Calcium in Cell Cycles and Cancer: 2nd Edition (Hardback) book cover

Calcium in Cell Cycles and Cancer

2nd Edition

By James F. Whitfield

CRC Press

242 pages

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Hardback: 9780849344206
pub: 1995-04-24
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Description

The second edition of Calcium in Cell Cycles and Cancer presents a unique overview of calcium's roles in the several stages of cell cycles initiated by signals from "velcroceptors" and other kinds of growth-factor receptors. This book integrates the actions of calcium and its partner, cyclic AMP, with those of the growing family of newly discovered, stage-specific, cyclin-dependent protein kinases of the "cell cycle engine." The book also shows calcium to be a terminal, ultimately apoptogenic differentiator of colon and skin cells, as well as a major player in lymphocyte selection, activation, and proliferation. This edition relates and explains the dramatic changes in calcium's involvement in the cell cycle and the triggering of terminal differentiation programs that happen during carcinogenesis and are important keys to understanding cancer.

Table of Contents

Origins

The Viral Muds

The Prokaryotes

The Great Calcium-Driven Revolution

References

Calcium, Cyclic AMP, and Velcroceptor-Started Cycles

Introduction

The Cycle

The Proliferative Wakening: From Quiescence to G1 Build-Up

The G1 Build-Up

The S-Phase

Mitosis

Termination of the Proliferative Response

Hepatoma Cells

References

Cyclic AMP as a Mitogen

Introduction

Thyroid

Normal Thyrocytes

Goiters and Cancer

Parotid Gland

Adrenal Cortex

References

Calcium as Differentiator and Killer I

Keratinocytes

Normal Keratinocytes

Summary

References

Calcium as Differentiator and Killer II

Colon Cells

Normal Colon Cells

Colon Cancer

References

Lymphocytes

T-Lymphocytes

B-Lymphocytes

Leukemias and Lymphomas

References

Overview and Afterword: A Final Tribute to Ca2+

Abbreviations

Index

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
MED062000
MEDICAL / Oncology
SCI017000
SCIENCE / Life Sciences / Cytology