Brain and Spinal Tumors of Childhood  book cover
1st Edition

Brain and Spinal Tumors of Childhood

ISBN 9780340762608
Published July 29, 2004 by CRC Press
552 Pages 17 Color & 284 B/W Illustrations

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Book Description

Children with brain and spinal tumors account for 20-25% of childhood cancers. Until the early 1990s there had been little progress in the development of new treatments, and outcomes were not improving despite advances seen in other childhood cancers. During the past 10 years, however, there has been a dramatic increase in interest in the subject among pediatric specialists worldwide, and new multi-disciplinary teams have become established. There are encouraging early signs of improvement in outcomes, and more are anticipated.

The appearance of this comprehensive, but practical, evidence-based review of brain and spinal tumors in children is therefore very timely. The content includes detailed coverage of the diagnosis, clinical management, after care and monitoring, and underlying biology of brain and spinal tumors in children. International in approach, it draws on the experience of the European Childhood Brain Tumour Committee, linked to the International Society of Paediatric Oncology, and various multi-centre clinical trials to reflect the various approaches to management that have arisen around the world.

Table of Contents

Part 1. Introduction
      1 Introduction
      2 The historical basis of neuro-oncology
Part 2. Epidemiology
      3 Epidemiology
      4 Biology
           (a) Neuroembryology
           (b) Tumor biology
      5 Pathology and molecular classification
Part 3. Diagnosis and treatment planning
      6 Clinical syndromes
      7 Diagnostic imaging
      8 Clinical trials
Part 4. Treatment techniques and neurotoxicities
      9 Neurosurgical techniques
      10 Radiotherapy techniques
      11 Neuropsychological outcome
      12 Drug delivery
Part 5. Disease-specific multi-disciplinary management
      13 Astrocytic tumors – low grade
           (a) General considerations
           (b) Treatment considerations by primary site and tumor dissemination
      14 Astrocytic tumors – high grade
      15 Brain stem tumors
      16 Embryonic tumors
      17 Ependymal tumors
      18 Germ cell tumors
           (a) Germ cell tumors of the central nervous system
           (b) A commentary
      19 Infant brain tumors
      20 Craniopharyngioma
      21 Intradural spinal tumors
      22 Rare tumors
      23 Exploiting biology for therapeutic gain
Part 6. Late consequences & supportive care
      24 Toxicity and late effects
      25 Physical care, rehabilitation and complementary therapies
      26 Cognitive development and educational rehabilitation
      27 Quality of life
      28 Information needs for children and families
      29 Future challenges

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David A. Walker BMedSci BM BS FRCP FRCPCH
Reader and Honorary Consultant in Paediatric Oncology, Division of Child Health, School of Human Development, University of Nottingham, Queen's Medical Centre, Nottingham, UK

Giorgio Perilongo MD
Consultant Paediatric Oncologist, Neuro-oncology Program, Division of Hematology/Oncology, Department of Pediatrics, University Hospital of Padova, Italy

Jonathan A. G. Punt MB BS FRCS FRCPCH
Formerly Senior Lecturer in Paediatric Neurosurgery and Consultant Paediatric Neurosurgeon, Children's Brain Tumour Research Centre, Nottingham, UK

Roger E. Taylor MA MB BS FRCP(Edin) FRCP FRCR
Consultant Clinical (Radiation) Oncologist, Cookridge Hospital, Leeds, UK


... an excellent reference book for all practitioners at any level in neurology, neurosurgery and oncology... [it] has many unique features, which make it a 'must have' textbook for all who care for children with CNS tumours.
British Journal of Cancer

In the introduction to this excellent book a stated aim is 'to further develop neuro-oncology paediatirc practise and facilitate service development' . Certainly in the UK the driving force of Clinical Governance quite correctly focuses clinicians' minds to the provision of gold standard care, I feel this book contributes greatly in laying down 'the mark' in the definition of such a standard in paediatric neuro-oncology.

This book set out to develop the sub-speciality of paediatric neuro-oncology. It is an immense achievement to bring together the list of eminent contributors to a single coherent readable text. The editors have certainly achieved their original aim and I have no reservation in recommending this text as a valuable aid to all involved in the multidisciplinary care of children with brain and spinal tumours.
Clinical Oncology 17:204

The last word of the editors of this most enjoyable book says that 'pediatric neuro-oncology is an expanding and specialised that needed a new book. A better book? Well we are already working on it.' We are looking forward to reading another new contribution of the same quality from such an experienced group of authors.
European Neurology