Age-Related Macular Degeneration, Third Edition: 3rd Edition (Hardback) book cover

Age-Related Macular Degeneration, Third Edition

3rd Edition

Edited by Jennifer I. Lim

CRC Press

406 pages

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Hardback: 9781841849492
pub: 2012-11-15
eBook (VitalSource) : 9780429098253
pub: 2012-11-15
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The value of Age-Related Macular Degeneration has stood the test of time, but progress in both basic and clinical ophthalmology has been relentless, mandating the need for an updated book. This second edition focuses on the pathophysiology and the epidemiology of age-related macular degeneration (AMD), the clinical features and management of dry and wet AMD, imaging techniques, and medical therapy for both non-neovascular AMD and neovascular AMD. It describes both clinically validated and experimental therapies as well as rehabilitation technology, and presents strategies to prevent the progression of non-exudative AMD. Results from current clinical trials are also included.

New chapters in this edition cover:

  • Genetics and treatment
  • Oxidative stress and its relation to the pathophysiology of AMD and CNV (choroidal neovascularization—a common symptom of wet AMD)
  • Polypoidal choroidal vasculopathy
  • Microperimetry and psychophysical testing and ways to track geographic atrophy progression
  • Non-VEGF pathways
  • Retinal stem cells


"Professor Lim has brought us up to the moment. We owe her and her collaborators a vote of thanks and a vote of confidence. Hopefully, the march of time, with its inexorable acquisition of new knowledge, will mandate the need for yet another edition. For the time being, however, this Third Edition of Age-Related Macular Degeneration does its job commendably and effectively." Morton F. Goldberg, M.D., Director Emeritus The Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, Maryland USA

Table of Contents

Pathophysiology and Epidemiology of AMD

Histopathology of Age-Related Macular Degeneration

Immunology of Age-Related Macular Degeneration

Genetics of Age-Related Macular Degeneration

Choroidal Neovascularization: VEGF Pathways

Risk factors for Age-Related Macular Degeneration and Choroidal Neovascularization

Oxidative Stress

Clinical Features of AMD

Geographic Atrophy

Non-Neovascular Age-Related Macular Degeneration

Neovascular Age-Related Macular Degeneration

Polypoidal Choroidal Vasculopathy

Variants of Neovascular Age-related Macular Degeneration: Type 3 Neovascularization (Intra-retinal Neovascularization or Retinal Angiomatous Proliferation)

Imaging Techniques for the Clinical Evaluation of AMD

Fluorescein Angiography in Age-related Macular Degeneration

Indocyanine Green Angiography in Age-Related Macular Degeneration

Optical Coherence Tomography in the Evaluation of Age-Related Macular Degeneration

How to Analyze OCT images for Management of Neovascular AMD

Fundus Autofluorescence Imaging in Age-Related Macular Degeneration

Microperimetry and Psychophysical Testing to Aid in Determination of Progression of AMD

Current and Experimental Medical Treatment for Neovascular AMD

Laser Photocoagulation for Choroidal Neovascularization

Anti-VEGF drugs and Clinical trials

Non-VEGF Related Anti-Angiogenesis Pathways for Treatment of AMD

Radiation Therapy Treatment in Age-Related Macular Degeneration

Combination Therapy for AMD

Photodynamic Therapy for Neovascular AMD

Photocoagulation of AMD-Associated CNV Feeder Vessels

Macular Translocation and Other Surgical Treatments

Current and Experimental Medical Treatment for Non-Neovascular AMD and Geographic Atrophy

Prophylactic Treatment: The AREDS Study Results

Visual Cycle Modulation

Cellular Transplantation for Advanced Age-Related Macular Degeneration

Novel Therapeutic Interventions: Stem Cell

Rehabilitation of the Eye

Clinical Considerations for Visual Rehabilitation

Visual Prostheses for Age-Related Macular Degeneration

Development of Research Protocols in AMD

Clinical Research Trials

About the Editor

Jennifer I. Lim, M.D. is a professor of ophthalmology, Department of Ophthalmology; Director of the Retina Service; Marion H. Schenk, Esq. Chair in Ophthalmology for Research of the Aging Eye, at the University of Illinois at Chicago.

Dr Lim has contributed to over 90 courses, and has published over 200 academic papers, contributed to over 20 book chapters and published 4 books in total. She has given over 150 presentations at scientific meetings and has been invited to over 130 lectures/visiting professorships. Dr Lim is a reviewer for a number of academic journals including the American Journal of Ophthalmology, Retina, and the British Journal of Ophthalmology. She is currently a committee member for the Macula Society, American Society of Retinal Specialists, and American Academy of Ophthalmology.

Recent Awards:

•Marion H. Schenk, Esq., Chair in Ophthalmology for Research of the Aging Eye, 2010

•Best Doctors in America 2010-2011 (initially and continuously selected since 1994)

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Geriatrics
MEDICAL / Surgery / General