Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches, and Development, 1st Edition (Hardback) book cover

Bioadhesive Drug Delivery Systems

Fundamentals, Novel Approaches, and Development, 1st Edition

Edited by Edith Mathiowitz, Donald E. Chickering III, Claus-Michael Lehr

CRC Press

696 pages

Purchasing Options:$ = USD
Hardback: 9780824719951
pub: 1999-07-13

FREE Standard Shipping!


This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs.

Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport!

Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems

  • discusses mechanical and chemical bonding, polymer-mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology

  • analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces

  • covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions

  • examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles

  • describes vaginal, nasal, buccal, ocular, and transdermal drug delivery

  • reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts

  • explores issues of product development, clinical testing, and production

  • and more!

    Amply referenced with over 1400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologists; chemical, polymer, and plastics engineers; biochemists; physical, surface, and colloid chemists; biologists; and upper-level undergraduate and graduate students in these disciplines.

  • Reviews


    This comprehensive, multi-author volume would form an excellent starting point for researchers, students and industrial scientists keen to familiarize themselves with this field.

    …This book, a welcome addition to the series 'Drugs and the Pharmaceutical Sciences', will provide excellent background and, indeed, might almost be regarded as a manual for those working in this areas.

    "- Retinoids & Lipid-Soluable Vitamins in Clinical Practice


    …very interesting and certainly stimulating. The authors and the editors are to be congratulated for providing a valuable and timely review of a new development subject.

    "-Pharmaceutical Technology

    Table of Contents

    Fundamentals of Bioadhesion

    Definitions, Mechanisms, and Theories of Bioadhesion

    Donald E. Chickering III and Edith Mathiowitz

    The Role of Water Movement and Polymer Hydration in Mucoadhesion

    John D. Smart

    A Rheological Approach to Explain the Mucoadhesive Behavior of Polymer Hydrogels

    Carla Marcella Caramella, Silvia Rossi, and Maria Cristina Bonferoni

    Functional Histology of Epithelia Relevant for Drug Delivery: Respiratory Tract, Digestive Tract, Eye, Skin, and Vagina

    Udo Schumacher and Dietlind Schumacher

    Biochemical and Functional Aspects of Mucus and Mucin-Type Glycoproteins

    Barry James Campbell

    Methods of Evaluating Bioadhesive Interactions

    Adaptation of a Microbalance to Measure Bioadhesive Properties of Microspheres

    Donald E. Chickering III, Camilla A. Santos, and Edith Mathiowitz

    Novel Magnetic Technique to Measure Bioadhesion

    Benjamin A. Hertzog and Edith Mathiowitz

    Principles of Skin Adhesion and Methods for Measuring Adhesion of Transdermal Systems

    Michael Horstmann, Walter Müller, and Bodo Asmussen

    Force Microscopy of Cells to Measure Bioadhesion

    E. zur Mühlen, P. Koschinski, S. Gehring, Robert Ros, Louis Tiefenhauer, Eleonore Haltner, Claus-Michael Lehr, Uwe Hartmann, Falk Schwesinger, and A. Plückthun

    Direct Measurement of Molecular-Level Forces and Adhesion in Biological Systems

    James Schneider and Matthew Tirrell

    A Centrifugation Method for Measurement of Two-Dimensional Binding Characteristics of Receptor-Ligand Interaction

    Cheng Zhu, James W. Piper, and Robert A. Swerlick

    Novel Concepts and Strategies for Bioadhesive Drug Delivery Systems

    Multifunctional Polymers for the Peroral Delivery of Peptide Drugs

    Henrik L. Luessen, J. Coos Verhoef, A. (Bert) G. de Boer, H. E. Junginger, Bas J. de Leeuw, Gerrit Borchard, and Claus-Michael Lehr

    Chitosan and Chitosan Derivatives as Absorption Enhancers for Peptide Drugs Across Mucosal Epithelia

    A. F. Kotzé, Henrik L. Luessen, M. Thanou, J. Coos Verhoef, A. (Bert) G. de Boer, H. E. Junginger, and Claus-Michael Lehr

    Plant Lectins for Oral Drug Delivery to Different Parts of the Gastrointestinal Tract

    Arpad Pusztai, Susan Bardocz, and Stanley W. B. Ewen

    Bacterial Invasion Factors and Lectins as Second-Generation Bioadhesives

    James H. Easson, Eleonore Haltner, Claus-Michael Lehr, and Dieter Jahn

    Novel PEG-Containing Acrylate Copolymers with Improved Mucoadhesive Properties

    Amir H. Shojaei and Xiaoling Li

    Bioadhesive, Bioerodible Polymers for Increased Intestinal Uptake

    Gerardo P. Carino, Jules S. Jacob, C. James Chen, Camilla A. Santos, Benjamin A. Hertzog, and Edith Mathiowitz

    Development Issues of Bioadhesive Drug Delivery Systems: Products and Clinical Trials

    Novel Formulation Approaches to Oral Mucoadhesive Drug Delivery Systems

    Yohko Akiyama and Naoki Nagahara

    Bioadhesive Formulations for Nasal Peptide Delivery

    Lisbeth Illum

    Development of Bioadhesive Buccal Patches

    Jian-Hwa Guo and Karsten Cremer

    Vaginal Delivery of Calcitonin by Hyaluronic Acid Formulations

    Julie L. Richardson and Trevor I. Armstrong

    Ocular Bioadhesive Drug Delivery Systems

    Marco Fabrizio Saettone, Susi Burgalassi, and Patrizia Chetoni

    Bioadhesive Preparations as Topical Dosage Forms

    Yoshiharu Machida and Tsuneji Nagai

    About the Editors

    Edith Mathiowitz, Donald E. Chickerin III, Claus-Michael Lehr

    About the Series

    Drugs and the Pharmaceutical Sciences

    Learn more…

    Subject Categories

    BISAC Subject Codes/Headings:
    MEDICAL / Pharmacology
    MEDICAL / Pharmacy