Antisense Research and Applications: 1st Edition (Hardback) book cover

Antisense Research and Applications

1st Edition

By Stanley T. Crooke, Bernard Lebleu

CRC Press

624 pages

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Hardback: 9780849347054
pub: 1993-05-27
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Antisense Research and Applications is a comprehensive review of oligonucleotide research covering molecular biological advances in this field, the current status of antisense drug research, and strategies for future research and therapeutic applications.

In bringing together the latest research from an array of authoritative scientists, Antisense Research and Applications provides an integrated conceptual basis for considering oligonucleotide therapeutics. Topics covered in the 32 chapters of this book include nucleic acid structure and function, antisense RNA, medicinal chemistry of oligonucleotides, analogs, pharmacokinetics and toxicology, and activities of current antisense drugs.

This volume addresses advances in a broad range of disciplines and is an excellent resource for basic researchers and applied investigators in pharmaceutical laboratories and in such fields as biochemistry and molecular biology.

Table of Contents

Introduction. Nucleic Acid Structure and Function. Antisense RNA. Medicinal Chemistry of Oligonucleotides. First Generation Analogs. Newer Analogs. Mechanisms of Action of Current Synthetic Oligonucleotides. Pharmacokinetics and Toxicology. Activities of Current Antisense Drugs. Index.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology