Advanced Genetics: 1st Edition (Hardback) book cover

Advanced Genetics

1st Edition

By Gurbachan S. Miglani

Narosa

665 pages

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Hardback: 9780849324253
pub: 2002-08-26
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Description

An advanced level volume for postgraduate students and researchers of genetics, cytogenetics biotechnology, biosciences, botany, and zoology which provides detailed coverage of mendelian, molecular, biochemical, immuno, human, mutagenesis, and evolutionary genetics. Concepts, principles and phenomena of genetics have been explained with the help of tables and figures including references, questions and numerical problems at the end of each chapter.

Table of Contents

INTERALLELIC AND INTERGENIC INTERACTIONS

Interallelic Interactions

Intergenic Inheritance

Totipotency

Pleiotropy

Homeostasis

NON-MENDELIAN INHERITANCE

Extranuclear Inheritance

Yeast Mitochondrial Genome

Universality of Genetic Code

Mitochondrial Genes and Diseases

Maternal Effects

Nucleocytoplasmic Interactions

Extrachromosomal Inheritance

Hybrid Dysgenesis

GENETICS OF SYMBIOSIS

Commensalism, Mutualism, and Parasitism

Kingdoms of Living Organisms

Endosymbionts and Ectosymbionts

Viruses in Bacteria

Agrobacterium and Crown Gall Disease

Nitrogen-Fixing Symbiosis

Host-Parasite Interactions

RECOMBINATION IN DROSOPHILA MALES

Complete Linkage in Drosophila Males

Fold-Back Elements of Drosophila

GENE AMPLIFICATIONS

Amplification During Differentiation and Development

Amplification by Selection

Amplification and Tumorigenesis

Amplification of Transferred Genes

Arrangement of Amplified Chromosomal DNA

Random vs Directed Gene Amplification

GENETIC CONTROL OF FUNCTION

Relationship Between Gene and Enzyme

Genetic Control of Biochemical Reactions

Relationship Between Genotype and Phenotype

One Gene-One Enzyme Hypothesis

One Gene-One Polypeptide Hypothesis

One Cistron-One Polypeptide

One Gene-One Primary Cellular Function Hypothesis

Pseudogenes

GENE EXPRESSION AND ITS ANALYSIS

Central Dogma and Its Reversal

Gene Expression

RNAs: Their Processing and Functions

Self-Splicing or rRNA in Tetrahymena

Genetic Code

Transcriptional Elements

Synergistic Gene Expression

Environmental Effects and Gene Expression

Hormones and Gene Expression

Penetrance and Expressivity

Phenocopies

Alternative RNA Splicing

Gene Silencing

GENETIC CONTROL OF PROTEIN SYNTHESIS

Translation in Prokaryotes

Translation in Eukaryotes

Fate of Completed Proteins

Protein Targetting

Protein Secretion

Molecular Chaperone

GENE REGULATION IN PROKARYOTES

Terminology of Gene Regulation

Mechanism of Gene Regulation in Prokaryotes

Antisense RNA in Prokaryotic Gene Regulation

Prokaryotic Gene Regulation by DNA Rearrangements

Alternative Sigma Factors

GENE REGULATION IN EUKARYOTES AND MODELS OF GENE

Is Operon Concept Applicable to Eukaryotes?

Short-Term Versus Long-Term Regulation

Mechanisms of Gene Regulation in Eukaryotes

Gene Regulation by Hormonal Action

DNA Methylation and Gene Regulation

Gene Control Levels in Eukaryotic Cells

Models of Gene Regulation

Transcriptional Initiation in Mammalian Genes

CAT-and TATA-binding Transcription Factors

Antisense RNA Strategies in Eukaryotes

Molecular Zippers in Gene Regulation

Regulation of Gene Expression by Small Molecules

Histones as Repressors of Gene Expression

Eukaryotic Gene Regulation Through DNA Rearrangements

Artificial Gene Repressors

Specificity in Eukayotic Gene Transcription

GENETIC ENGINEERING

Restriction Endonucleases

Gene/DNA Cloning

Gene Transfer Methods

Chromosome Walking/Jumping Libraries

Minisatellites and Microsatellites

Polymerase Chain Reaction

Transposon-Mediated Gene Transfer

High Density Molecular Maps

DNA Fingerprinting

LOD Score

Applications of Genetic Engineering

Hazards of Genetic Engineering

Gene Targetting

Transgenic Plants

Transgenic Animals

Expression and Stability of Genetically Engineered Genes

Genetically-Modified Food

Gene Chip Technology

GENE PATENTING

Requirements of Patentability

What Can Be Got Patented?

Patenting - An International Activity

Requirements for Depositing a Culture

Patenting for Life Forms

Selling the Sequences

Property Rights

Controversies on Genetic Manipulations

Patenting and Agricultural Industry

Economic Grains

Impact of Patenting on Less Developed Nations

Proposed Amendments on Patents Act, 1970

MAPPING QUANTITATIVE TRAIT LOCI

Reasons for Locating QTLs

Linkage of a Quantitative Trait to a Major Gene

Principle of QTL Mapping

Advanced Backcross of QTL Method

Mapping QTLs with MAPMAKER

Usefulness of QTL Mapping

Limitations of QTL Analysis

Fine Mapping of QTL

QTL Meta-Analysis

IMMUNOGENETICS

Immunoglobulins

Human Leukocyte Antigens

Vaccines

GENETIC DISORDERS IN MAN

Genetic Basis of Disorders

Disorders Due to Mutations

Diagnosis and Carrier Detection

Somatic Cell Hybridization

Treatment for Inherited Diseases

Gene Therapy

ONCOGENES AND ANTIONCOGENES

Retroviruses Contain Oncogenes

Proto-Oncogenes

src Oncogene

Origin of Oncogenes

Indentification of an Oncogene

Fine Structure of an Oncogene

Activation of Proto-Oncogenes

A Model of Carcinogenesis

Evidences Supporting Pall's Model

Antioncogenes

SEX DETERMINATION, DOSAGE COMPENSATION AND SEX DIFFERENTIATION

Sex-Determination

Noncoding DNA as Hypothesis for Sex-Determination

Dosage Compensation

Sex Differentiation

Events in Sex Determination

Human Sex Anomalies

EPIGENETICS AND MORPHOGENETICS

Epegenetic Patterns

Mutations and Epimutations

Cellular Transformation

Chromosome Imprinting

Epigenetic Defects and Ageing

DNA Methylation in Plants

Molecular Morphogenesis

Common Coding Motifs

Homeotic Genes in Flower Development

ORIGIN OF PROKARYOTIC AND EUKARYOTIC CELL

Organic Evolution

What is Life?

Theories of Origin of Life

Mechanism of Origin of Life on Earth

Evolution of Eukaryotes

Theories on the Origin of Eukaryote Cells

Evolution of Sexual Reproduction

PROCESS OF EVOLUTION

Lamark's Theory of Evolutio

Theory of Natural Selection

Mutation Theory of Evolution

Modern Synthetic Theory of Evolution

MOLECULAR EVOLUTION

Biological Species Concept

Genetics of Reproduction Isolation

Genetic Distance

An Era of Molecular Biology

Evolutionarily Important Genes

Molecular Evolutionary Clock

Genome Organization and Evolution

Selfish DNA

Molecular Drive

Proteome

Cryptic Variation

Establishment of New Patterns of Gene Control

Epochs of Molecular Evolution

GENOMICS

Assigning Function to a Gene

Tools to Study Functional Genomics

Potential Applications of Functional Genomics

Subject Categories

BISAC Subject Codes/Headings:
SCI029000
SCIENCE / Life Sciences / Genetics & Genomics
SCI072000
SCIENCE / Life Sciences / Biology / Developmental Biology