Cancer Nanotechnology: Principles and Applications in Radiation Oncology, 1st Edition (Hardback) book cover

Cancer Nanotechnology

Principles and Applications in Radiation Oncology, 1st Edition

Edited by Sang Hyun Cho, Sunil Krishnan

CRC Press

296 pages | 22 Color Illus. | 127 B/W Illus.

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Hardback: 9781439878750
pub: 2013-01-08
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Rapid advances in nanotechnology have enabled the fabrication of nanoparticles from various materials with different shapes, sizes, and properties, and efforts are ongoing to exploit these materials for practical clinical applications. Nanotechnology is particularly relevant in the field of oncology, as the leaky and chaotic vasculature of tumors—a hallmark of unrestrained growth—results in the passive accumulation of nanoparticles within tumors.

Cancer Nanotechnology: Principles and Applications in Radiation Oncology is a compilation of research in the arena of nanoparticles and radiation oncology, which lies at the intersection of disciplines as diverse as clinical radiation oncology, radiation physics and biology, nanotechnology, materials science, and biomedical engineering. The book provides a comprehensive, cross-disciplinary survey of basic principles, research techniques, and outcomes with the goals of eventual clinical translation.

Coverage includes

  • A general introduction to fabrication, preferential tumor targeting, and imaging of nanoparticles
  • The specific applications of nanomaterials in the realms of radiation therapy, hyperthermia, thermal therapy, and normal tissue protection from radiation exposure
  • Outlooks for future research and clinical translation including regulatory issues for ultimate use of nanomaterials in humans

Reflecting profound advances in the application of nanotechnology to radiation oncology, this comprehensive volume demonstrates how the unique physicochemical properties of nanoparticles lead to novel strategies for cancer treatment and detection. Along with various computational and experimental techniques, each chapter highlights the most promising approaches to the use of nanoparticles for radiation response modulation.

Table of Contents

Basic Principles of Radiation Oncology and Radiosensitization

Basic Principles of Radiation Therapy of Cancers

Laurence Court and Radhe Mohan

Biological Principles of Radiosensitization

Vikas Bhardwaj, M. Angelica Cortez, Mohamad Fakhreddine, and James Welsh

Principles and Application of Hyperthermia Combined with Radiation

Mark Hurwitz

Synthesis, Safety, and Imaging of Nanomaterials for Cancer Applications

Synthesis and Surface Modification of Nanomaterials for Tumor Targeting

Glenn Goodrich

Safety Concerns for Nanomaterials in Nanomedicinal Applications

Qingxin Mu, Yi Zhang, Aijuan Liu, Nana Liang, Yanyan Liu, Yan Mu, Gaoxing Su, and Bing Yan

Imaging with Nanoparticles

Amit Joshi

Optical Microscopy of Plasmonic Nanoparticles

Varun P. Pattani and James W. Tunnell

X-ray Fluorescence Computed Tomography Imaging of Nanoparticles

Bernard L. Jones and Sang Hyun Cho

Nanomaterials for Radiation Therapy

Gold Nanoparticle–Mediated Radiosensitization

Devika B. Chithrani

Quantification of Gold Nanoparticle–Mediated Radiation Dose Enhancement

Sang Hyun Cho and Bernard L. Jones

Semiconductor Nanomaterials for Radiotherapy

Ke Sheng

Radioactive Gold Nanoparticles for Tumor Therapy

Raghuraman Kannan, Kattesh V. Katti and Cathy Cutler

Nanoparticles for Selective Radioprotection of Normal Tissues

Jacob M. Berlin and Kathy A. Mason

Nanomaterials for Hyperthermia and Thermal Therapy

Gold Nanoparticle–Mediated Hyperthermia in Cancer Therapy

Dev K. Chatterjee and Sunil Krishnan

Magnetic Resonance Temperature Imaging for Gold Nanoparticle–Mediated Thermal Therapy

R. Jason Stafford and John D. Hazle

Modeling of Plasmonic Heat Generation from Gold Nanoparticles

Francisco Reynoso and Sang Hyun Cho

Carbon Nanotubes for Thermal Therapy

Ravi N. Singh, Peter Alexander, Andrew R. Burke, Frank M. Torti, and Suzy V. Torti

Future Outlook

Regulatory Issues for Clinical Translations

J. Donald Payne

Clinical Translations of Nanotechnology: Present and Future Outlook

Dev K. Chatterjee, Sang Hyun Cho, and Sunil Krishnan

About the Series

Imaging in Medical Diagnosis and Therapy

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Oncology
SCIENCE / Biotechnology
SCIENCE / Physics