Alcohol clearly plays key roles in the promotion of cancers initiated by carcinogens. Thus, it is a major cause or significant contributing factor to many cancers. Ethanol affects the metabolism of anticancer drugs. It significantly contributes to viral hepatitis and liver cancer. In addition it modulates colorectal carcinogenesis, procarcinogen activation and risk of oral cancers. The mechanisms of ethanol's actions in carcinogen activation, and alcohol-related cancers are extensively reviewed. This book is designed for the researcher trying to understand how alcohol causes cancer, as well as the clinician/epidemiologist wishing to know more about its role in human cancer incidence.
CONTENTS: Mechanisms of Alcohol-Related Cancers (Siraj I. Mufti). Modulation of Nitrosamine Metabolism by Ethanol: Implications for Cancer Risk (Lucy M. Anderson). Effect of Ethanol on Procarcinogen Activation (H.K. Deitz and B. Osswald). The Role of Ethanol in Esophageal Carcinogenesis (David H. Barch and Linas M. Klygis). The Role of Hepatitis Viruses in the Genesis of Hepatocellular Carcinoma in Alcoholic Cirrhotics (B. Nalpas and C. Brechot). Ethanol and Risk of Cancer of the Oral Cavity, Pharynx and Esophagus (Silvia Franceschi and Carlo La Vecchia). Alcohol Effects on Anticancer Drugs Metabolism (E.A. de Bruijn and Th.J. Slee). Alcohol, Viral Hepatitis and Hepatocellular Carcinoma (Erica Villa, Margherita Melegari, and Federico Manenti). Alcohol and Colorectal Carcinogenesis (H.K. Seitz and U.A. Simanowski). Alcohol and Hepatocellular Carcinoma (Kunihiko Ohnishi). Alcoholic Liver Disease: Histopathology (R. Sciot and V.J. Desmet).