622 pages | 41 Color Illus. | 156 B/W Illus.
Chemical Biology of Natural Products
This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds.
Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes.
Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.
Chapter 1: Microbial Genome Mining for Natural Product Drug Discovery
Chapter 2: Chemical Biology of Marine Cyanobacteria
Chapter 3: The Role of Combinatorial Biosynthesis in Natural Products Discovery
Chapter 4: The Generation of New to Nature Natural Products Through Synthesis and Biosynthesis: Blending Synthetic Biology with Synthetic Chemistry
Chapter 5: Terrestrial Microbial Natural Products Discovery Guided by Symbiotic Interactions and Revealed by Advanced Analytical Methods
Chapter 6: Natural Products from Endophytic Microbes. Historical Perspectives, Prospects, and Guidance
Chapter 7: Novel Insights in Plant Endophyte Interactions
Chapter 8: Microbial Co-culture and OSMAC Approach as Strategies to Induce Cryptic Fungal Biogenetic Gene Clusters
Chapter 9: Natural Products of the Rhizosphere and Its Microorganisms: Bioactivities and Implications of Occurrence
Chapter 10: Novel Metabolites fromExtremophilic Microbes Isolated from Toxic Waste Sites
Chapter 11: Deep-Sea Hydrothermal Vent Organisms as Sources of Natural Products
Chapter 12: Cone Snail Venom Peptides and Future Biomedical Applications of Natural Products
Chapter 13: Naturally Occurring Disulfide-rich Peptides from Plants and Animals: Synthesis and Biosynthesis
Chapter 14: Synthesis and Target Identification of Natural Product Inspired Compound Collections
Chapter 15: On The Chemistry and Biology of the Marine Macrolides Zampanolide and Dactylolide