Calcium in Cell Cycles and Cancer  book cover
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2nd Edition

Calcium in Cell Cycles and Cancer



ISBN 9780849344206
Published April 24, 1995 by CRC Press
242 Pages

 
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Book Description

The second edition of Calcium in Cell Cycles and Cancer presents a unique overview of calcium's roles in the several stages of cell cycles initiated by signals from "velcroceptors" and other kinds of growth-factor receptors. This book integrates the actions of calcium and its partner, cyclic AMP, with those of the growing family of newly discovered, stage-specific, cyclin-dependent protein kinases of the "cell cycle engine." The book also shows calcium to be a terminal, ultimately apoptogenic differentiator of colon and skin cells, as well as a major player in lymphocyte selection, activation, and proliferation. This edition relates and explains the dramatic changes in calcium's involvement in the cell cycle and the triggering of terminal differentiation programs that happen during carcinogenesis and are important keys to understanding cancer.

Table of Contents

Origins
The Viral Muds
The Prokaryotes
The Great Calcium-Driven Revolution
References
Calcium, Cyclic AMP, and Velcroceptor-Started Cycles
Introduction
The Cycle
The Proliferative Wakening: From Quiescence to G1 Build-Up
The G1 Build-Up
The S-Phase
Mitosis
Termination of the Proliferative Response
Hepatoma Cells
References
Cyclic AMP as a Mitogen
Introduction
Thyroid
Normal Thyrocytes
Goiters and Cancer
Parotid Gland
Adrenal Cortex
References
Calcium as Differentiator and Killer I
Keratinocytes
Normal Keratinocytes
Summary
References
Calcium as Differentiator and Killer II
Colon Cells
Normal Colon Cells
Colon Cancer
References
Lymphocytes
T-Lymphocytes
B-Lymphocytes
Leukemias and Lymphomas
References
Overview and Afterword: A Final Tribute to Ca2+
Abbreviations
Index

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