Biomedical Applications of Mesoporous Ceramics: Drug Delivery, Smart Materials and Bone Tissue Engineering, 1st Edition (Hardback) book cover

Biomedical Applications of Mesoporous Ceramics

Drug Delivery, Smart Materials and Bone Tissue Engineering, 1st Edition

By María Vallet-Regí, Miguel Manzano García, Montserrat Colilla

CRC Press

231 pages | 20 Color Illus. | 117 B/W Illus.

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pub: 2012-11-28
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Developments in mesoporous ceramics in drug delivery, nanomedicine, and bone tissue regeneration have opened promising developments in biomedical research, many applicable in the clinic in the near future. Due to the ability to fine-tune the physicochemical properties of these materials, the field has experienced an impressive burst in the number of publications. As controlled drug delivery systems are one of the most promising applications for human health care, it is now necessary to set the milestones of this technology, from the very basic to the most advanced.

Biomedical Applications of Mesoporous Ceramics: Drug Delivery, Smart Materials and Bone Tissue Engineering is a comprehensive overview of silica-based mesoporous materials with special attention given to their use in drug delivery systems, sophisticated stimuli-responsive materials, and bone tissue engineering. The book provides a comprehensive overview of the basic aspects of the properties of mesoporous materials, with a focus on textural properties such as surface and porosity. Starting from this consolidated knowledge, it then addresses various aspects of more sophisticated stimuli-responsive materials and bone tissue engineering, detailing the research and development of these biomedical applications.

Table of Contents

Biocompatible and Bioactive Mesoporous Ceramics

General Properties of Ordered Mesoporous Ceramics

Biodegradable and Bioactive Ceramics

Calcium Phosphates


Organic Functionalization of Ordered Mesoporous Ceramics

In Vitro Studies

In Vivo Studies

Mesoporous Ceramics as Drug Delivery Systems

Adsorption of Biomolecules

Release of Biomolecules

Oral Drug Delivery

Topical and Transdermal Drug Delivery

Local Drug Delivery

Targeted Drug Delivery

Stimuli-Responsive Drug Delivery Systems Based on Mesoporous Silica

pH as Release Trigger

Temperature as Release Trigger

Redox Potential as Release Trigger

Light as Release Trigger

Magnetic Field as Release Trigger

Ultrasounds as Release Trigger

Enzymes as Release Triggers

Antigens as Release Triggers

Aptamer Target as Release Trigger

Dual Stimuli as Release Trigger

Mesoporous Silica Nanoparticles in Nanomedicine

Drug Delivery


Gene Therapy


Hyperthermia-Based Therapy


Theranostic Nanomedicine

Biocompatibility and Toxicity

Bone Tissue Regeneration

Tissue Engineering

Bone Tissue Engineering

Biocompatibility of Ordered Mesoporous Silica

About the Authors

Maria Vallet-Regi is Head of the Department of Inorganic and Bioinorganic Chemistry and Faculty of Pharmacy at Universidad Complutense de Madrid, Spain.

Miguel Manzano is also with Universidad Complutense de Madrid, Spain.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biotechnology
SCIENCE / Chemistry / General