Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in mammalian cells, a novel role was proposed for this e
Preface. Cell Death by Energy Depletion: Discovery and Early Developments. Oxidative Stress and PARS Activation. Nitrosative Stress and PARS Acitvation. PARS in Regulating Cell Necrosis and Apoptosis. PARS in Mediating Neuronal Injury in Stroke and Neurotrauma. PARS in Mediating Chronic Neurodegeneration. PARS Activation and Myocardial Reperfusion Injury. Role of PARS Activation in the Pathophysiology of Endotoxic and Hemorrhagic Shock. Role of PARS Activation in Diabetes. PARS Activation and Arthritas. PARS Activation and Inflammatory Bowel Disease. PARS in Regulating Macrophage Activation and Gene Expression. Pharmacological Inhibitors of PARS.