Animal models are critical to advancing the understanding of and intervention in human disease in almost all areas of the life sciences. This volume provides examples of how animal experimentation leads to data applicable to human disease. The ethics of animal use is explored, and details of the advantages of animal models over alternate systems are presented. The text guides the thought processes of students and scientists as they evaluate the potential use of animals in their own biomedical research.
Table of Contents
Animal models - goals and problems; transgenic animal models of disease; murine models of genetic abnormalities - of mice and man-made mice; animal models in genetic therapy; the biological basis of the neurobehavioural features in Lesch-Nyhan disease - contributions from animal models; animal models of human central nervous system diseases - multiple sclerosis and amyotrophic lateral sclerosis; transgenic animal models in hypertension; models of skin diseases; bony diseases; AIDS models; comparative physiology of mammalian reproductive systems - limitations for disease models; ethics of animal use in experimentation.
Philip M. Iannaccone (Children's Memorial Hospital, Chicago, IL)