mesoporous Silica Nanoparticles with a Core-Shell Structure for Controllable Drug Delivery; Yufang Zhu

Functional Hollow Mesoporous Silica Nanoparticles for Controllable Drug Delivery

Functional Mesoporous Silica Nanoparticles with a Core-Shell Structure for Controllable Drug Delivery

3D Plotting of Bioceramic Scaffolds under Physiological Conditions for Bone Tissue Engineering; Yongxiang Luo, Anja Lode, Chengtie Wu, and Michael Gelinsky

3D Plotting of Calcium Phosphate Cement (CPC) Scaffolds

Polymer Reinforced Biphasic CPC–Alginate Scaffolds

3D Plotting of Silicon-Based Bioceramic Scaffolds

Biomimetic Preparation and Biomineralization of Bioceramics; Zhongru Gou, Ahmed Ballo, and Wei Xia

Biomimetic Preparation of Bioceramics

Biomineralization of Bioceramics

In Vitro and In Vivo Reaction of Biomimetic and Biomineralized Bioceramics

Preparation and Mechanism of Novel Bioceramics with Controllable Morphology and Crystal Growth; Kaili Lin and Jiang Chang

Bioactive Inorganic and Organic Composite Materials for Bone

Regeneration and Gene Delivery; Yufeng Zhang and Chengtie Wu

Bioactive Inorganic–Organic Composite Materials for Bone Regeneration

Gene Delivery


About the Editors

Chengtie Wu, Ph.D., works at the Shanghai Institute of Ceramics, Chinese Academy of Sciences. His research focuses on advanced bioactive inorganic materials for bone tissue engineering and drug delivery application. He has published more than 80 peer-reviewed journal papers, including 12 papers in Biomaterials, the top journal in the field of biomaterials. The published papers have been cited more than 900 times. Dr. Wu has been awarded five patents and two of his technology patents have been transferred to companies.

Jiang Chang, Ph.D., is the director of the Biomaterials and Tissue Engineering Research Center at the Shanghai Institute of Ceramics, Chinese Academy of Sciences. His research focuses on bioactive materials for tissue regeneration and tissue engineering. He has over 200 scientific papers published in international peer-reviewed scientific journals, including NanoLetters, Advanced Materials, European Cells and Materials, the Journal of Controlled Release, and Biomaterials.

Yin Xiao, Ph.D., is a biomedical scientist, dentist, and professor of medical engineering at Queensland University of Technology. Dr. Xiao has an international standing in the research areas of biomaterials, bone biology, tissue engineering, regenerative medicine, and orthopedic and dental research. He is a reviewer for a number of international and national grant bodies, an editorial board member on a series of scientific journals, and an invited reviewer of over 40 journals.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biotechnology