Big Data Analysis for Bioinformatics and Biomedical Discoveries: 1st Edition (Hardback) book cover

Big Data Analysis for Bioinformatics and Biomedical Discoveries

1st Edition

Edited by Shui Qing Ye

Chapman and Hall/CRC

274 pages | 23 B/W Illus.

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pub: 2015-12-22
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Demystifies Biomedical and Biological Big Data Analyses

Big Data Analysis for Bioinformatics and Biomedical Discoveries provides a practical guide to the nuts and bolts of Big Data, enabling you to quickly and effectively harness the power of Big Data to make groundbreaking biological discoveries, carry out translational medical research, and implement personalized genomic medicine. Contributing to the NIH Big Data to Knowledge (BD2K) initiative, the book enhances your computational and quantitative skills so that you can exploit the Big Data being generated in the current omics era.

The book explores many significant topics of Big Data analyses in an easily understandable format. It describes popular tools and software for Big Data analyses and explains next-generation DNA sequencing data analyses. It also discusses comprehensive Big Data analyses of several major areas, including the integration of omics data, pharmacogenomics, electronic health record data, and drug discovery.

Accessible to biologists, biomedical scientists, bioinformaticians, and computer data analysts, the book keeps complex mathematical deductions and jargon to a minimum. Each chapter includes a theoretical introduction, example applications, data analysis principles, step-by-step tutorials, and authoritative references.

Table of Contents

Commonly Used Tools for Big Data Analysis

Linux for Big Data Analysis

Shui Qing Ye and Ding-You Li

Python for Big Data Analysis

Dmitry N. Grigoryev

R for Big Data Analysis

Stephen D. Simon

Next-Generation DNA Sequencing Data Analysis

Genome-Seq Data Analysis

Min Xiong, Li Qin Zhang, and Shui Qing Ye

RNA-Seq Data Analysis

Li Qin Zhang, Min Xiong, Daniel P. Heruth, and Shui Qing Ye

Microbiome-Seq Data Analysis

Daniel P. Heruth, Min Xiong, and Xun Jiang

miRNA-Seq Data Analysis

Daniel P. Heruth, Min Xiong, and Guang-Liang Bi

Methylome-Seq Data Analysis

Chengpeng Bi

ChIP-Seq Data Analysis

Shui Qing Ye, Li Qin Zhang, and Jiancheng Tu

Integrative and Comprehensive Big Data Analysis

Integrating Omics Data in Big Data Analysis

Li Qin Zhang, Daniel P. Heruth, and Shui Qing Ye

Pharmacogenetics and Genomics

Andrea Gaedigk, Katrin Sangkuhl, and Larisa H. Cavallari

Exploring De-Identified Electronic Health Record Data with i2b2

Mark Hoffman

Big Data and Drug Discovery

Gerald J. Wyckoff and D. Andrew Skaff

Literature-Based Knowledge Discovery

Hongfang Liu and Majid Rastegar-Mojarad

Mitigating High Dimensionality in Big Data Analysis

Deendayal Dinakarpandian

About the Editor

Shui Qing Ye, MD, PhD, is the William R. Brown/Missouri Endowed Chair in Medical Genetics and Molecular Medicine and a tenured full professor in biomedical and health informatics and pediatrics at the University of Missouri–Kansas City School of Medicine. He is also the director of the Division of Experimental and Translational Genetics in the Department of Pediatrics and director of the Core of Omics Research at The Children’s Mercy Hospital. Dr. Ye has been involved with biomedical research for more than 30 years. His current research interests include the application of translational bioinformatics to leverage Big Data to make biological discoveries and gain new, unifying global biological insights, which may lead to the development of new diagnostic and therapeutic targets for human diseases.

About the Series

Chapman & Hall/CRC Mathematical and Computational Biology

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Subject Categories

BISAC Subject Codes/Headings:
MATHEMATICS / Probability & Statistics / General
SCIENCE / Life Sciences / Biology / General
SCIENCE / Biotechnology