Advances in the Neuroscience of Addiction: 1st Edition (Hardback) book cover

Advances in the Neuroscience of Addiction

1st Edition

Edited by Cynthia M. Kuhn, George F. Koob

CRC Press

242 pages | 8 Color Illus. | 74 B/W Illus.

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Understanding the phenomenon of long-lasting vulnerability to addiction is essential to developing successful treatments. Written by an international team of authorities in their respective fields, Advances in the Neuroscience of Addiction provides an excellent overview of the available and emerging approaches used to investigate the biologic mechanisms of drug addiction. It also delineates the promising research discoveries being made in relapse prevention.

The book begins with current animal models of addiction, which mimic the state of humans entering treatment: recently-abstinent animals that receive common triggers for relapse (classical conditioning, stress, and neuroadaptive dysregulation). Coverage then shifts to the use of electrophysiologic approaches, which enable researchers to characterize the discharge patterns of single neurons during drug self-administration. After exploring advances in voltammetry and enzyme-linked biosensors for measuring glutamate, the book discusses the theoretical background and results of neuroimaging studies related to neuronal networks that are activated by drug-specific cues. It then describes modern genetic approaches to manipulate target proteins that influence addictive behavior.

The book rounds out its coverage by illustrating how a neuroeconomic approach can inform studies of reward processing in general and addiction in particular. It is a comprehensive introduction to the methodologies of the field for students and beginning researchers and an essential reference source for established investigators.


"In short, this volume introduces a host of important advances in the measurement of addictive processes at the genetic, physiological, neural, behavioral and psychological levels, as well as a wide variety of fascinating findings that will certainly play a major future role in both pure research and the pragmatics of treating addiction. Researchers at the forefront of addiction research will certainly want to consider the potential applications of these tools and findings for their own research."

—Metapsychology, 2011

Table of Contents

Advances in Animal Models of Relapse for Addiction Research

Friedbert Weiss

Application of Chronic Extracellular Recording Method to Studies of Cocaine Self-Administration: Method and Progress

Laura L. Peoples, Alexai V. Kravitz, and Karine Guillem

Neurochemistry of Addiction: Monitoring Essential Neurotransmitters of Addiction

Stefan G. Sandberg and Paul A. Garris

Alcohol Craving and Relapse Prediction: Imaging Studies

Andreas Heinz, Anne Beck, Jan Mir, Sabine M. Grüsser, Anthony A. Grace, and Jana Wrase

Integrating Behavioral and Molecular Approaches in Mouse:Self-Administration Studies

Danielle L. Graham and David W. Self

Neuroeconomics: Implications for Understanding the Neurobiology of Addiction

Michael L. Platt, Karli K. Watson, Benjamin Y. Hayden, Stephen V. Shepherd, and Jeffrey T. Klein

About the Editors

Cynthia M. Kuhn, Duke University Medical Center, Durham, North Carolina, USA

George F. Koob, The Scripps Research Institute, La Jolla, California, USA

About the Series

Frontiers in Neuroscience

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology
MEDICAL / Psychiatry / General
SCIENCE / Life Sciences / Neuroscience