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Antibodies have always been vital to any major progress within immunology. From diagnostic tools to vehicles for modern therapy against cancer, infections, and autoimmune diseases, antibodies serve many purposes, yet our knowledge of them, their properties, and structural characteristics is still incomplete.
A comprehensive review of topics of contemporary interest for specialists in B cell immunology, this volume investigates such topics as aspects of antibody-protein antigen interactions; immunoglobin genes; genome organization and expression; and intrabodies. Exciting, innovative technological developments used for exploring new areas of study and medical applications are also covered. Traditional aspects of the field are revisited so that relevant information and concepts are maintained as a point of reference to more modern aspects.
Table of Contents
1. Intrabodies: From Antibody Genes to Intracellular Immunization 2. The Murine Immunoglobin Kappa Locus: Insights into Genome Organization and Expression 3. Bispecific Antibody Engineering 4. Antibiobodies: Antibiotic Internal-Image Antibodies 5. The Structural and Thermodynamic Basis of Antibody-Protein Antigen Interactions 6.
Phage Antibody Display Libraries: A Tool to Search for Novel Cell-Surface Molecules 7. Immunization with Immunoglobin Genes