Hematology data from in vivo toxicology studies remains one of the most predictive measures for human risk, as the same measurements made in pre-clinical toxicology studies can be made in early clinical trials.
Covering the three main blood cell types – erythrocytes, leukocytes and thrombocytes, this work is designed to clarify topics for new entrants to the fields of laboratory animal hematology and toxicology, especially those topics where the rules for human hematology do not always apply. An entire chapter is devoted to immunotoxicology, a scientific discipline that is closely aligned with hematology.
The text also addresses pre-analytical and analytical variables that affect animal studies, as these play a far more important part when interpreting data in contrast to humans where many of these variables can be well controlled or have less physiological effect. Information has been collated from published papers, textbooks and unpublished data: Readers are provided with key references to encourage further study
Table of Contents
Introduction. Hemopoiesis. Pre-analytical Factors, Analytical Factors, Statistics. Bone Marrow Evaluation. Iron, Tranferrin, Vitamin B12, Folate, and Erythropoietin. Erythrocytic Disorders. Leukocytic Disorders. Hemostasis. Immunological Toxicology.
Following several senior positions and 13 years in health service laboratories, G. O. Evans left the post of principal clinical chemist at Birmingham Children’s Hospital, England, to enter the field of laboratory animal toxicology and clinical pathology. He was head of clinical pathology at Wellcome Research Laboratories, Beckenham, England, moving to join Astra Charnwood, and later the two AstraZeneca sites in the United Kingdom as director of clinical pathology.
Evans is now a director of A. George Owen and Company. He was the editor of and a contributor to a number of chapters of the book Animal Clinical Chemistry: A Primer for Toxicologists. In addition to lecturing at various universities in the UK, he has published over 40 papers on animal clinical pathology and toxicology. Other activities have included membership on the editorial board of the journal Laboratory Animals for over 15 years, and he has served as scientific secretary, chairman, and now is a lifetime honorary member of the Association of Comparative Clinical Pathology, UK.