Occupational factors are responsible for a large percentage of cases of asthma in adults of working age. Any irritant generated at high concentrations can cause occupational asthma, and early diagnosis is critical because cure is still possible at this stage. This latest edition of Asthma in the Workplace reflects the rapid pace of discovery and research in workplace asthma that has taken place in recent years.
This Fourth Edition retains the international flavor of prior editions, with contributions from editors and contributors from around the world. Several chapters commence with clinical histories and workplace scenarios relevant to the focus of the chapter, making it particularly germane for primary care providers to develop skills in early recognition of the disease.
Topics discussed include:
- Definitions, historical background, epidemiology, genetics, pathophysiology, and animal models
- Guidelines for assessing the worker and the workplace, and proposed guidelines for management, including compensation aspects
- Medicolegal aspects, prevention, and surveillance
- Detailed information about specific agents, including a variety of high- and low-molecular weight agents
- Other types of work-related asthma conditions, such as irritant-induced asthma, eosinophilic bronchitis, and occupational rhinitis
This new edition has been significantly restructured and places a greater emphasis on the clinical aspects of management and treatment. This heightened focus on practical considerations makes it a truly comprehensive, hands-on resource for practitioners and researchers in this fast-moving field.
Table of Contents
Definition and classification of asthma in the workplace; I. Leonard Bernstein, David I. Bernstein,
Moira Chan-Yeung, Jean-Luc Malo
Historical aspects; Jack Pepys, I. Leonard Bernstein, Jean-Luc Malo
Disease occurrence and risk factors; Maritta S. Jaakkola, Denyse Gautrin, Jean-Luc Malo
Mechanisms, genetics, and pathophysiology; Piero Maestrelli, Berran Yucesoy, Hae-Sim Park,
Animal models; Victor J. Johnson, Vanessa De Vooght, Jeroen A.J. Vanoirbeek
Assessment of the worker; André Cartier, Nathalie Bourdeau, Pierre Phénix, Kenneth D. Rosenman
Assessment of the workplace; Dick Heederik, Lygia Budnik, Brigitte Roberge, Nicole Goyer
Immunological and inflammatory assessments; Catherine Lemiere, David I. Bernstein, Leslie C. Grammer, Meinir Jones, Hae-Sim Park
Functional assessment; Olivier Vandenplas, P. Sherwood Burge, Gianna Moscato, Jean-Luc Malo
Management of the worker; André Cartier, Paul K. Henneberger, Stuart M. Brooks
Protecting the worker and modifying the work environment; Dick Heederik, Remko Houba, Gary M. Liss,
Prevention and surveillance; Gary M. Liss, Susan M. Tarlo, Manon Labrecque, Jean-Luc Malo
Impairment and disability evaluations: I. Psychosocial, economic, and medicolegal aspects; Paul D. Blanc, Philip Harber, Kim L. Lavoie, Olivier Vandenplas
Impairment and disability evaluation: II. Various legislations; Mohamed F. Jeebhay, Philip Harber, Xaver Baur, Marcos Ribeiro, Hae-Sim Park, Jean-Luc Malo
Specific Agents Causing Immunological Occupational Asthma
High- and low-molecular weight agents; Moira Chan-Yeung, Jean-Luc Malo, David I. Bernstein
Enzymes; Jonathan A. Bernstein, Katherine Sarlo, Carlos Rodriguez, Remko Houba
Occupational asthma in the baking industry; Paul Cullinan, Torben Sigsgaard, Rolf Merget
Asthma and allergy to animals; Karin A. Pacheco, Denyse Gautrin, Andreas L. Lopata, Mohamed F. Jeebhay
Polyisocyanates and their prepolymers; Adam V. Wisnewski, Carrie A. Redlich, Cristina E. Mapp, David I. Bernstein
Western red cedar and other wood dusts; Moira Chan-Yeung, Jean-Luc Malo, Torben Sigsgaard
Metals; Rolf Merget, Denyse Gautrin
Specific Disease Entities and Variants
Irritant-induced asthma and reactive airways dysfunction syndrome; Stuart M. Brooks, Jean-Luc Malo, Denyse Gautrin
Asthma exacerbated at work; Paul K. Henneberger, Gregory R. Wagner, Catherine Lemière
Eosinophilic bronchitis; Santiago Quirce, Catherine Lemière, Joaquín Sastre
Occupational rhinitis; Gianna Moscato, Mark S. Dykewicz, Martin Desrosiers, Roberto Castano
Airway diseases due to organic dust exposure; Moira Chan-Yeung, I. Leonard Bernstein, Susanna Von Essen, Jill A. Poole
Chronic obstructive airway disease due to occupational exposure; Paul D. Blanc, Eva Hnizdo,
Kathleen Kreiss, Kjell Toren
Hypersensitivity pneumonitis and organic dust toxic syndrome; Yvon Cormier, Yves Lacasse
Building-related illnesses and mold-related conditions; Dan Norbäck, J. David Miller
Occupational urticaria and allergic contact dermatitis; D. Linn Holness, Victoria H. Arrandale, C.G. Toby Mathias
Jean-Luc Malo, M.D. is Professor of Respiratory Medicine and former Vice-Dean at the Faculty of Medicine of Université de Montréal. He practices as a chest physician at Sacré-Coeur Hospital in Montreal. During his career, he has been principally involved in the improvement of diagnostic means of occupational asthma and has identified many causal agents. He has described the outcome after cessation of exposure in the case of immunological and non-immunological occupational asthma and participated in epidemiological studies of apprentices and workers. Dr. Malo has contributed to international research projects, position papers and guidelines in the field of asthma in the workplace.
Moira Chan-Yeung, MB, FRCPC is Emeritus Professor, Department of Medicine, at the University of British Columbia, Vancouver, in Canada. She is the recipient of the Alice Hamilton Award for Major and Lasting Contribution in Occupational Health from the American Industrial Hygiene Association and the prestigious Distinguished Achievement award from the American Thoracic Society, among other honours. One of her many noteworthy contributions is her discovery of plicatic acid as the agent responsible for Western Red Cedar asthma. Since Dr. Chan-Yeung began her research in the Department of Medicine in 1968, she has published over 370 peer-reviewed articles and 5 books and has a research laboratory dedicated to her work in UBC.
David I Bernstein, M.D. is Professor of Medicine and Environmental Health at the University of Cincinnati Division of Immunology, Allergy, and Rheumatology. He has been Director or Co-Director of the Allergy Immunology fellowship training program at the University of Cincinnati for 30 years. During his career, he has focused his research efforts on the investigation of occupational asthma and environmental causes of allergic disorders in childhood. Dr. Bernstein has contributed to developing methods for immunologic evaluation of occupational asthma, and more recently, to better understanding genetic determinants of occupational asthma. He has authored or co-authored 157 articles in peer-reviewed journals as well numerous reviews and book chapters.