Amyotrophic lateral sclerosis or motor neurone disease is one of the most debilitating and devastating of the neurological diseases. The only comprehensive textbook available on the topic, this completely reorganized and expanded new edition examines all aspects of ALS from pathology to patient care and provides the reader with a ready reference to help with the difficulties encountered in patient diagnosis and treatment. Undoubtedly an important work in the field, this book will be of great interest to clinical neurologists and trainees, and to all those concerned with the care of people with ALS.
"…an extremely good book. The chapters are authoritative, clearly written, relatively concise, and well referenced. Although this book is a second edition, it is not mean to replace, but rather to supplement, the first edition."
-Doody's Review Services
"…The current edition is not merely an update of the first one; new authors have been recruited and chapter titles reflect changing concepts of pathogenesis….It is difficult to think of any important topics that have been omitted. Clinicians working with patients, the patients and their families, and investigators will appreciate this new, up-to-date, thorough, and handsomely produced volume."
-Lewis P. Rowland, Eleanor and Lou Gehrig MDA/ALS Center, Neurological Institute,
Columbia University Medical Center, New York, New York
The Spectrum of Motor Neuron Disorders. Epidemiology of Amyotrophic Lateral Sclerosis. Neuroimaging in ALS. Motor Unit Number Estimation in ALS. The corticomotoneuronal system in ALS. Conventional Neurophysiology in ALS. The Neuropsychology of ALS. Familial motor neuron diseases other than ALS. ALS Genetics with Mendelian Inheritance. Modifying Genes in ALS. From Genetic Defects to Molecular Pathogenesis of Memory and Movement Disorders. Transgenic Mouse and Mutagenesis Models. Apoptotic Cell Death Pathways in Amyotrophic Lateral Sclerosis: A Review. Ageing and Neurodegeneration. Neurotrophic Factors. Axonal transport and ALS. Mitochondrial dysfunction and energy metabolism in ALS. Therapeutic Trials in ALS: Past, Present and Future. Palliative care and quality of life with ALS