This volume reviews the current state of research within the behavioral pharmacology of 5-HT. The book opens exciting new approaches to the interdisciplinary study of behavior and pharmacology with special reference to ethology, endocrinology, neuroanatomy and comparative aspects of drug action, and notes new developments in therapeutic drugs of the future.
Contents: Section I: A.R. Cools, Introduction. A.R. Green, Behavioural Pharmacology of 5-HT: An Introduction. T.P. Blackburn, D.A. Martin, P. Slater, Is Rotational Behaviour in the Rat a 5-HT1A or 5-HT1B Mediated Response? A.J. Stoessl, C.T. Dourish, S.D. Iversen, Serotonic Mediated Behaviour Following Central or Peripheral Administration of the Selective NK-3 Tachykinin Agonist Senktide. Section II: P. Bevan, 5-HT and Sexual Behavior. S. Ahlenius, K. Larsson, New Aspects on the Serotonergic Modulation of Male Rat Sexual Behaviour. S.D. Mendelson, B.B. Gorzalka, Differential Roles of 5-HT Receptor Subtypes in Female Sexual Behaviour. M.D. James, S.M. Lane, D.R. Hole, C.A. Wilson, Hypothalamic Sites of Action of the Dual Effect of 5-HT on Female Sexual Behaviour in the Rat. L. R nyi, T. Lewander, 5-HT1A and 5-HT1B Agonists Produce Opposite Effects on the Ejaculatory Response Induced by Amphetamine in Rats. H.H.G. Berendsen, R.J.M. Smets, C.L.E. Broekkamp, Functional Interplay of Serotonin(5-HT)-Receptor Subtypes. Section III: P. Bevan, 5-HT and Aggression. B. Olivier, J. Mos, M. Tulp, J. Schipper, P. Bevan, Modulatory Action of Serotonin in Aggressive Behaviour. K.A. Miczek, P. Donat, Brain 5-HT System and Inhibition of Aggressive Behaviour. D.C. Blanchard, K. Hori, R.J. Rodgers, C.A. Hendrie, R.J. Blanchard, Differential Effects of Benzodiazepines and 5-HT1A Agonists on Defensive Patterns in Wild Rattus. C. Gentsch, M. Lichtsteiner, H. Feer, Competition for Sucrose-Pellets in Triads of Male, Wistar Rats, the Effects of Eight 5-HT- Agonists. Section IV: A.R. Cools, Depression and Psychosis. P. Willner, Towards a Theory of Serotonergic Dysfunction in Depression. J.F.W. Deakin, 5-HT Receptor Subtypes in Depression. J.A.M. van der Heyden, Modulation of the 5-HT System and Antipsychotic Activity. G.A. Kennet, G. Curzon, Mechanism of Action of 8-OH-DPAT on a Rat Model for Human Depression. P. Martin, A.M. Laporte, P. Soubrie, E. El Mestikawy, M. Hamon, Reversal of Helpless Behaviour in Rats by Serotonin Uptake Inhibitors. T.F. Meert, C.J.E. Niemegeers, Y.G. Gelders, P.A.J. Janssen, Ritanserin (R 55 667), an Original Thymosthenic. N.M. Barnes, B. Costall, A.M. Domeney, M.E. Kelly, R.J. Naylor, M.B. Tyers, The Abilities of 5-HT3 Antagonists to Inhibit the Hyperreactivity Caused by Dopamine Infusion into the Nucleus Accumbens of the Rat. M.A. Geyer, 5-HT2 Antagonists Increase Tactile Startle Habituation in an Animal Model of a Habituation Deficit in Schizophrenia. Section V: A.R. Cools, Feeding Behaviour. E. Goodall, T. Silverstone, Pharmacological Evidence for the Involvement of Serotonergic Mechanisms in Human Feeding. R. Samanin, Serotonin and Feeding. P.H. Hutson, G.A. Kennett, T.P. Donohoe, C.T. Dourish, G. Curzon, Opposite Effects of 5-HT1A and 5-HT1B/1C agonists on Food Intake. J.D. Leander, Effects of Selective Serotonergic Agonists on Palatability-Induced Ingestion. A.M.J. Montgomery, P. Willner, R. Muscat, 8-OH-DPAT Reliably Increases Ingestion of Solid but not Liquid Diets. C.L. Lawton, J.E. Blundell, Pharmacological Manipulation of 5-HT: Effect on Intake of Diets Supplemented with Either Sweet or Bland Carbohydrates. Section VI: T. Archer, 5-HT, Pain and Anxiety. O-G. Berge, C. Post, T. Archer, The Behavioural Pharmacology of Serotonin in Pain Processes. C.L. Broekkamp, F. Jenck, The Relationship Between Various Animal Models of Anxiety, Fear-Related Psychiatric Symptoms and Response to Serotonergic Drugs. P. Soubrie, 5-HT1A Receptors: A Bridge Between Anxiety and Depression? M.B. Tyers, A Review of the Evidence Supporting the Anxiolytic Potential of 5-HT3 Receptor Antagonists. J. Mos, B. Olivier, Ultrasonic Vocalizations by Rat Pups as an Animal Model for Anxiolytic Activity: Effects of Serotonergic Drugs. S.A. Lorens, H. Mitsushio, L.D. Van der Kar, Effects of the 5-HT1A Agonist Ipsapirone on the Behavioural, Endocrine and Neurochemical Responses to Conditioned Fear. P. Moser, Buspirone, Ipsapirone and 5-HT1A-Receptor Agonists Show an Anxiogenic-Like Profile in the Elevated Plus-Maze. A. Fernandez-Guasti, E. Hong, Antianxiety Effect of Various Putative 5-HT1 Receptor Agonists on the Conditioned Defensive Burying Paradigm. B.Costall, A.M. Domeney, P.A. Gerrard, B.J. Jones, M.E. Kelly, N.R. Oakley, M.B. Tyers, The Anxiolytic Activities of the 5-HT3 Receptor Antagonists GR38032F, ICS 205-930 and BRL 43694. J. Mos, J.A.M. van der Heyden, B. Olivier, Behavioural Effects of 5-HT3 Antagonists in Animal Models for Aggression, Anxiety and Psychosis. Section VII: T.U.C. Jarbe, T.Archer, 5-HT: Drug Discrimination and Aversion. W. Koek, F.C. Colpaert, Receptor Mechanisms of the Discriminative Stimulus Properties of Putative Serotonin Agonists. F.G. Graeff, Serotonin and Aversion. R.A. Glennon, R. Young, M.E. Pierson, Stimulus Properties of Arylpiperazine Second Generation Anxiolytics. J.E. Barrett, S.N. Olmstead, Z. Lei, C. Harrod, S.M. Hoffmann, K. Glover, M.A. Nader, B.A. Weissman, Behavioural, Neurochemical and Discriminative Stimulus Effects of Spiroxatrine, a Putative 5-HT1A Receptor Antagonist. I. Lucki, J.A. South, Rapid Training of the Stimulus Properties of Selective 5-Hydroxtryptamine1A Agonists. Section VIII: P. Bevan, S. Lorens, T. Archer, Behavioural Pharmacology of 5-HT: Possible Progress in the Laterality of Concepts.