The impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expanded to investigate the key role it is now believed to play in hematopoiesis, angiogenesis, inflammation and organ remodelling. It is hoped that, with an increase in our understanding of the mechanisms controlling apoptosis, there will come the development of a new class of drugs which can pharmacologically manipulate apoptosis and thus provide a means to treat important diseases which currently pose problems to our society.
Containing papers presented at the Eleventh SmithKline Beecham Pharmaceuticals United States Research Symposium and with contributions from leading researchers, Apoptosis in Health and Disease offers a comprehensive review of important developments and research in the field.
Table of Contents
1. Caspase Activation in the Cardiomyocyte 2. Apoptosis and Autoimmune Disease 3. Ischemic Neuronal Death is NOT by Classic Apoptosis 4.The Role of Caspases in Apoptosis in Vitro Studied by Gene Targeting 5. Why Artherosclerotic Vessels Narrow and Re-narrow 6. Death-associated Proteins 7. Abortive Apoptosis as a Mechanism for Resistance to Cancer Therapy 8. Apoptosis in Cardiac Diseases 9. Pharmacological Regulation of Vascular Smooth Muscle Cell Apoptosis 10. Pathways of Neural Apoptosis 11. Caspases Activation Pathways in Neuronal Death in Stroke 12. The Role of Caspases in Cell Death after Brain Ischaemia 13. Yeast as a Model Organism for Studying Apoptosis 14. Regulation of Programmed Cell Death and Viral Pathogenesis by the BCL-2 Protein Family and Caspases 15. Death Paradigms in Cellular Hypoxia