1st Edition

Bioadhesive Drug Delivery Systems
Fundamentals, Novel Approaches, and Development




ISBN 9780824719951
Published July 13, 1999 by CRC Press
696 Pages

USD $240.00

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Book Description

This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs.
Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport!
Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems

  • discusses mechanical and chemical bonding, polymer-mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology
  • analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces
  • covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions
  • examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles
  • describes vaginal, nasal, buccal, ocular, and transdermal drug delivery
  • reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts
  • explores issues of product development, clinical testing, and production
  • and more!
    Amply referenced with over 1400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologist

  • Table of Contents

    Fundamentals of Bioadhesion
    Definitions, Mechanisms, and Theories of Bioadhesion
    Donald E. Chickering III and Edith Mathiowitz
    The Role of Water Movement and Polymer Hydration in Mucoadhesion
    John D. Smart
    A Rheological Approach to Explain the Mucoadhesive Behavior of Polymer Hydrogels
    Carla Marcella Caramella, Silvia Rossi, and Maria Cristina Bonferoni
    Functional Histology of Epithelia Relevant for Drug Delivery: Respiratory Tract, Digestive Tract, Eye, Skin, and Vagina
    Udo Schumacher and Dietlind Schumacher
    Biochemical and Functional Aspects of Mucus and Mucin-Type Glycoproteins
    Barry James Campbell
    Methods of Evaluating Bioadhesive Interactions
    Adaptation of a Microbalance to Measure Bioadhesive Properties of Microspheres
    Donald E. Chickering III, Camilla A. Santos, and Edith Mathiowitz
    Novel Magnetic Technique to Measure Bioadhesion
    Benjamin A. Hertzog and Edith Mathiowitz
    Principles of Skin Adhesion and Methods for Measuring Adhesion of Transdermal Systems
    Michael Horstmann, Walter Müller, and Bodo Asmussen
    Force Microscopy of Cells to Measure Bioadhesion
    E. zur Mühlen, P. Koschinski, S. Gehring, Robert Ros, Louis Tiefenhauer, Eleonore Haltner, Claus-Michael Lehr, Uwe Hartmann, Falk Schwesinger, and A. Plückthun
    Direct Measurement of Molecular-Level Forces and Adhesion in Biological Systems
    James Schneider and Matthew Tirrell
    A Centrifugation Method for Measurement of Two-Dimensional Binding Characteristics of Receptor-Ligand Interaction
    Cheng Zhu, James W. Piper, and Robert A. Swerlick
    Novel Concepts and Strategies for Bioadhesive Drug Delivery Systems
    Multifunctional Polymers for the Peroral Delivery of Peptide Drugs
    Henrik L. Luessen, J. Coos Verhoef, A. (Bert) G. de Boer, H. E. Junginger, Bas J. de Leeuw, Gerrit Borchard, and Claus-Michael Lehr
    Chitosan and Chitosan Derivatives as Absorption Enhancers for Peptide Drugs Across Mucosal Epithelia
    A. F. Kotzé, Henrik L. Luessen,

    ...
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    Editor(s)

    Biography

    Edith Mathiowitz, Donald E. Chickerin III, Claus-Michael Lehr