Chiral Separations by Capillary Electrophoresis  book cover
1st Edition

Chiral Separations by Capillary Electrophoresis

ISBN 9780367384890
Published September 19, 2019 by CRC Press
543 Pages

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Book Description

Covers the Fundamentals of Chiral Separation, Available Chiral Selectors, and Numerous Applications of Chiral Separation by Capillary Electrophoresis

Since the 1980s, modern analytical tools have enabled capillary electrophoresis to become a standard part of the chemist’s toolkit. With contributions from international experts, Chiral Separations by Capillary Electrophoresis provides a general overview of the principles of chiral separation by capillary electrophoresis and the different chiral selectors available.

The book discusses the most important as well as several new chiral selectors used in capillary electrophoresis. It reviews recent pharmaceutical and biomedical applications and explores novel techniques, such as capillary electrophoresis coupled to mass spectrometry and microchip technology. The book also examines the quantitative aspects of capillary electrophoresis, the possibilities of capillary electrochromatography, and the various chiral columns available.

Capillary electrophoresis has proven to be an effective tool for chiral separation. This book explains how this technique can be used in the separation of molecules, offering insight into both existing and emerging applications.

Table of Contents

Pharmacological Importance of Chiral Separations. Principles of Chiral Separations by Free-Solution Electrophoresis. Cyclodextrin-Mediated Chiral Separations. Factors Influencing Cyclodextrin-Mediated Chiral Separations. Macrocyclic Antibiotics as Chiral Selectors. Chiral Separations Using Proteins and Peptides as Chiral Selectors. Chiral Ligand Exchange Capillary Electrophoresis. Chiral Separations by Micellar Electrokinetic Chromatography. Chiral Microemulsion Electrokinetic Chromatography. Chiral Separations in Nonaqueous Media. Quantitative Analysis in Pharmaceutical Analysis. Analysis of Chiral Drugs in Body Fluids. Chiral Capillary Electrophoresis-Mass Spectrometry. Enantioseparations by Capillary Electrochromatography. Recent Applications in Capillary Electrochromatography. Chiral Separations with Microchip Technology. Index.

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Ann Van Eeckhaut is a postdoctoral researcher in the Department of Pharmaceutical Chemistry and Drug Analysis in the School of Pharmacy at the Vrije Universiteit Brussel in Belgium.

Yvette Michotte is the head of the Department of Pharmaceutical Chemistry and Drug Analysis in the School of Pharmacy at the Vrije Universiteit Brussel in Belgium.