3rd Edition

Atlas of Differential Diagnosis in Neoplastic Hematopathology

ISBN 9781482212211
Published March 21, 2014 by CRC Press
920 Pages 900 Color Illustrations

USD $350.00

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Book Description

Management of tumor patients now relies on new individualized approaches to treatment, requiring extensive knowledge of the molecular makeup of tumors. Updated and expanded, the third edition of Atlas of Differential Diagnosis in Neoplastic Hematopathology examines not only the differential diagnosis but also the detailed morphologic, immunophenotypic, and especially genetic characteristics of the majority of hematolymphoid malignancies.

Featuring a new structure and including new chapters, the third edition updates all content and presents considerable expansion on many topics, including:

  • Metaphase cytogenetic and FISH
  • Flow cytometry (overview and detailed analysis of specific tumors)
  • Acute myeloid leukemia and new classification schemes
  • MDS, AML, and B- and T-cell lymphoproliferations
  • Abnormal patterns in the lymph node and bone marrow with detail differential diagnosis based on histologic features and cellular composition
  • Detailed differential diagnosis based on the expression of broad list of antigenic markers (flow cytometry and immunohistochemistry)
  • Extranodal lymphomas
  • Diagnosis of MDS and myeloproliferative neoplasm and their differential diagnosis based on the morphologic, flow cytometric, and chromosomal features

The book also provides expanded differential diagnosis of the most common as well as most difficult and rare entities, including morphologic, immunophenotypic, and karyotypic/molecular features. This edition includes updated algorithms for most common diagnoses as well as several new algorithms. The majority of figures have been revised and are in full color.



Table of Contents

General Histologic and Cytologic Features

Lymph Node

Bone Marrow


Flow Cytometry


Immunophenotypic Markers: Differential Diagnosis

Introduction to Cytogenetics, FISH, and Molecular Testing


Fluorescence In-Situ Hybridization and Polymerase Chain Reaction

Mature B-Cell Neoplasms

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and B-Cell Prolymphocytic Leukemia

Mantle Cell Lymphoma

Marginal Zone Lymphoma

Follicular Lymphoma

Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia

Diffuse Large B-Cell Lymphoma and its Variants

Hairy Cell Leukemia

Burkitt Lymphoma and B-Cell Lymphoma, Unclassifiable (with Features Intermediate between Burkitt Lymphoma and DLBCL)

Plasma Cell Neoplasms

B-Cell Lymphomas with Plasmablastic Morphology and/or EBV Expression

Mature T-Cell Neoplasms

Adult T-Cell Leukemia/Lymphoma

T-Cell Prolymphocytic Leukemia and T-Cell Large Granular Lymphocyte Leukemia

Peripheral T-Cell Lymphoma

Angioimmunoblastic T-Cell Lymphoma

Anaplastic Large Cell Lymphoma

Extranodal Natural Killer/T- Cell Lymphoma, Nasal Type

Hodgkin Lymphoma

Classical Hodgkin Lymphoma

Nodular Lymphocyte Predominant Hodgkin Lymphoma

Myeloproliferative Neoplasms

Introduction to Myeloproliferative Neoplasms

Chronic Myeloid Leukemia

Polycythemia Vera

Essential Thrombocythemia

Primary Myelofibrosis

Other Myeloproliferative Neoplasms

Myelodysplastic Syndromes and Mixed Myelodysplastic/ Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Mixed Myelodysplastic–Myeloproliferative Neoplasms

Acute Myeloid Leukemia

Acute Myeloid Leukemia: Introduction

Acute Myeloid Leukemia without Specific Genetic Changes

Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

Acute Lymphoblastic Leukemia and Other Hematopoietic Tumors

B-Lymphoblastic Leukemia/Lymphoma

T-Lymphoblastic Leukemia/Lymphoma

Other Tumors

Extranodal Lymphomas and their Differential Diagnosis

Body Cavities


Lung and Mediastinum

Salivary Glands



Stomach and Gastrointestinal Tract




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Wojciech Gorczyca is a noted authority in clinical flow cytometry and hematopathology. He served for more than ten years as a hematopathologist and director of hematopathology with Genzyme Genetics, Inc. / IMPATH, Inc. and later with CSI Laboratories’ medical team where he worked as director of flow cytometry. Currently he works at Bioreference Laboratories in New Jersey where he also serves as hematopathologist for Regional Cancer Care Associates in Hackensack. He earned his medical degree and doctorate in pathology from Pomeranian Medical University in Szczecin, Poland. Dr. Gorczyca completed fellowships in flow cytometry at Radium Hospital in Oslo, Norway and at New York Medical College in Valhalla, New York. A well-respected lecturer and author, he has published numerous peer-reviewed journal articles and six textbooks including Flow Cytometry in Neoplastic Hematology: Morphologic-Immunophenotypic Correlation, 2nd edition and Atlas of Differential Diagnosis in Neoplastic Hematopathology, 2nd edition.

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