Advances in Drug Discovery Techniques: 1st Edition (Hardback) book cover

Advances in Drug Discovery Techniques

1st Edition

Edited by Alan L. Harvey

CRC Press

222 pages

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Hardback: 9780471975090
pub: 1998-08-15
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Description

A guide to techniques for the discovery and evaluation of pharamcologically active compounds for therapeutic development, this book covers rational drug design, high-throughput screening, and genetic approaches to drug discovery. The authors focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. They examine typical screening studies and their link to robotics and informatics in detail and present an overview of current progress within anitsense therapeutics. The book explores the rapid changes in drug discovery resulting from developments in molecular biology, robotics, and informatics.

Table of Contents

Sense, Nonsense, and Antisense: Different Approaches to Drug Discovery, Alan L. Harvey

Introduction

Rational Drug Discovery

'Irrational' Drug Discovery

The Antisense Approach

Conclusions

References

Natural Problems for Drug Discovery: An Overview, Peter G. Waterman

Introduction

Secondary Metabolites

A Future for Natural Products in Drug Discovery?

Technical Problems in Using Natural Products in Random Screening

References

Advanced Screening Technology and Informatics for Normal Products Drug Discovery, Diana C. Hill

Introduction

Screening Technology

Advanced Informatics for Natural Products Drug Discovery

New Drug Templates from Natural Products

References

Discovery of Specific Tyrosine Kinase Inhibitors from Microbial and Botanical Sources, Gerald McMahon, Flora M. Tang, Tamotsu Furumai, K. Peter Hirth, and Toshikozu Oki

Drug Discovery and Extracts from Natural Sources

Inhibitors of Tyrosine Kinases from Natural Sources

Implementation of High Throughput Cell-Based RTK Assays

Primary Screening Results Using Plant and Microbial Extracts

Optimization of Specific RTK Inhibitory Activities in Fungal Extracts Using Fermentation Conditions

Acknowledgements

References

Plant Cell Culture: A Vehicle for Drug Discovery, Angela M. Stafford, Christopher J. Pazoles, Scott Siegel, and Li-An Yeh

Introduction

Plant Cell Culture Technology

Commercial Production Systems

Phytochemicals from Plant Cell Culture

Screening Plant Cell Cultures: Early Programmes

The Phytera Approach to lead Discovery: ExPANDÔ

Case Study: The Development of Anitfungal Drug Candidates

Acknowledgements

References

Pharmacy of the Deep - Marine Organisms as Sources of Anticancer Agents, Marcel Jaspars

Introduction

Aeroplysinin

Girolline

Halichondrin-B

Jasplakinolide

Didemnin-B

Ecteinascidin 743

Dolastatin-10

Bryostatin-1

Haloman

Future Directions

References

Drug Discovery by Using Molecular Biology to Reprogramme Microorganims, Iain S. Hunter

Introduction

Streptomycete Genetics and Molecular Biology

The Chemistry of Polyketide Biosynthesis

Molecular Genetics of Aromatic Polyketide Biosynthesis

Using Single Genes from Antibiotic Clusters as a Molecular Toolbox

Future Perspectives for the Combi-Gene Approach

References

Small Molecule Drug Screening Based on Surface Plasmon Resonance, Sanj Kumar and Kerstin Gunnarsson

Introduction

Principles of BIA

What Can BIA Measure?

A Tool in Drug Discovery

Conclusions

References

An Overview of Combinatorial Chemistry and Its Applications to the Identification of Matrix Metalloproteinase Inhibitors (MMPIs), Stephen J. Shuttleworth

Combinatorial Chemistry

Matrix Metalloproteinases (MMPs)

Combinatorial Synthesis of MMPIs

Conclusions

References

New Methods for Structure-Based De Novo Drug Design, Bohdan Waszkowycz

The Role of De Novo Design in Drug Discovery

General Methods and Consideration in De Novo Design

Synthetic Accessibility within PRO_SELECT

Conclusions

Acknowledgements

References

Current and Future Capabilities in Automated Drug Screening and Development, Ian J. Norrington

Introduction

General Considerations

Capabilities in High Throughput Screening

Preparation, Filtration, and Extraction

Molecular Biology

Combinatorial Chemistry

Full Automation

Costs and Returns

References

Antisense Oligonucleotide Therapeutics, C. Frank Bennett, Nicholas M. Dean, and Brett P. Monia

Introduction

First Generation Oligonucleotides

Clinical Experience with Antisense Oligonucleotides

Conclusions

References

Index

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
MED072000
MEDICAL / Pharmacy