Chemistry and Pharmacology of Anticancer Drugs: 1st Edition (Hardback) book cover

Chemistry and Pharmacology of Anticancer Drugs

1st Edition

By David E. Thurston, David E. Thurston

CRC Press

312 pages | 213 B/W Illus.

Purchasing Options:$ = USD
Hardback: 9780849392191
pub: 2006-11-22
SAVE ~$38.25
$255.00
$216.75
x
eBook (VitalSource) : 9780429118449
pub: 2006-11-22
from $28.98


FREE Standard Shipping!

Description

While drug therapies developed in the last 50 years have markedly improved the management of some types of cancers, treatment outcomes, and drug side-effects for the most common types remain unacceptable.  However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents currently in use or in advanced stages of clinical trials, including biologicals.

The book is unique in providing molecular structures for all anticancer drugs, discussing them in terms of history, chemistry, mechanism of action, structure-function relationships, and pharmacology. It also provides some relevant information on side effects, dosing, and formulation. The author, a renowned scientist in cancer research and drug development, also provides up-to-date information on the drug discovery process, including new research tools, tumor-targeting strategies, and fundamental concepts in the emerging areas of personalized medicine (e.g., oncogenomics) and chemoprevention.

Chemistry and Pharmacology of Anticancer Drugsis an indispensable resource for cancer researchers, medicinal chemists, and other biomedical scientists involved in the development of new anticancer treatments. Its breadth of coverage also makes it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, and related disciplines.

Reviews

”…This text is a gem for any graduate student in the pharmaceutical sciences or for anyone seeking an introductory reference in the area of anticancer drugs.”

— John S. Williamson, University of Mississippi, writing in the Journal of Medicinal Chemistry, Vol. 50, No. 26: December 27, 2007

"The author explains in the foreword that this, ‘book attempts to bring together a broad spectrum of information relating to the chemistry and pharmacology of anticancer drugs and therapies.’ The author succeeds in this aim in a very elegant text. The book is both informative and easy to read. It is a very interesting book and would be a welcome addition to any individual’s collection, and essential if this is your field."

– Steve Mitchell, Faculty of Medicine, Imperial College London in Imperial College of Science Technology, July 2008

". . . a noteworthy survey . . . The author, a renowned scientist in cancer research and drug development, clearly does not fail to provide up-to-date information on this trend in today’s pharmacology. A book that covers such a large number of anticancer drugs, ranging from those in clinical use to those under basic research, is nearly impossible to write. Dr. Thurston has done so, however, thanks to his expertise in the field . . . easy readability and directness make the book ideal for students . . . an indispensable resource for the libraries of research institutes, universities, and hospitals."

– Matteo Conti, Ospedales S. Maria delle Croci, Ravenna, Italy, in ChemMedChem, 2007, No. 2

"The book is unique in providing molecular structures for all anticancer drugs, discussing them in terms of history, chemistry, mechanism of action, structure-function relationships, and pharmacology . . . This volume is an indispensable resource for cancer researchers, medicinal chemists, and other biomedical scientists involved in the development of new anticancer treatments."

– In Anticancer Research, 2009, Vol. 29

"As written, the book does an excellent job for its intended audience of advanced undergraduates and health-care professionals in training or those with only peripheral exposure to cancer therapy . . . Overall, the book is easy to read and manages to not be redundant. This is all quite an accomplishment considering the topic."

– RA Sikes, University of Delaware, in British Journal of Cancer, 2007, Vol. 97

Table of Contents

INTRODUCTION TO CANCER

Terminology

Metastases

Diagnosis and Screening

Formation of Cancer Cells (Tumorigenesis)

Mechanisms of Genomic Damage

Treatments

Discovery of Anticancer Drugs and Preclinical Evaluation

Accessibility of Drugs to Tumor Cells

Achieving Selective Toxicity

Limiting the Toxicity of Chemotherapeutic Agents

Overview of Mechanisms of Action of Chemotherapeutic Agents

Drug Resistance

Combination Chemotherapy

Use of Adjuvants

Infertility Following Cancer Treatments

ANTIMETABOLITES

DHFR Inhibitors (Antifolates)

Purine Antimetabolites

Pyrimidine Antimetabolites

Thymidylate Synthase Inhibition

Adenosine Deaminase Inhibition

Ribonucleotide Reductase Inhibition

DNA-INTERACTIVE AGENTS

Alkylating Agents

Cross-Linking Agents

Intercalating Agents

Topoisomerase Inhibitors

DNA-Cleaving Agents

ANTITUBULIN AGENTS

Vinca Alkaloids

The Taxanes

MOLECULARLY TARGETED AGENTS

Kinase Inhibitors

Inhibition of Ras Pathway Signaling

Cell Cycle Inhibitors

Proteasome Inhibitors

mTOR Inhibitors

HORMONAL THERAPIES

Breast Cancer

Prostatic Cancer

Neuroendocrine Tumors: Somatostatin Analogs

Estrogen Therapy

Progestogen Therapy

TUMOR-TARGETING STRATEGIES

Antibody-Based Approaches

Vascular-Targeting Strategies

X-DEPT (Biphasic) Strategies

Enzymatic Targeting

Photoactivated Drugs (Photodynamic Therapy)

Boron Neutron Capture Therapy

Novel Drug Delivery Approaches

BIOLOGICAL AGENTS

Biological Response Modifiers

Immunotherapy

Enzyme-Based Therapies

Vaccines

THE FUTURE

Novel Biological Targets and Therapeutic Strategies

New Research Tools and Methodologies

Chemopreventive Agents

PERSONALIZED TREATMENTS

Screening for Risk of Disease Development

Prognosis and Staging

Screening for Risk of Recurrence of Disease

Selecting Best Treatments for Patients

Predicting Side Effects of Chemotherapeutic Agents

Pharmacogenomics in Clinical Trials

ADJUNCT THERAPIES

Anti-emetic Agents

Steroidal Agents

Adjuvent Enzymes

Other Therapies

Index

*Each chapter includes an Introduction and a Further Reading section.

Subject Categories

BISAC Subject Codes/Headings:
MED062000
MEDICAL / Oncology
MED071000
MEDICAL / Pharmacology
SCI013000
SCIENCE / Chemistry / General