Antimicrobial/Anti-Infective Materials: Principles and Applications, 1st Edition (Hardback) book cover

Antimicrobial/Anti-Infective Materials

Principles and Applications, 1st Edition

Edited by Samuel P. Sawan, Gurusamy Manivannan

CRC Press

346 pages

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Hardback: 9781566767941
pub: 1999-12-10
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Description

As our consciousness of microbes increases, it appears that our desire to control our interactions with germs also increases in proportion. This is clearly demonstrated by examining the incredible growth in the number and sales volume of consumer products with antimicrobial claims. In the medical field as well, there is much interest in the use of antimicrobial/anti-infective materials for medical devices and general healthcare applications.

Antimicrobial/Anti-Infective Materials: Principles, Applications and Devices represents the best current research and practice on ways to reduce infection caused by devices inserted into the human body. This volume presents important recent developments in the research, development, and applications of anti-infective materials for use in medical devices. It includes 15 in-depth reports by more than 40 leading specialists in biomaterials and medical devices that cover a wide range of important advances in various materials and applications. These include improved coatings and surface modifications techniques, improved materials designed for inherent infection resistance, and applications in the areas of cardiac, orthopedic, ENT, and vascular devices.

This book serves the information needs of all those involved in the research, development, design, and selection of biomaterials and medical devices. It will benefit anyone who designs, uses, and monitors anti-infective materials, as well as those who develop and apply products made from these materials.

Reviews

This is a book that deserves a place on the bookshelf of any pharmaceutical scientist working on the development of solid dosage forms.

Pharmaceutical Research, vol. 18, no. 9, September 2001

Table of Contents

PERSPECTIVES ON INFECTIOUS DISEASE CHALLENGES AND ANTIMICROBIAL ANSWERS

Antimicrobials

Mode of Action and Interaction

Host-Parasite Relationship

Infectious Disease Challenges

Foodborne Diseases and Related Issues

Antimicrobial Drug Resistance and Related Issues

Rational Use of Antimicrobials

Device-Related Infections

INFECTIONS OF INTRACARDIAC DEVICES

Cardiac Pacemakers

Implantable Cardioverter Defibrillators

Left Ventricular Assist Devices

Prosthetic Cardiac Valves

INFECTIONS IN ORTHOPAEDICS

Osteomyelitis: Definition, Classification, and Relationship to Orthopaedic Devices

Etiology and Establishment of Infections on Orthopaedic Devices

Conventional Diagnostic and Treatment Regimens for Osteomyelitis

Alternative Approaches to Infection Treatment and Prophylaxis

Implant Surfaces That Are Passive and/or Anti-Adhesive

Regulatory Issues

PHYSIOCHEMICAL BASIS OF BACTERIAL ADHESION TO BIOMATERIAL SURFACES

Bacterial Adhesion as a Dynamic Process

Properties and Structure of Bacterial Cell Surfaces

Non-Specific Adhesion Mechanisms

Specific Adhesion Mechanisms

Other Factors Affecting Adhesion

ALBUMIN AFFINITY COATINGS MAY PREVENT FOREIGN-BODY INFECTIONS

Foreign-Body Infections

Protein Adsorption

Blood Coagulation

Fibronolysis

Platelet Adhesion

Microbial Adhesion

Medical-Device Coatings

IMMOBILIZED BIOCIDES AS AN ALTERNATIVE STRATEGY FOR CONTROL OF MICROBIAL CONTAMINATION

Synthesis of the Immobilized Peptide Systems

Biological Activity

Chemical and Physical Stability

Discussion and Implications

ANTI-INFECTIVE COATINGS REDUCE DEVICE-RELATED INFECTIONS

Biology on the Surfaces of Indwelling Devices

Anti-Infective Medical Devices by Surface Treatment o Further Research

REDUCED IMPLANT-RELATED INFECTIOUS COMPLICATIONS BY SURFACE MODIFICATION PROVIDING CONTROLLED ANTIMICROBIAL RELEASE

Surface Modification for Controlled Gentamicin Release

Animal Studies-Safety and Efficacy Testing

A CHEMICALLY INTELLIGENT INFECTION-RESISTANT COATING

Anti-Infective Coating Exhibiting Chemical Intelligence

Mechanism of Action

Coating Stability

Bacterial Grow Through Resistance in Coated Microporous Membranes

Efficacy Against Biofilms

MERGING OF BIOMEDICAL AND TEXTILE TECHNOLOGIES IN ORDER TO CREATE INFECTION-RESISTANT PROSTHETIC VASCULAR GRAFTS

Infection of Prosthetic Vascular Grafts

Efforts to Combat Graft Infection

Textile Dyes Versus Antibiotics: Structural and Chemical Similarities

Fluoroquinolone Antibiotics

Interaction of Fibers and Small Molecules

Application of Fluoroquinolones to Polyester via Pad/Heat Dyeing

ASEPTIC APPROACHES AND NOVEL ANTIMICROBIAL CATHETERS FOR PREVENTION OF INFECTION OF VASCULAR CATHETERS

Aseptic Approaches

Novel Anti-Infective Catheters

ANTI-INFECTIVE DEVICES IN OTOLARYNGOLOGY: CURRENT APPLICATIONS AND FUTURE OPPORTUNITIES

Otology: Trans-Tympanic Ventilation Tubes

Present Examples of Anti-Infective Ventilation Tubes

Laryngology: Airway Management Devices and Voice Protheses

Rhinology: Nasal Packing, Sinus Stents, and Nasal Septal Buttons

LABORATORY METHODS FOR ANTIMICROBIAL SUSCEPTIBILITY TESTING: INDICATIONS FOR SUSCEPTIBILITY TESTING

Susceptibility Test Methods

Special Susceptibility Tests

Selection and Reporting of Antimicrobial Agents

Emerging Resistance Problems

TOWARD DOLLAR DEVICES FOR MEASURING METABOLIC BIOCHEMISTRY

A "Simpler" Approach to Bioluminescence-Based Analysis

The ATP Platform

Substrate Specific Sensors

Multi-Analyte Panels

Samples

Other Technologies

SISYPHUS IN THE MICROBIAL WORLD: ANTIMICROBIAL STRATEGIES AND HUMANITY'S HEALTH

Role of Science and Technology in Epidemiological Shifts in Human History

Multidimensional Antimicrobial Strategies: Coping with the Global Threat of Antimicrobial Resistance

Antimicrobial Strategies Through the Lens of the Law

Science, Antimicrobial Strategies, and Future Plagues

Index

Subject Categories

BISAC Subject Codes/Headings:
TEC021000
TECHNOLOGY & ENGINEERING / Material Science