1st Edition

Advances in Drug Discovery Techniques

Edited By

Alan L. Harvey



  • This format is currently out of stock.
ISBN 9780471975090
Published August 15, 1998 by CRC Press
222 Pages

USD $350.00

Prices & shipping based on shipping country


Preview

Book Description

A guide to techniques for the discovery and evaluation of pharamcologically active compounds for therapeutic development, this book covers rational drug design, high-throughput screening, and genetic approaches to drug discovery. The authors focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. They examine typical screening studies and their link to robotics and informatics in detail and present an overview of current progress within anitsense therapeutics. The book explores the rapid changes in drug discovery resulting from developments in molecular biology, robotics, and informatics.

Table of Contents

Sense, Nonsense, and Antisense: Different Approaches to Drug Discovery, Alan L. Harvey
Introduction
Rational Drug Discovery
'Irrational' Drug Discovery
The Antisense Approach
Conclusions
References

Natural Problems for Drug Discovery: An Overview, Peter G. Waterman
Introduction
Secondary Metabolites
A Future for Natural Products in Drug Discovery?
Technical Problems in Using Natural Products in Random Screening
References

Advanced Screening Technology and Informatics for Normal Products Drug Discovery, Diana C. Hill
Introduction
Screening Technology
Advanced Informatics for Natural Products Drug Discovery
New Drug Templates from Natural Products
References

Discovery of Specific Tyrosine Kinase Inhibitors from Microbial and Botanical Sources, Gerald McMahon, Flora M. Tang, Tamotsu Furumai, K. Peter Hirth, and Toshikozu Oki
Drug Discovery and Extracts from Natural Sources
Inhibitors of Tyrosine Kinases from Natural Sources
Implementation of High Throughput Cell-Based RTK Assays
Primary Screening Results Using Plant and Microbial Extracts
Optimization of Specific RTK Inhibitory Activities in Fungal Extracts Using Fermentation Conditions
Acknowledgements
References

Plant Cell Culture: A Vehicle for Drug Discovery, Angela M. Stafford, Christopher J. Pazoles, Scott Siegel, and Li-An Yeh
Introduction
Plant Cell Culture Technology
Commercial Production Systems
Phytochemicals from Plant Cell Culture
Screening Plant Cell Cultures: Early Programmes
The Phytera Approach to lead Discovery: ExPANDÔ
Case Study: The Development of Anitfungal Drug Candidates
Acknowledgements
References

Pharmacy of the Deep - Marine Organisms as Sources of Anticancer Agents, Marcel Jaspars
Introduction
Aeroplysinin
Girolline
Halichondrin-B
Jasplakinolide
Didemnin-B
Ecteinascidin 743
Dolastatin-10
Bryostatin-1
Haloman
Future Directions
References

Drug Discovery by Using Molecular Biology to Reprogramme Microorganims, Iain S. Hunter
Introduction
Streptomycete Genetics and Molecular Biology
The Chemistry of Polyketide Biosynthesis
Molecular Genetics of Aromatic Polyketide Biosynthesis
Using Single Genes from Antibiotic Clusters as a Molecular Toolbox
Future Perspectives for the Combi-Gene Approach
References

Small Molecule Drug Screening Based on Surface Plasmon Resonance, Sanj Kumar and Kerstin Gunnarsson
Introduction
Principles of BIA
What Can BIA Measure?
A Tool in Drug Discovery
Conclusions
References

An Overview of Combinatorial Chemistry and Its Applications to the Identification of Matrix Metalloproteinase Inhibitors (MMPIs), Stephen J. Shuttleworth
Combinatorial Chemistry
Matrix Metalloproteinases (MMPs)
Combinatorial Synthesis of MMPIs
Conclusions
References

New Methods for Structure-Based De Novo Drug Design, Bohdan Waszkowycz
The Role of De Novo Design in Drug Discovery
General Methods and Consideration in De Novo Design
Synthetic Accessibility within PRO_SELECT
Conclusions
Acknowledgements
References

Current and Future Capabilities in Automated Drug Screening and Development, Ian J. Norrington
Introduction
General Considerations
Capabilities in High Throughput Screening
Preparation, Filtration, and Extraction
Molecular Biology
Combinatorial Chemistry
Full Automation
Costs and Returns
References

Antisense Oligonucleotide Therapeutics, C. Frank Bennett, Nicholas M. Dean, and Brett P. Monia
Introduction
First Generation Oligonucleotides
Clinical Experience with Antisense Oligonucleotides
Conclusions
References

Index

...
View More