Chiral Separations by Capillary Electrophoresis: 1st Edition (Hardback) book cover

Chiral Separations by Capillary Electrophoresis

1st Edition

Edited by Ann Van Eeckhaut, Yvette Michotte

CRC Press

543 pages | 171 B/W Illus.

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Hardback: 9781420069334
pub: 2009-11-11
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Covers the Fundamentals of Chiral Separation, Available Chiral Selectors, and Numerous Applications of Chiral Separation by Capillary Electrophoresis

Since the 1980s, modern analytical tools have enabled capillary electrophoresis to become a standard part of the chemist’s toolkit. With contributions from international experts, Chiral Separations by Capillary Electrophoresis provides a general overview of the principles of chiral separation by capillary electrophoresis and the different chiral selectors available.

The book discusses the most important as well as several new chiral selectors used in capillary electrophoresis. It reviews recent pharmaceutical and biomedical applications and explores novel techniques, such as capillary electrophoresis coupled to mass spectrometry and microchip technology. The book also examines the quantitative aspects of capillary electrophoresis, the possibilities of capillary electrochromatography, and the various chiral columns available.

Capillary electrophoresis has proven to be an effective tool for chiral separation. This book explains how this technique can be used in the separation of molecules, offering insight into both existing and emerging applications.


"The book has a good plan and the authors have delivered on their assignments, With this one resource the reader can quickly obtain a current snapshot of the increasing use of capillary electrophoretic methods for the separation of the enantiomers of pharmaceutical compounds as well as the research that is currently underway to expand these methods."

Chromatographia, JAN 2011, 73:197-198

"…this book provides a thorough introduction to the fundamental reaction classes in organometallic chemistry and a systematic survey of important catalytic methods. Organic chemists with little or no formal training in transition-metal chemistry often find themselves using transition-metal reagents or catalysts, and such individuals will find this to be a particularly useful resource. Meanwhile, experienced researchers and others with a strong background in the field will appreciate the extensive compilation of leading references to primary journal and review articles, which are cited liberally throughout the volume. The logical and systematic presentation of content in the book is well suited to meet the needs of students and researchers alike … This book is destined to be the go-to resource for the field of transition-metal organometallic chemistry for many years to come. It will undoubtedly find a place on the bookshelf of virtually every organic and inorganic chemist, alongside classics like March's Advanced Organic Chemistry and Cotton and Wilkinson's Adlmnced Inorganic Chemistry."

—Shannon S. Stahl, Univeristy of Wisconsin-Madison, Journal of the American Chemical Society, Vol. 132 Issues 21-24, 2010

Table of Contents

Pharmacological Importance of Chiral Separations, Ann Van Eeckhaut and Yvette Michotte

Principles of Chiral Separations by Free-Solution Electrophoresis, Radim Vespalec

Cyclodextrin-Mediated Chiral Separations, Gerald Gübitz and Martin G. Schmid

Factors Influencing Cyclodextrin-Mediated Chiral Separations, Anne-Catherine Servais, Jacques Crommen, and Marianne Fillet

Macrocyclic Antibiotics as Chiral Selectors, Salvatore Fanali, Zeineb Aturki, Giovanni D’Orazio, and Anna Rocco

Chiral Separations Using Proteins and Peptides as Chiral Selectors, Jun Haginaka

Chiral Ligand Exchange Capillary Electrophoresis, Vincenzo Cucinotta and Alessandro Giuffrida

Chiral Separations by Micellar Electrokinetic Chromatography, Joykrishna Dey and Arjun Ghosh

Chiral Microemulsion Electrokinetic Chromatography, Kimberly A. Kahle and Joe P. Foley

Chiral Separations in Nonaqueous Media, Ylva Hedeland and Curt Pettersson

Quantitative Analysis in Pharmaceutical Analysis, Ulrike Holzgrabe, Claudia Borst, Christine Büttner, and Yaser Bitar

Analysis of Chiral Drugs in Body Fluids, Pierina Sueli Bonato, Valquira Aparcida Polisel Jabor, and Anderson Rodrigo Moraes de Oliveira

Chiral Capillary Electrophoresis-Mass Spectrometry, Serge Rudaz, Jean-Luc Veuthey, and Julie Schappler

Enantioseparations by Capillary Electrochromatography, Michael Lämmerhofer

Recent Applications in Capillary Electrochromatography, Debby Mangelings and Yvan Vander Heyden

Chiral Separations with Microchip Technology, Markéta Vlcková , Franka Kalman, and Maria A. Schwarz


About the Authors/Editors

Ann Van Eeckhaut is a postdoctoral researcher in the Department of Pharmaceutical Chemistry and Drug Analysis in the School of Pharmacy at the Vrije Universiteit Brussel in Belgium.

Yvette Michotte is the head of the Department of Pharmaceutical Chemistry and Drug Analysis in the School of Pharmacy at the Vrije Universiteit Brussel in Belgium.

About the Series

Chromatographic Science Series

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biotechnology
SCIENCE / Chemistry / Industrial & Technical
SCIENCE / Research & Methodology