Biomaterials Science: An Integrated Clinical and Engineering Approach, 1st Edition (Hardback) book cover

Biomaterials Science

An Integrated Clinical and Engineering Approach, 1st Edition

Edited by Yitzhak Rosen, Noel Elman

CRC Press

330 pages | 66 B/W Illus.

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pub: 2012-06-06
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Description

"This book is essential when designing, developing and studying biomedical materials.… provides an excellent review—from a patient, disease, and even genetic point of view—of materials engineering for the biomedical field. … This well presented book strongly insists on how the materials can influence patients’ needs, the ultimate drive for biomedical engineering. …[presents an] Interesting and innovative review from a patient focus perspective—the book emphasizes the importance of the patients, which is not often covered in other biomedical material’s books."

Fanny Raisin-Dadre, BioInteractions Ltd., Berkshire, England

Going far beyond the coverage in most standard books on the subject, Biomaterials Science: An Integrated Clinical and Engineering Approach offers a solid overview of the use of biomaterials in medical devices, drug delivery, and tissue engineering.

Combining discussion of materials science and engineering perspectives with clinical aspects, this book emphasizes integration of clinical and engineering approaches. In particular, it explores various applications of biomaterials in fields including tissue engineering, neurosurgery, hemocompatibility, BioMEMS, nanoparticle-based drug delivery, dental implants, and obstetrics/gynecology.

The book engages those engineers and physicians who are applying biomaterials at various levels to:

  • Increase the rate of successful deployment of biomaterials in humans
  • Lower the side-effects of such a deployment in humans
  • Accumulate knowledge and experience for improving current methodologies
  • Incorporate information and understanding relevant to future challenges, such as permanent artificial organ transplants

Using a variety of contributors from both the clinical and engineering sides of the fields mentioned above, this book stands apart by emphasizing a need for the often lacking approach that integrates these two equally important aspects.

Reviews

"The book, written from well-known engineers and physicians expert in the field of the biomedical science, provides a clear picture of the innovative engineered materials used up today without forgetting the patient's needs. Thus it may be considered an important key stone for all physicians and chemical engineers involved in this fascinating field of engineered-medicine."

—Journal of Applied Cosmetology January/June 2013

"… offers a good overview of biomaterials as medical devices, drug delivery and tissue engineering systems. The emphasis is on integrating clinical and engineering approaches. In particular, the book covers various applications of biomaterials in unmet clinical needs in variety of fields … covers areas such as regulatory challenges and commercialization issues."

—From the Foreword by Robert Langer, Massachusetts Institute of Technology, Boston, USA

"This book is essential when designing, developing and studying biomedical materials.… provides an excellent review—from a patient, disease, and even genetic point of view—of materials engineering for the biomedical field. I found very interesting facts about patient study combined with clinical study of materials. This well presented book strongly insists on how the materials can influence patients’ needs, the ultimate drive for biomedical engineering.

"Bring[s] a new … very strong focus [on the] clinical point of view…[offers] a very interesting insight into biomedical engineering, where clinicians and engineers have to understand each other to provide specific solutions to the medical device field…[presents an] Interesting and innovative review from a patient focus perspective—the book emphasizes the importance of the patients, which is not often covered in other biomedical material’s books."

—Fanny Raisin-Dadre, BioInteractions Ltd., Berkshire, England

"The success of current and emerging biomedical technologies centers on multiple factors including device design, host foreign body reaction to the biomaterial, regulatory reviews, market needs, and patient-centered factors such as co-morbidity and underlying pathologies. The later point needs to be further emphasized in biomaterial education and training. This book highlights these critical elements in carefully selected case studies that are relevant and up to date. The advancement of biomaterials and medical devices require a multidisciplinary team approach including clinical insights. Drs. Rosen, Elman, and Horowitz effectively brought these interwoven topics together in this well presented reference book."

W. John Kao, University of Wisconsin – Madison, USA

Table of Contents

Introduction

Y. Rosen, N. Elman, E. Horowitz

Principles of Clinical and Engineering Integration in Hemocompatibility

Y. Rosen, N. Elman

Medical Applications of Micro-Electro-Mechanical Systems (MEMS) Technology

M.A. Huff

Nanoparticles to Cross Biological Barriers

T. Moore, E. Graham, B. Mattix, and F. Alexis

Biomaterials, Dental Materials, and Device Retrieval and Analysis

J.E. Lemons

Biomaterials and the Central Nervous System: Neurosurgical Applications of Materials Science

U.M. Upadhyay

Biomaterials in Obstetrics and Gynecology

D. Shveiky and Y. Hants

Tissue Engineering: Focus on the Cardiovascular System

A. Lesman, S. Levenberg

Tissue Engineering: Focus on the Musculoskeletal System

M. Keeney, L.-H. Han, S. Onyiah, F. Yang

Regulatory Challenges in Biomaterials: Focus on Medical Devices

P. Gurman, O. Rabinovitz-Harison, T.B. Hunter

Innovative Product Development and Technology Adoption for Medical Applications

S.M. Jarrett

Appendix: Some Examples of FDA-Approved Products

P. Gurman

About the Editors

Yitzhak Rosen, MD, is a graduate of the Tel Aviv University of Medicine. He is currently a visiting research scientist at the Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology. He is also the president and CEO of Superior NanoBioSystems LLC, a biomedical company. He has served in the Israel Defense Forces (IDF) as a medical officer and physician in militarily active areas. He completed a medical internship at the Rabin Medical Center and has worked at the Oncology Institutes of both the Rabin and the Sheba Medical Centers in Israel. He has invented a microfluidic chip platform, funded by the Defense Advanced Research Projects Agency (DARPA), for effecting extremely rapid blood typing and cross-matching for mass casualties in collaboration with the MEMS and Nanotechnology Exchange. In addition, he is the inventor of several medical ultrasound technologies.

Noel Elman, Ph.D, is currently a research scientist at the Institute for Soldier Nanotechnologies at the Massachusetts Institute of Technology (MIT). He leads a translational research group focused on biomedical technologies based on nano- and microtechnologies for both diagnostics and therapeutics. He received his BS and Master’s degrees in Electrical Engineering from Cornell University, where he focused on the development of MEMS and MOEMS micro-(opto)-electromechanical systems. He received his PhD degree in Physical Electronics from the Department of Electrical Engineering at Tel Aviv University in 2006. He then pursued postdoctoral research work at the Department of Materials Science and Engineering working closely with Dr. M. J Cima, Dr. Robert Langer, and Dr. John Joannopoulos, combining and applying a multidisciplinary approach to create novel biomedical microdevices based on MEMS and nanotechnologies for both therapeutics and diagnostics.

Subject Categories

BISAC Subject Codes/Headings:
MED000000
MEDICAL / General
MED002000
MEDICAL / Administration
MED009000
MEDICAL / Biotechnology
MED014000
MEDICAL / Clinical Medicine
TEC021000
TECHNOLOGY & ENGINEERING / Material Science