Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms: 4th Edition (Hardback) book cover

Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms

4th Edition

Edited by Linda A. Felton

CRC Press

400 pages | 16 Color Illus. | 299 B/W Illus.

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Hardback: 9781498732086
pub: 2016-10-13
eBook (VitalSource) : 9781315369938
pub: 2016-09-19
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Aqueous-based film coating has become routine in the pharmaceutical industry. This process eliminates the use of organic solvents and thus avoids economic, environmental, and toxicological issues related to residual solvents and solvent recovery. Aqueous-based coating, however, is complex and many variables may impact the final product and its performance. This fourth edition of Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms aims to provide insight into the factors and parameters that should be considered and controlled for the successful development and commercialization of a coated product.

The fourth edition has been revised and expanded to reflect the most recent scientific advancements from the literature. The contributing authors explain in detail, using illustrated examples, appropriate steps to solve and ideally avoid formulation, processing, and stability problems and to achieve an optimized dosage form. Trade names and chemical names of commercially marketed coatings are used throughout the text to help familiarize the reader with the various materials available for pharmaceutical applications. This book will be a valuable resource for anyone in the pharmaceutical industry working in the area of aqueous-based film coating.

Table of Contents

Aqueous-based polymeric coating. Pseudolatex dispersions for controlled drug delivery. Processing and equipment considerations for aqueous-based coatings. Mechanical properties of polymeric films prepared from aqueous dispersions. Defects in aqueous film coated solid oral dosage form. Adhesion of polymeric films. Influence of insoluble additives on the properties of polymeric coating systems. Process and formulation factors affecting drug release from pellets coated with ethylcellulose pseudolatex Aquacoat. Chemistry and application properties of polymethacrylate systems. Application of HPMC and HPMCAS to aqueous film coating of pharmaceutical dosage forms. The applications of formulated systems for aqueous film coating of pharmaceutical solid oral dosage forms. *Substrate considerations when developing an aqueous film coated solid oral dosage form. Polymer interactions with drugs and excipients. Physical aging of polymers and it effect on the stability of solid oral dosage forms.

About the Series

Drugs and the Pharmaceutical Sciences

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology
TECHNOLOGY & ENGINEERING / Textiles & Polymers