Central Nervous System Trauma: Research Techniques, 1st Edition (Hardback) book cover

Central Nervous System Trauma

Research Techniques, 1st Edition

By S. Tsuyoshi Ohnishi, Tomoko Ohnishi

CRC Press

592 pages

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Hardback: 9780849380945
pub: 1995-07-27
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Description

Central nervous system trauma, which

encompasses stroke, subarachnoid hemorrhage, head injury, and spinal cord injury, is a leading cause of death in developed countries. In the search for underlying mechanisms, membrane involvement has been the common link. This fourth volume in the Membrane-Linked Diseases series is therefore dedicated to research on CNS trauma.

Focusing on the mechanism of membrane damage, Central Nervous System Trauma: Research Techniques presents a variety of experimental techniques to study the mechanism of CNS trauma. Animal and tissue culture models provide the bulk of the research findings in this area. Possible pharmacological interventions are analyzed. This volume offers numerous illustrative examples, including full color figures. This book serves as a valuable resource for students and researchers, assisting in the comprehension of current trends in CNS trauma and helping to stimulate the discovery of new research areas.

Table of Contents

Introduction

CNS Trauma Research Using Small Animals, S.T. Ohnishi

Mechanisms of CNS Injury

Effects of Hypoxia and Hyperoxia on CNS, D. Torbati

Role of Calcium in CNS Trauma, M. Mattson

Role of Magnesium in CNS Trauma, R. Vink and T.K. McIntosh

Ion Movements and Edema Formation in CNS Injury, T. Tominaga and S.T. Ohnishi

Surgical Injury Role Models

Brain Study

A Global Ischemia Model: The Use of Na, K-ATPase Analysis, S. Karpiak

Forebrain Ischemia in the Rat: The Four-Vessel Occlusion Model, T. Mima

A Focal Cerebral Ischemia Model Designed For Basic Research and Experimental Interventions, R. Paczynski, Y.Y. He, S.T. Chen, and C.Y. Hsu

Reversible Focal Cerebral Ischemia in Rats: Middle Cerebral Artery Occlusion by Intraluminal Suture, H. Karibe, A. Mancuso, and P.R. Weinstein

A Model of Transient Cerebral Focal Ischemia in the Mouse, H. Kamii, H. Kinouchi, F.R. Sharp, and P.H. Chan

Murine Models of Cerebral Ischemia, F.C. Barone, R.N. Willette, R.K. Clark, A.H. Nelson, G.Z. Feuerstein, H.M. Sarau, M.N. Tsimas, D.B. Schmidt, R.D. Kapadia, and S.K. Sarkar

Concepts and Techniques of Experimental Strokes Induced by Cerebrovascular Photothrombosis, B.D. Watson, W.D. Dietrich, R. Prado, H. Nakayama, H. Kanemitsu, N.N. Futrell, H. Yao, C. G. Markgraf, and P. Webster

Subarachnoid Hemorrhage Model, T. Matsui and T. Asano

Head Injury Models

The Mouse Head Injury Model: Utility in the Discovery of Acute Cerebroprotective Agents, E. Hall

A Controlled impact Model of Mouse Head Injury, S.T. Ohnishi and J.H. Mullen, Jr.

A Closed Head Injury Model In the Rat, E. Shohami, S. Cotev, and Y. Shapira

Weight Drop Model of Traumatic Brain Injury: Assessment of the Acute Inflammatory Response to Cerebral Trauma, P. Kochanek, R. Clark, J.K. Schiding, and E.M. Nemoto

Rodent Models of Traumatic Brain Injury and Motor Function Assessment: Controlled Cortical Impact Model and Fluid Percussion Models of Traumatic Brain Injury, C.E. Dixon and R.L. Hays

Spinal Cord Study

A Model of Spinal Cord Ischemia, P.C. Francel, J.A. Jane, and I. Kron

Spinal Cord Injury Modeling and Functional Assessment, B.T. Stokes, P.J. Horner, and M. Akino

A Weight Free-Drop Technique to Produce Spinal Cord Injury and a Simple Motor Function Test, S.T. Ohnishi, K.K. Sadanaga, and J.H. Mullen, Jr.

Behavioral Study

The Assessment of Cognitive Function Following Traumatic Brain Injury, R. Hamm

Tissue Culture and Tissue Slice Models

In Vitro Models of Ischemia Injury, C. Shin and X. Sun

Brain Slices in the Study of CNS Trauma, P.G. Aitken

Organotypic Spinal Cord Cultures and A Model of Chronic Glutamate-Mediated Motor Neuron Degeneration, A.M. Corse and J.D. Rothstein

Tissue Culture Studies of Neuronal Responses to Physical Lesions of the Plasma Membrane: Environmental Influences and Experimental Interventions, J.H. Lucas

Micro Techniques

Application of Microdialysis for CNS Injury Study, Y. Katayama

Measurement of Glutamate and Other Neurotransmitters in Ischemic Brain By Microdialysis: Effect of Hypothermia and Hyperthermia, M.D. Ginsberg, R. Busto, and M.Y.T. Globus

A Microdialysis Model for Identifying Agents of Secondary Damage in Spinal Cord Injury, D. Liu and D.J. McAdoo

Molecular Biological Approach to CNS Injury

Post-Ischemic Gene Regulation, C.Y. Hsu, Z.Y. Hu, A. Salminen, B.J. Gwag, and P.K. Liu

SOD-1 Transgenic Mice: An Application to the Study of Ischemic Brain Injury, H. Kamii, H. Kinouchi, S.F. Chen, F.R. Sharp, and P.H. Chan

Free Radicals and Lipid Peroxidation

Improvement in the Salicylate Trapping Method for Measurement of Hydroxyl Radical Levels in the Brain, J.S. Althous, P.K. Andrus, E. Hall, and P.R. Vonvoigtlander

Trapping of Oxygen Free Radicals in Brain Ischemia and Reperfusion, A. Sakamoto, R. Ogawa, and S.T. Ohnishi

Direct Measurement of Nitric Oxide in the Rat Brain Subjected to the Occlusion of the Middle Cerebral Artery, T. Matsui

Nitric Oxide and Superoxide-Mediated Tissue Injury: Detecton of Peroxynitrite, H. Ischiropoulos

Histological Techniques

Histopathology after Traumatic Brain Injury, R.L. Sutton

Biochemical Immunohistology, P.M. Martin and J.P. O'Callaghan

Topics with Growing Interest

Chronic Alcoholism and Brain Ischemia, T. Tominaga and S.T. Ohnishi

Gun-Shot Wounds of the Brain, D. Torbati

Index

About the Series

Membrane Linked Diseases

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED056000
MEDICAL / Neurology
MED106000
MEDICAL / Research
SCI089000
SCIENCE / Life Sciences / Neuroscience