1st Edition

Brain Neurotrauma
Molecular, Neuropsychological, and Rehabilitation Aspects

Edited By

Firas H. Kobeissy

ISBN 9781466565982
Published February 25, 2015 by CRC Press
725 Pages 212 B/W Illustrations

USD $260.00

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Book Description

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research.

The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries.

Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Table of Contents

Experimental CNS Trauma: A General Overview of Neurotrauma Research; Jonathan Lifshitz

Combat TBI: History, Epidemiology and Injury Modes; Ralph G. DePalma


Development of Concepts in the Pathology of Traumatic Axonal and Traumatic Brain Injury; William L. Maxwell

Pathophysiology of Mild TBI: Implications for Altered Signaling Pathways; Robert A. Laskowski, Jennifer A. Creed, and Ramesh Raghupathi

Oxidative Stress, Brain-Edema, Blood-Brain Barrier Permeability and Autonomic Dysfunction from Traumatic Brain Injury; Hale Zerrin Toklu and Nihal Tümer

The Contributing Role of Lipid Peroxidation and Protein Oxidation in the Course of CNS Injury Neurodegeneration and Neuroprotection: An Overview; Edward D. Hall

IGF-1/IGF-R Signaling in Traumatic Brain Injury: Impact on Cell Survival, Neurogenesis, and Behavioral Outcome; Sindhu K. Madathil and Kathryn E. Saatman

Microglia in Experimental Brain Injury: Implications on Neuronal Injury and Circuit Remodeling; Megan N. Evilsizor, Helen F. Ray-Jones, Timothy W. Ellis, Jr., Jonathan Lifshitz, and Jenna M. Ziebell

Evaluating the Effects of APOE4 after Mild Traumatic Brain Injury in Experimental Models; Rebekah Mannix and William P. Meehan III

The Cytoprotective role of Prostaglandin D2 DP1 Receptor Against Neuronal Injury Following Acute Excitotoxicity and Cerebral Ischemia; Sylvain Doré and Abdullah Shafique Ahmad


Chronic Pain in Neurotrauma: Implications on Spinal Cord and Traumatic Brain Injury; Rabih A. Moshourab, Michael Schäfer, and Elie D. Al-Chaer

Nonconvulsive Seizures as Secondary Insults in Experimental Traumatic Brain Injury; Laura Stone McGuire, Amade Bregy, Justin Sick, W. Dalton Dietrich, Helen M. Bramlett, and Thomas Sick

Characterization and Management of Headache after Mild Traumatic Brain Injury; Sylvia Lucas

Traumatic Brain Injury (TBI)-Induced Spasticity: Neurobiology, Treatment, and Rehabilitation; Prodip Bose, Jiamei Hou, and Floyd J. Thompson


Techniques and Methods of Animal Brain Surgery: Perfusion, Brain Removal, and Histological Techniques; Jihane Soueid, Amaly Nokkari, and Joelle Makoukji

Controlled Cortical Impact Model; Nicole D. Osier, Jonathan R. Korpon, and C. Edward Dixon

A Two-Model Approach to Investigate the Mechanisms Underlying Blast-Induced Traumatic Brain Injury; Haoxing Chen, Shlomi Constantini, and Yun Chen

Acute Pathophysiology of Blast Injury: From Biomechanics to Experiments and Computations: Implications on Head and Polytrauma; Namas Chandra and Aravind Sundaramurthy

Modeling Fluid Percussion Injury: Relevance to Human Traumatic Brain Injury; Katharine Eakin, Rachel Rowe, and Jonathan Lifshitz


CNS Trauma Biomarkers and Surrogate Endpoints Pipeline from Bench to Bedside: A Translational Perspective; Tarek H. Mouhieddine, Leeanna El Houjeiri, Mirna Sabra, Ronald Hayes, and Stefania Mondello

The Use and Potential of pNF-H as a General Blood Biomarker of Axonal Loss: An Immediate Application for CNS Injury; Gerry Shaw

Exploring Serum Biomarkers for Mild Traumatic Brain Injury; Linda Papa, Damyan Edwards, and Michelle Ramia

Modeling the Neurobehavioral Consequences of Blast-Induced Traumatic Brain Injury Spectrum Disorder and Identifying Related Biomarkers; Denes V. Agoston and Alaa Kamnaksh

Magnetic Resonance Imaging Application in the Area of Mild and Acute Traumatic Brain Injury: Implication for Diagnostic Marker; Arnold Toth

Translational Metabolomics of Head Injury: Exploring Dysfunctional Cerebral Metabolism with ex Vivo NMR Spectroscopy-Based Metabolite Quantification; Stephanie M. Wolahan, Daniel Hirt, and Thomas C. Glenn

The Emerging Impact of microRNAs in Neurotrauma Pathophysiology and Therapy; Oneil G. Bhalala

Neuroproteome Dynamics in Modeled Brain Injury: A Systems Neurobiology Perspective; Pavel Lizhnyak, Hiyab Yohannes, and Andrew K. Ottens

Gene Interaction Hierarchy Analysis can be an Effective Tool for Managing Big Data Related to Unilateral Traumatic Brain Injury; Todd E. White and Byron D. Ford

Autoantibodies in CNS Trauma and Neuropsychiatric Disorders: A New Generation of Biomarkers; Firas Kobeissy and Rabih A. Moshourab

Systems Biology Application to Decipher Mechanisms and Novel Biomarkers in CNS Trauma; Chenggang Yu and Firas Kobeissy


Neuropathology of Mild Traumatic Brain Injury: Correlation to Neurocognitive and Neurobehavioral Findings; Erin D. Bigler

Blast-Related Mild Traumatic Brain Injury: Neuropsychological Evaluation and Findings; Nathaniel W. Nelson, Nicholas D. Davenport, and Scott R. Sponheim

Persistent Cognitive Deficits: Implications of Altered Dopamine in Traumatic Brain Injury; Hong Qu Yan, Nicole D. Osier, Jonathan Korpon, James W. Bales, Anthony E. Kline, Amy K. Wagner, and C. Edward Dixon


Rehabilitative Paradigms after Experimental Brain Injury: Relevance to Human Neurotrauma; Corina O. Bondi, Roya Tehranian-DePasquale, Jeffrey P. Cheng, Christina M. Monaco, Grace S. Griesbach, and Anthony E. Kline

Models of Posttraumatic Brain Injury Neurorehabilitation; Michelle D. Failla and Amy K. Wagner

Translational Considerations for Behavioral Impairment and Rehabilitation Strategies after Diffuse Traumatic Brain Injury; Theresa Currier Thomas, Taylor A. Colburn, Kelsey Korp, Aida Khodadad, and Jonathan Lifshitz

Endothelin, Cerebral Blood Flow, and Traumatic Brain Injury: Implications for a Future Therapeutic Target; Justin C. Graves and Christian W. Kreipke,

Application of Novel Therapeutic Agents for CNS Injury: NAAG Peptidase Inhibitors; Bruce G. Lyeth

Neuregulin-1 and Neurovascular Protection; Limin Wu, Samantha J. Walas, Wendy Leung, Eng H. Lo, and Josephine Lok

Potential Use of Calpain Inhibitors as Brain Injury Therapy; Emilio B. Cagmat, Joy D. Guingab-Cagmat, A.V. Vakulenko, R.L. Hayes, and John Anagli

Nanoparticles for Neurotherapeutic Drug Delivery in Neurodegenerative Disorders: Application in Neurotrauma; Mark S. Kindy and Alexey Vertegel

Stem Cell Therapy in Brain Trauma: Implications for Repair and Regeneration of Injured Brain in Experimental TBI Models; Andrew Rolfe and Dong Sun

Cortical Stimulation-Induced Structural Plasticity and Functional Recovery after Brain Damage; DeAnna L. Adkins

Cranial Nerve Noninvasive Neuromodulation: New Approach to Neurorehabilitation; Yuri Danilov, Kurt Kaczmarek, Kimberly Skinner, and Mitchell Tyler


Blast Injuries and Blast-Induced Neurotrauma Overview of Pathophysiology and Experimental Knowledge: Models and Findings; Ibolja Cernak

Animal Models for Concussion: Molecular and Cognitive Assessments—Relevance to Sport and Military Concussions; Hayde Bolouri and Henrik Zetterberg

The Problem of Neurodegeneration in Cumulative Sports Concussions: Emphasis on

Neurofibrillary Tangle Formation; Vassilis E. Koliatsos and Leyan Xu


Evidence for Beneficial and Adverse Effects of Alcohol in Animal Models and Clinical Studies of Traumatic Brain Injury; Anna N. Taylor and Richard L. Sutton

Modeling TBI-Induced Alterations in Alcohol Use Behaviors; James P. Caruso, Jennifer L. Lowing, and Alana C. Conti


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Firas Hosni Kobeissy is an assistant professor in the Department of Psychiatry of the University of Florida McKnight Brain Institute and serves as the associate scientific director of the Center for Neuroproteomics and Biomarkers Research. He earned his PhD from the University of Florida and has published in the field of brain injury biomarkers, neuroproteomics, and neurosystems biology. Dr. Kobeissy’s current research overlaps the fields of neuroscience and psychiatry with a focus on drug abuse neurotoxicity and traumatic brain injury neuroproteomics. He has published more than 70 peer-reviewed papers, reviews, and book chapters as well as co-edited three books. He has also co-authored five U.S. patents. Dr. Kobeissy serves as an editorial member on several journals related to proteomics, neuroscience, and brain injury and has been a member on several study sections of brain injury and stroke.

Stuart W. Hoffman is the scientific program manager of the brain injury portfolio in the rehabilitation research and development service at the U.S. Department of Veteran Affairs (VA) The portfolio is focused on promoting translational research that improves outcomes in veterans living with the chronic effects of stroke, traumatic brain injury, and its co-morbidities. He also represents VA/ORD on TBI research. In this role, he is the co-chair of the government steering committee for the VA/DoD Chronic Effects of Neurotrauma Consortium, as well as a member of several advisory boards for VA research centers, and serves on the congressionally mandated Traumatic Brain Injury Advisory Committee for the Veterans Health Administration. He received his doctoral degree in behavioral and molecular neuroscience at Rutgers University.


"As traumatic brain injury is now well recognized as a world health issue, this text is timely and well deserving in terms of a review or our current understanding of several topics related to traumatic brain injury and recovery of function. [It] is a "must read" for all investigators interested in the field as this text will cover the current advancements in scientific technology, clinical care and, most importantly, the undeniable value of translational research."
—David A. Hovda, PhD, Director, UCLA Brain Injury Research Center

"[An] appealing package of knowledge in the mechanisms, epidemiology, psychology, pathology, diagnosis, treatment and rehabilitation of traumatic brain injuries."
—Mårten Risling MD, PhD, Professor, Department of Neuroscience, Karolinska Institutet

"Broad in its scope and coverage, [the book] is sure to be an outstanding resource for anyone interested in the pathophysiology or treatment of military or civilian head trauma."
—Gregory Elder, MD, Research Professor, Psychiatry, Icahn School of Medicine at Mount Sinai