Central Nervous System Trauma : Research Techniques book cover
1st Edition

Central Nervous System Trauma
Research Techniques

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ISBN 9780849380945
Published July 27, 1995 by CRC Press
592 Pages

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Book Description

Central nervous system trauma, which
encompasses stroke, subarachnoid hemorrhage, head injury, and spinal cord injury, is a leading cause of death in developed countries. In the search for underlying mechanisms, membrane involvement has been the common link. This fourth volume in the Membrane-Linked Diseases series is therefore dedicated to research on CNS trauma.
Focusing on the mechanism of membrane damage, Central Nervous System Trauma: Research Techniques presents a variety of experimental techniques to study the mechanism of CNS trauma. Animal and tissue culture models provide the bulk of the research findings in this area. Possible pharmacological interventions are analyzed. This volume offers numerous illustrative examples, including full color figures. This book serves as a valuable resource for students and researchers, assisting in the comprehension of current trends in CNS trauma and helping to stimulate the discovery of new research areas.

Table of Contents

CNS Trauma Research Using Small Animals, S.T. Ohnishi
Mechanisms of CNS Injury
Effects of Hypoxia and Hyperoxia on CNS, D. Torbati
Role of Calcium in CNS Trauma, M. Mattson
Role of Magnesium in CNS Trauma, R. Vink and T.K. McIntosh
Ion Movements and Edema Formation in CNS Injury, T. Tominaga and S.T. Ohnishi
Surgical Injury Role Models
Brain Study
A Global Ischemia Model: The Use of Na, K-ATPase Analysis, S. Karpiak
Forebrain Ischemia in the Rat: The Four-Vessel Occlusion Model, T. Mima
A Focal Cerebral Ischemia Model Designed For Basic Research and Experimental Interventions, R. Paczynski, Y.Y. He, S.T. Chen, and C.Y. Hsu
Reversible Focal Cerebral Ischemia in Rats: Middle Cerebral Artery Occlusion by Intraluminal Suture, H. Karibe, A. Mancuso, and P.R. Weinstein
A Model of Transient Cerebral Focal Ischemia in the Mouse, H. Kamii, H. Kinouchi, F.R. Sharp, and P.H. Chan
Murine Models of Cerebral Ischemia, F.C. Barone, R.N. Willette, R.K. Clark, A.H. Nelson, G.Z. Feuerstein, H.M. Sarau, M.N. Tsimas, D.B. Schmidt, R.D. Kapadia, and S.K. Sarkar
Concepts and Techniques of Experimental Strokes Induced by Cerebrovascular Photothrombosis, B.D. Watson, W.D. Dietrich, R. Prado, H. Nakayama, H. Kanemitsu, N.N. Futrell, H. Yao, C. G. Markgraf, and P. Webster
Subarachnoid Hemorrhage Model, T. Matsui and T. Asano
Head Injury Models
The Mouse Head Injury Model: Utility in the Discovery of Acute Cerebroprotective Agents, E. Hall
A Controlled impact Model of Mouse Head Injury, S.T. Ohnishi and J.H. Mullen, Jr.
A Closed Head Injury Model In the Rat, E. Shohami, S. Cotev, and Y. Shapira
Weight Drop Model of Traumatic Brain Injury: Assessment of the Acute Inflammatory Response to Cerebral Trauma, P. Kochanek, R. Clark, J.K. Schiding, and E.M. Nemoto
Rodent Models of Traumatic Brain Injury and Motor Function Assessment: Controlled Cortical Impact Model and Fluid Percussion Models of Traumatic Brain Injury, C.E. Dixon and R.L. Hays
Spinal Cord Study
A Model of Spinal Cord Ischemia, P.C. Francel, J.A. Jane, and I. Kron
Spinal Cord Injury Modeling and Functional Assessment, B.T. Stokes, P.J. Horner, and M. Akino
A Weight Free-Drop Technique to Produce Spinal Cord Injury and a Simple Motor Function Test, S.T. Ohnishi, K.K. Sadanaga, and J.H. Mullen, Jr.
Behavioral Study
The Assessment of Cognitive Function Following Traumatic Brain Injury, R. Hamm
Tissue Culture and Tissue Slice Models
In Vitro Models of Ischemia Injury, C. Shin and X. Sun
Brain Slices in the Study of CNS Trauma, P.G. Aitken
Organotypic Spinal Cord Cultures and A Model of Chronic Glutamate-Mediated Motor Neuron Degeneration, A.M. Corse and J.D. Rothstein
Tissue Culture Studies of Neuronal Responses to Physical Lesions of the Plasma Membrane: Environmental Influences and Experimental Interventions, J.H. Lucas
Micro Techniques
Application of Microdialysis for CNS Injury Study, Y. Katayama
Measurement of Glutamate and Other Neurotransmitters in Ischemic Brain By Microdialysis: Effect of Hypothermia and Hyperthermia, M.D. Ginsberg, R. Busto, and M.Y.T. Globus
A Microdialysis Model for Identifying Agents of Secondary Damage in Spinal Cord Injury, D. Liu and D.J. McAdoo
Molecular Biological Approach to CNS Injury
Post-Ischemic Gene Regulation, C.Y. Hsu, Z.Y. Hu, A. Salminen, B.J. Gwag, and P.K. Liu
SOD-1 Transgenic Mice: An Application to the Study of Ischemic Brain Injury, H. Kamii, H. Kinouchi, S.F. Chen, F.R. Sharp, and P.H. Chan
Free Radicals and Lipid Peroxidation
Improvement in the Salicylate Trapping Method for Measurement of Hydroxyl Radical Levels in the Brain, J.S. Althous, P.K. Andrus, E. Hall, and P.R. Vonvoigtlander
Trapping of Oxygen Free Radicals in Brain Ischemia and Reperfusion, A. Sakamoto, R. Ogawa, and S.T. Ohnishi
Direct Measurement of Nitric Oxide in the Rat Brain Subjected to the Occlusion of the Middle Cerebral Artery, T. Matsui
Nitric Oxide and Superoxide-Mediated Tissue Injury: Detecton of Peroxynitrite, H. Ischiropoulos
Histological Techniques
Histopathology after Traumatic Brain Injury, R.L. Sutton
Biochemical Immunohistology, P.M. Martin and J.P. O'Callaghan
Topics with Growing Interest
Chronic Alcoholism and Brain Ischemia, T. Tominaga and S.T. Ohnishi
Gun-Shot Wounds of the Brain, D. Torbati

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