Genomics and Pathogenesis
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Chlamydia is the perfect pathogen, remaining elusive to the host by hiding within its cells and to the researcher by being refractory to laboratory analysis. However the recent revolution in genomics and molecular biology have made a great impact on chlamydia research.
Every chapter in this book draws on recently acquired genomic information. Written by the rising stars of chlamydial research, this comprehensive book covers literally every aspect of Chlamydia molecular and cellular biology. The book is divided into four sections: comparative and functional genomics, molecular and cellular pathogenesis, host responses and disease, emerging strategies for control. Topics covered include comparative genomics, genomics of environmental Chlamydia, regulation of gene expression, tryptophan metabolism, chlamydiaphage, and much more. Essential reading for all chlamydia researchers and recommended reading for other scientists working in bacterial molecular and cellular pathogenesis, bacterial genomics and antibacterial research.
Table of Contents
1. Lessons and Challenges Arising From the "First Wave" of Chlamydia Genome Sequencing 2. Environmental Chlamydia Genomics 3. Chlamydia Proteomics 4. The Chlamydial Host- Pathogen Interaction: DNA Microarray Analysis 5. [Obligate Intracellular Parasitism]2: the Chlamydiaphages 6. Regulation of Gene Expression 7. In Silico Identification of Chlamydial Promoters and their Role in Regulation of Development 8. Tryptophan Metabolism in Chlamydiae 9. Iron and Micronutrients 10. The Polymorphic Membrane Protein Gene Family of the Chlamydiaceae 11. The Chlamydia Type III Secretion System: Structure and Implications for Pathogenesis 12. Proteins in the Chlamydial Inclusion Membrane 13. Chlamydial Exploitation of Host Signaling, Cytoskeletal, and Membrane Trafficking Pathways 14. A Pathogen with Two Personalities: Death and Survival during Infection with Chlamydia 15. Polarized Epithelial Cell Culture for Chlamydia trachomatis 16. Innate Immunity 17. The Role of the CD4 T Cell in the Host Response to Chlamydia 18. CD8+ T cell Recognition of Cells Infected with Chlamydia 19. T Lymphocyte Trafficking to the Female Reproductive Mucosae 20. Alternative Mechanisms of Pathogenesis 21. Pathogenesis of Chlamydia-Associated Arthritis 22. Interactions of Chlamydia with the Host Cells that Mediate Attachment and Uptake 23. The Impact of Chlamydia Basic Research on Disease Control