A significant new book on drug delivery to the eye
Biopharmaceutics of Ocular Drug Delivery examines the current physiological, anatomical, pharmaceutical/technological, and biopharmaceutical knowledge on ocular drug delivery. Leading ophthalmic researchers cover topics such as the formulation and usage of ophthalmic solutions and suspensions, the influence of surfactants and preservatives on ocular drug absorption, and new techniques that include bioadhesion and the use of hyaluronic acid as an ophthalmic vehicle. Promising research on new delivery systems for improved drug therapy is highlighted, including new pharmaceutical vehicles, inserts, liposomes, nanoparticles, and prodrugs.
Biopharmaceutics of Ocular Drug Delivery is one of the few books available on drug delivery to the eye and will be an important reference for ophthalmologists, pharmacologists, pharmaceutical researchers, and other scientists interested in the topic.
Table of Contents
Anatomy and Physiology of the Eye. Physiological Aspects of Ocular Drug Therapy (Johan Stjernschantz and Maria Astin). Formulation of Ophthalmic Solutions and Suspensions. Problems and Advantages (Marc M.M. Van Ooteghem). The Effects of Preservatives on Corneal Permeability of Drugs (Keith Green). Solid Polymeric Inserts/Disks as Drug Delivery Devices (Marco Fabrizio Saettone). The Development and Use of In Situ Formed Gels, Triggered by pH (Robert Gurny, Houssam Ibrahim, and Pierre Buri). Liposomes and Nanoparticles as Ocular Drug Delivery Systems (Michael Mezei and Dale Meisner). Use of Hyaluronic Acid in Ocular Therapy (Stephanie R. Bernatchez, Ola Camber, Cyrus Tabatabay, and Robert Gurny). Improved Ocular Drug Delivery by Use of Chemical Modification (Prodrugs) (Vincent H. L. Lee). Bioadhesives in Ocular Drug Delivery (Eliot M. Slovin and Joseph R. Robinson). Pharmacokinetics in Ocular Drug Delivery (Ronald D. Schoenwald). Index.
c. 224 pp., 7x10, due November 1992, ISBN 0-8493-7296-8.
Peter Edman, Ph.D., is Director of the Pharmaceutical Department at Astra Draco AB at Lund, Sweden. Dr. Edman obtained his training at the University of Uppsala, Sweden, receiving the M.S.Pharm. degree in 1977 and the Ph.D. degree in Pharmaceutical Biochemistry in 1981. He became an Associate Professor of Pharmaceutical Biochemistry in 1986 and Professor in Pharmaceutics/Drug Formulation in 1988., While working as an academician Dr. Edman has had positions as Section Leader in the Pharmaceutical Division of the Swedish Medical Products Agency (1983 to 1985) and Director of Pharmaceutical Research and Development at Pharmacia AB in Uppsala (1985 to 1991). His current research interests are in new drug delivery systems, especially those intended for nasal and ocular use. Parenteral administration of microspheres as a targeting system for drugs is another topic where he has published several research articles., Dr. Edman has authored a number of scientific publications, reviews, and book chapters and directed several M.S. and Ph.D. students. He is a member of the Board of the Pharmaceutical and Biopharmaceutical Section of the Swedish Academy of Pharmaceutical Sciences. He is also a member of the Controlled Release Society and the International Association for Pharmaceutical Technology (APV).