Evolution of Ligand Libraries for Asymmetric Catalysis
- Available for pre-order. Item will ship after May 6, 2021
Many new drugs on the market are chiral compounds, that is, they can exist in two non-superimposable mirror-image forms. Asymmetric catalysis encompasses a large variety of processes for obtaining such compounds. The performance of the catalyst in those processes largely depends on the ligand that makes up the catalyst. This book describes the most relevant ligand libraries for some key processes, including an overview of the state of art and the key mechanistic aspects that favor a high catalytic performance.
- The book presents historical content from the time of discovery for each family of ligands.
- Provides a description of the synthetic route and the ligand library's application in various catalytic asymmetric reactions
- Suitable as supplementary reading for courses targeting the design, synthesis and application of chiral catalysts, asymmetric catalysis and sustainable production
- Edited by a distinguished scientist in the field, the book has a diverse audience including research groups in homogeneous catalysis, particularly asymmetric transformations
Table of Contents
About the Editor
List of Contributors
Chapter 1 Chiral bidentate heterodonor P-oxazoline ligands, Maria Biosca, Jordi Faiges, Montserrat Diéguez and Oscar Pàmies
Chapter 2 Chiral bidentate heterodonor P-N-other-ligands, Pep Rojo, Marina Bellido, Xavier Verdaguer and Antoni Riera
Chapter 3 Chiral bidentate heterodonor P-S/O ligands, Jèssica Margalefa and Miquel A. Pericàs
Chapter 4 Chiral Bidentate Heterodonor P-P’ ligands, Antonio Pizzano
Chapter 5 Chiral tridentate based ligands, Uchchhal Bandyopadhyay, Basker Sundararaju, Rinaldo Poli and Eric Manourya
Chapter 6 Chiral N-heterocyclic carbene-based ligands, Vincent César, Christophe Fliedel, Agnès Labande
Chapter 7 Chiral Monophosphorus Ligands, Wenjun Tang, Feng Wan and He Yang
Chapter 8 Solvent oriented ligand and catalyst design in asymmetric catalysis – Principles and limits, Armin Borner
Montserrat Diéguez studied chemistry at the Rovira i Virgili (URV) University in Tarragona (Spain), where she received her Ph.D. in 1997 working in the group of Prof. C. Claver. After a postdoctoral fellow with Prof. R.H. Crabtree at Yale University, in New Haven (USA), she returned to Tarragona in 1999 and accepted a lecturer position at the University Rovira i Virgili, becoming part of the permanent staff in 2002. In 2011 she was promoted to full Professor in Inorganic Chemistry at the University Rovira i Virgili in Tarragona. She has been involved in more than 60 research projects in the field of organometallic chemistry, steroselective synthesis and asymmetric catalysis. She is author of more than 150 articles in SCI indexed Journals and book chapters and of several contributions to Conferences. She obtained the Distinction from the Generalitat de Catalunya for the promotion of University Research in 2004 and from the URV in 2008. She has also been awarded with the ICREA Academia Prize 2009-14 and 2015-20, from the Catalan Institution for Research and Advanced Studies, for research excellence, facilitating research priority dedication. Her main research interests are focused on the sustainable design, synthesis and screening of highly active and selective chiral catalysts for reactions of interest in the biological, pharmaceutical and organic nanotechnological industry. Her areas of interest include organometallic chemistry, steroselective synthesis and asymmetric catalysis using combinatorial and biotechnological approaches.