Chemical and Structural Approaches to Rational Drug Design: 1st Edition (Hardback) book cover

Chemical and Structural Approaches to Rational Drug Design

1st Edition

Edited by David B. Weiner, William V. Williams

CRC Press

288 pages

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Hardback: 9780849378188
pub: 1994-11-28
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This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.

Table of Contents

Chemical Approaches to Rational Drug Design

Design, Synthesis and Antitumor Activity of an Inhibitor of Ribonucleotide Reductase, J.R. McCarthy and P.S. Sunkara.

The Development of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors, A. Stern.

The Development of Potent Angiotensin II Receptor Antagonists Using a Novel Peptide Pharmacophore Model, R.M. Keenan, J. Weinstock, J.C. Hempel, J.M. Samanen, D.T. Hill, N. Aiyar, E.H. Ohlstein, and R.M. Edwards.

Endothelin Structure and Development of Receptor Antagonists, A.M. Doherty.

Molecular Targeting Chemistry in Rational Drug Design, A. Fritzberg, L. Gustavson, M. Hylarides, and J. Reno.

Structural Approaches to Rational Drug Design

The Role of X-Ray Crystallography in Structure-Based Rational Drug Design, A. McPherson.

Biocomputational Approaches to Protein-Based Drug Design, K. Prammer, M. Weiner, and T. Kieber-Emmons.

Architecture and Design of Zinc Protein-Ligand Complexes, D.W. Christianson and A.M. Khoury Christianson.

Design of Immunomodulatory Peptides Based on Active Site Structures, A.B. Mukherjee and L. Miele.


About the Series

Handbooks in Pharmacology and Toxicology

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology