Articular Cartilage (Hardback) book cover

Articular Cartilage

By Kyriacos A. Athanasiou, Eric M. Darling, Jerry C. Hu, Grayson D. DuRaine, A. Hari Reddi

© 2013 – CRC Press

439 pages | 32 Color Illus. | 66 B/W Illus.

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Paperback: 9781138073111
pub: 2017-03-29
Hardback: 9781439853245
pub: 2013-03-21
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Well-known for their inability to heal, articular cartilage injuries often degenerate inexorably to disastrous impairment. Multitudes of treatments have been devised for this problem, but no satisfactory long-term solutions have been established. Written by world-class experts, Articular Cartilage covers the latest research and advancements related to biology, development, pathology, clinical applications, and tissue engineering. This bookis useful for rheumatologists, orthopaedic surgeons, cartilage biologists, and cartilage engineers as well as for professionals working in the orthopaedic and other musculoskeletal industries. This book also belongs in the library of primary care physicians, gerontologists, physical therapists, kinesiologists, and chiropractors. Written at a level that allows accessibility to a wide audience, it provides an interdisciplinary approach that encompasses the breadth and depth of basic science, bioengineering, translational science, and detailed methodologic approaches.

The authors examine the major events and signaling molecules that lead to development of articular cartilage from precursor cells, and the changes in cartilage as it matures and ages. They focus on the epidemiology, etiopathogenesis, and therapeutic approaches for cartilage injury and the major arthritides that affect cartilage and the synovial joints such as osteoarthritis, rheumatoid arthritis, and gout. They supply an up-to-date overview of the field of tissue engineering as applied to articular cartilage repair. They examine a number of methods used to assess structure, composition, biology, and biomechanical function. Each chapter contains extensive references to enhance additional study.

The book’s comprehensive focus on multiple aspects of articular cartilage sets it apart from other tissue engineering or developmental biology-based books available. It includes important discussions and perspectives on many of the remaining challenges and opportunities in the development and translation of new approaches for treating diseases of articular cartilage. It also provides detailed working protocols for many of the methods used to study articular cartilage, coverage of current treatment options, and business and regulatory aspects of the development of cartilage products. It provides a deeper understanding that will help with the development of new products and clinical applications.


"By revealing the wealth of knowledge we have accumulated in this area, as well as exposing the tremendous opportunities for advancement, Articular Cartilage provides a critical template for those seeking to study one of the most complex tissues of the human body. Only through this level of understanding will we eventually be able to develop new methods to diagnose, prevent, or treat diseases of articular cartilage."

—From the Foreword by Farshid Guilak, Ph.D.,Laszlo Ormandy Professor of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA

"… this is an important contribution to the literature on the important tissue/issue cartilage that I can strongly recommend to everyone interested in cartilage – basic scientists as well as clinical doctors. …It covers up to date knowledge on cartilage (mainly hyaline articular cartilage) regarding morphology, biomechanics, development and tissue engineering. …Most of the chapters are full of interesting facts and presented in an easy to read style."

––International Cartilage Repair Society, Winter 2013

Table of Contents

Structure and Function of Cartilage


Chondrocytes and Their Cellular Characteristics

Cartilage Matrix Characteristics and Organization

Articular Cartilage Biomechanical Properties

Chapter Concepts


Articular Cartilage Development


Cellular Behavior during Embryogenesis

Articular Cartilage Growth and Maturation

Signaling Pathways during Development and Maintenance of Articular Cartilage

Signaling Factors

Chapter Concepts


Articular Cartilage Pathology and Therapies


Cartilage Injuries

Current and Emerging Therapies for Articular Cartilage Repair and Arthritis

Motivation for Tissue Engineering

Chapter Concepts



Tissue Engineering of Articular Cartilage


The Need for In Vitro Tissue Engineering

Cell Source

Biomaterials and Scaffold Design

Bioactive Molecules for Cartilage Engineering

Bioreactors and Mechanical Stimulation

Convergence of Stimuli

Chapter Concepts


Methods for Evaluating Articular Cartilage Quality


Imaging Techniques

Histology, Immunohistochemistry, and Other Ultrastructural Techniques

Techniques for the Quantitative Assessment of Biochemical Components

Biomechanical Techniques

Animal Models

Clinical Scoring Systems

Chapter Concepts


Perspectives on the Translational Aspects of Articular Cartilage Biology


Challenges and Opportunities in Articular Cartilage Biology and Regeneration

Immune Response, Immunogenicity, and Transplants

Business Aspects and Regulatory Affairs

Statutes and Guidelines

Chapter Concepts


Experimental Protocols


Tissue and Cell Culture

Gross Morphology, Histology, and Immunohistochemistry

Protein Analysis

Insoluble Matrix Component Extraction and Assaying

RNA Extraction and Gene Expression

Assaying Tissue Biomechanical Properties

Animal Protocols

About the Authors

Kyriacos A. Athanasiou is a Distinguished Professor and Chair Department of Biomedical Engineering at the University of California, Davis. Eric M. Darling is an Assistant Professor of Molecular Pharmacology, Physiology and Biotechnology at Brown University, Rhode Island. Jerry C. Hu is a Senior Research Scientist in the Department of Biomedical Engineering at the University of California, Davis.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biotechnology
MEDICAL / Clinical Medicine